Isithembiso esinokuthenjwa kwi-Thyroid Treatment
Omnye othembisa ukufumana olutsha kwisifundo se-thyroid ukuqonda ubuhlobo phakathi kohlobo oludumileyo lwesifo sikashukela se- metformin (igama lophawu lwegama elibizwa ngeGlucophage) kunye ne-thyroid.
I-Metformin isetyenziselwa ukuphatha uhlobo lwesifo sikashukela se-2 kunye nokuxhathisa kwe-insulin. Kukho unxibelelwano oqondwa kakuhle phakathi kwe- insulin yokumelana -engaphezulu kunezinga eliqhelekileyo le-insulin, kunye namazinga aphezulu egazi e-glucose ebonisa ukuba i-insulin ayikwazi ukusebenza ekuncitshiseni ishukela legazi-kwaye kungekhona nje kuphela i-thyroid gland (goiter), kodwa ukuxhaphaka okuphezulu kwee -nodules ze-thyroid kunye nomhlaza we-thyroid.
Kuyathakazelisa ukuba uphando olutsha olushicilelwe kwi- Journal of Endocrinology lufumene ukuba izigulane eziphathwe nge-metformin zinomlinganiselo omncinci we-thyroid kunye nezantsi kwe-TSH, kodwa zanciphisa ingozi ye-goiter, i-nodules ye-thyroid kunye nomdlavuza we-thyroid.
Malunga neMetformin
I-Metformin, ethengiswa phantsi kwegama legama le-Glucophage, ithathwa njengesilwanyana sokuqala esetyenziselwa ukhathaza uhlobo lwesifo sikashukela , ngokukodwa kwizigulane ezigqithiseleyo . I-Metformin i- biguanide , ithetha ukuba iyanciphisa umkhiqizo wakho we-glucose, kwaye ikhulise ukuqonda komzimba wakho kwi-insulin. I-United States iqalile ukusebenzisa i-metformin ngo-1995, kwaye i-metformin ngoku iyisistim somlomo esisetyenziswe kakhulu kwi-type 2 yeswekile kwihlabathi jikelele. E-United States, iindleko eziqhelekileyo zonyango lwe-metformin zivela kwi-$ 5 ukuya kwi-25 yezigidi ngenyanga.
I-Metformin ne-Your Thyroid
Ucwaningo olukhulu lubhaliweyo kwi- Journal of Endocrinology lubhekiselele ubudlelwane phakathi kwe-metformin kunye nomsebenzi we-thyroid kwaye shwa nkathele imiphumo ebalulekileyo ye-metformin echaphazela unyango lwe-thyroid esikhathini esizayo.
Ngokukodwa, isifundo sichazwe kwiziphumo eziphambili zeziphumo:
- I-Metformin ne-Cancer Cancer: Iziphumo eziphando zophando zibonisa ukuba i-metformin iyancipha ukukhula kweekhensi ze-thyroid, kwaye inezinto ezibizwa ngokuba ngumsebenzi onqabileyo. I-Metformin yanciphisa kakhulu amandla okwenza i-insulin ukukhuthaza ukukhula kweefelithi ze-thyroid ezahlukeneyo, kunye neeseli zomhlaza we-thyroid, kuquka ne-anti-resistant-resistant anti -cancer cell cells. I-Metformin inqanda ukukhula kwaye ikhusela i-metastase kwi- medullary umdlavuza we-thyroid . I-metformin ibonakala iphazamisa iindlela eziphambili zokubonisa ukukhuthaza ukukhula okunjalo.
- I-Metformin ne-Thyroid Nodules: I- Metformin nayo ine-anti-proliferative activity against nodules ye-thyroid, iyancipha ukukhula kwayo okanye iyanciphisa ubukhulu bayo. Uphononongo lubhekisele kuphando olufumene ukuba kwizigulane ezinama-nodules amancinci angama-thyroid kunye nokuxhathisa kwe-insulin, unyango kunye ne-metformin kubangele ukunciphisa ubungakanani bee-nodules, kunye nokuhla kwezinga le-TSH. Olunye uphando olutshanje lwabasetyhini abanexinzelelo lwe-insulin kunye neengqungquthela ze-thyroid zifumene ukuba kuncitshiswe kakhulu ukukhulula kwindwangu yamagulane kwizigulane eziphathwe nge-metformin kunye ne-levothyroxine, ngokubhekiselele kwisilwanyana esithathwe sisodwa.
- I-Metformin kunye ne- TSH Ukunciphisa i-Thyroid Cancer Izigulane: I- Metformin unyango yayisoloko ihambelana namazinga e-TSH eyancipha, ebonisa ukuba inokuthatha indima kwimigqaliselo yangoku yemdlavuza we-thyroid ejoliswe ekunciphiseni amazinga eTSH ukukhusela umdlavuza we-thyroid. I-metformin ingaba luncedo kakhulu, kuba ibonakala ikhupha amanqanaba eTSH, ngaphandle kokubangela i-hyperthyroidism.
- I-Metformin neemeko ze-Thyroid ngohlobo lwe-2 lwe-Diabetics: Kukho ukukhawuleza kwe-diagnostic hypothyroidism kwi-type 2 ye-diabetics kwi-metformin. I-Metformin inxulumene namazinga ancitshisiweyo we-thyroid evuselela i-hormone (TSH) kwizigulana zesifo sikashukela. Kuhlobo lwesibini izigulane zesifo sikashukela esinesifo somhlaza we-thyroid, unyango kunye ne-metformin ludityaniswe nokukhululwa okuphezulu kunye nokusinda kwezilwanyana zesifo sikashukela esinesifo somhlaza we-thyroid, kunye neziphumo ezilungileyo kwizigulane zesifo sikashukela ezahlukileyo nomhlaza we-thyroid owaye wahluthwa kwi-lymph nodes. Abaphandi bathi i-metformin iphakamisa imiphumo ye-hormone ye-thyroid kwi-pituitary gland.
Iingqwalasela eziphambili
Ucwaningo luye lwabonisa ukuba i-levothyroxine yokutshatyalaliswa ayitshintshi ngokuthatha i-metformin, ngoko kuphephile ukuthatha izidakamizwa ezimbini ngokufanayo.
Noko ke, umngeni, kukuba, i-metformin inganciphisa i-TSH ngaphandle kokuchaphazela amazinga e-T4 okanye i-T3, ingabonakali imeko ye-thyroid ye-2 ye-diabetics ene-hypothyroidism ezithatha zombini i-metformin ne-levothyroxine. Kungaphinde kuphazamise ukuxhaswa kohlobo lwe-2 lwesifo se-diabetics esinesifo somdlavuza we-thyroid kwaye asifunanga kuphela amazinga e-TSH ashukumisayo, kodwa amanqanaba ajikelezayo aphezulu kwi-hormones ye-T4 kunye ne-T3 ukukhusela ukuphindaphinda komhlaza.
Ngokutsho kwabaphandi:
Iqondo leTSH elixinezelekileyo linikezela ngokuqinisekileyo lobuxoki okanye kunokususa ukuqaliswa kweyeza, okanye i-endocrinologists inokunciphisa i-levothyroxine] isilinganiselo kunye nezinga eliphantsi leTSH. Iiklinikhi kufuneka ziqwalasele umphumo we-metformin xa zichaza umsebenzi we-thyroid ukuphepha naluphi na unyango olufanelekileyo okanye utshintsho lwe-levothyroxine].
Ukunciphisa i-dosage kungabangela ukuba iimpawu ze-hypothyroidism zibuyele ngenxa yokuba, nangona i-TSH ephantsi, akukho nto ikwazi ukujikeleza i-hormone ye-thyroid ukuze ukhulule iimpawu ze-hypothyroid.
Ukongeza, emva kokuhlinzwa ukuba ususe igulane ukunyanga umdlavuza we-thyroid, izigulane ezininzi zifakwa kwiphilisi yokunyanzelisa, ukugcina izinga le-TSH liphantsi kakhulu kwaye izinga le-hormone ye-thyroid liphezulu ukukhusela umdlavuza we-thyroid. Uhlobo lwe-2 lwe-diabetics onomdlavuza we-thyroid, kwaye unayo i-thyroidectomy ukususa i-gland, i-TSH ephantsi ngokuchaneka ngenxa ye-antiformin therapy ingabonisa ukuba kufuneka umlinganiselo we-levothyroxine. Le nciphiso kwi dose, nangona kunjalo, ayikwazi ukufezekiswa kwinqanaba leselula.
ILizwi
Ezi ziphumo ezintsha ezithandekayo zibonisa ukuba kunokubakho inani elinokusetyenziswa kwe-metformin kumaqela amaninzi:
- Uhlobo lwe-2 lwesifo sikashukela ngesifo se-thyroid
- Uhlobo lwe-2 lwe-diabetics olungenayo isifo se-thyroid
- Abantu abane-hypothyroidism abane-insulin yokuxhatshazwa, isifo se-metabolic syndrome, kunye / okanye ukukhuluphala
- Iintsholongwane zomdlavuza we-Thyroid kwi-TSH-treatment suppression
Ngeli xesha, ke, iingcali zincoma ezinye izifundo zekliniki ukuba zihlole kangcono ukusetyenziswa kwe-metformin njengenxalenye yesifo se-thyroid kunye nokuseka iinkqubo zonyango kunye nezikhokelo.
Ukuba u-hypothyroid, kwaye unokuxhatshazwa kwe-insulin, kodwa awusayi kuthatha i-metformin, kungenokuba luncedo ukuthetha kunye nodokotela wakho ngokuphathelele ukuzongeza kwiprogram yakho yokonyango. I-Metformin ithathwa njengeziko elikhuselekileyo elinemiphumo emibini, kwaye imiselwe ukuba isifo se-metabolic / pre-diabetes / ukukhushulwa kwe-insulin, kwaye inokumisa ukunyuka kwe-diabetes. Ezi ziphumo zintsholongwane zibonisa ukuba unokuba nefuthe lokukhusela kwi-thyroid yakho.
> Imithombo:
> Distiller LA, et al. "Uhlobo lwe-2 lwesifo sikashukela kunye ne-hypothyroidism: impembelelo enokwenzeka ye-metformin." I-Diabet Med 31 172-175. 2012.
> Xianghui M et al. "Ukuphonononga: iMetformin kunye nesifo se-thyroid." Journal of Endocrinology. Ukupapashwa kwe-intanethi, ngomhla we-14 kuFebruwari 2017. I-Abstract / Full PDF