Iimeko ezahlukeneyo zesikhumba ezihlukeneyo, eziquka i- eczema , i-urticaria kunye ne-angioedema, kunye ne-erythema multiform, inokudakalisa ngexesha lexesha lokuqala. Xa le miqathango ibenzakala ngakumbi kwiintsuku ezintathu ukuya kwi-10 ngaphambi kokuqala kweemens, le ntokazi inokuba neprogesterone dermatitis (APD) ngokuzenzekelayo. I-APD nayo inako ukuqhubela phambili kwi- anaphylaxis .
Enye ifom ye-anaphylaxis ehambelana nomjikelezo wokuya esikhathini, i-anaphylaxis ekhulayo. Ezi zombini zikholelwa ukuba ziyimimandla engavumelekanga.
I-Progesterone Dermatitis
I-progesterone dermatitis (APD) ye-autoimmune eyenziwa ngokuzenzekelayo iyenzeka ngenxa yesiphumo esiphumelelayo kwiprogesterone yowesifazane. Iimpawu zenzeka rhoqo ukusuka kwiintsuku ezintathu ukuya kwi-10 ngaphambi kokuqala kweemens kwaye ziqale ukulungisa kwisithuba esinye ukuya kweentsuku ezimbini emva kokuqala kokuya esikhathini. I-APD ingaba neempawu ezahlukahlukeneyo, nangona uninzi, ukuba awunabo bonke, zibandakanya iziqholo zesikhumba. Ezi ziquka i-eczema, imihlathi, ukuqhuma kweziyobisi, i-erythema multiform, i-angioedema, kunye ne-anaphylaxis. Kungenzeka ukuba okokuqala kungabonakali kumfazi ochaphazelekayo ukuba iimpawu zakhe zibuhlungu ngexesha lokuqala, kwaye ngokuqhelekileyo kuthatha ugqirha ukuba abuze umbuzo wokuba utyhafile iimpawu ezinxulumene nomjikelezo wesini ngaphambi kokuba umzekelo ubonakale kulo mfazi.
I-APD inokubangela ekuqaleni ngowesifazane ophethe iipilisi zokulawula ukuzala okanye enye isongezelelo se-hormone equkethe i-progesterone ekhokelela ekuboniseni i-hormone. Ukukhulelwa kungakhokelela ekuqinisekiseni i-progesterone, kwaye ukukhulelwa kunokuba nemiphumo ebalulekileyo kwi-immune system kwaye inokuchaphazela ngokugqithisileyo iimeko ezahlukeneyo zokuzikhusela.
Abanye abafazi bangakha i-APD ngenxa ye-reactivity ye- corticosteroids , eneempawu ezifanayo ze-molecular to hormones. Nangona ukuphendulwa komzimba kwezinye i-hormone, ezinjenge-estrogen, kuya kwenzeka, ezi ziphantsi kakhulu kunokuba ziphendule kwi-progesterone.
Ukuxilongwa kwe-APD kudinga ukubonakaliswa kwe-anti-antibodies ye-IgE ngokumelene neprogesterone, eyenziwa ngokuvavanywa kwesikhumba . Ukuvavanywa kwesikhumba kunye neprogesterone kunokwenziwa ngabaninzi bezilwanyana zonke, ezinokulandelwa ngumngeni weziyobisi ngokusebenzisa injola yeprogesterone ngokuqwalaselwa okufutshane kweempawu. Le nkqubo kufuneka iqhutywe kuphela ngugqirha onobuchule ekuxilongweni nasekunyangeni kwe-allergies kunye ne-anaphylaxis, enikezwa ukuba kungenzeka ukuba inokuthi ingozi yenzeke yingozi ngenxa yolu vavanyo.
Unyango lwe-APD lunokuphumelela ngokusetyenziswa kwama- antihistamines kunye ne-corticosteroids yomlomo okanye ye-injection, nangona la mayeza aya kuba luncedo ekunyangeni iimpawu kunokulungisa loo ngxaki. Iipilisi ezithintela i-ovulation, efana ne-leuprolide, inqanda ukunyuka kweprogesterone ngexesha lokuhamba kwimizi kwaye ziyeza unyango lwe-APD. Ngokuqhelekileyo, ukukhishwa kwamathambo amaqanda kunye nesisu kufuneka kwiimeko ezinzima ze-APD xa unyango alukwazi ukulawula iimpawu.
Anaphylaxis
Enye i-anaphylaxis yenyama enye imeko ehambelana nomjikelezo wesini. Abasetyhini abanalo meko bafumana iimpawu ze-anaphylaxis ngokukhawuleza ukuqala kokuya esikhathini kwaye iimpawu ziyaqhubeka kude kube yilapho ukuphuma kwemitha kuphelile. Ngokungafani ne-APD, nangona kunjalo, i-anaphylaxis ekhulayo ayiyiyo imeko yokugula kodwa kunokuba ibangelwe yi- prostaglandins ekhishwe kwimbumba yesisu (endometrium), enokuthi ingene kwigazi. Ukuxilongwa ngokuqhelekileyo kwenziwa rhoqo kwiiklinikhi, njengoko ukuhlolwa kokungabikho komzimba ku-progesterone (kunye namanye ama-hormone) akubi. Unyango lwe-anaphylaxis ephucukileyo uye waphumelela ngokusetyenziswa kweyeza-non-steroidal anti-inflammatory (NSAIDs ) , ezifana ne-Indocin (indomethacin).
Ukutshatyalaliswa kokutshitshiswa kwama-ovari kunye nesibindi kuyadingeka kwiimeko ezinzima zokubulala i-anaphylaxis xa unyango alukwazi ukulawula iimpawu.
> Imithombo:
> I-Progesterone Dermatitis. I-Genetic NIH kunye neZiko loLwazi loLuntu. https://rarediseases.info.nih.gov/diseases/9139/autoimmune-progesterone-dermatitis.
> Bauer CS, Kampitak T, Messieh ML, Kelly KJ, Vadas P. Heterogeneity kwintetho kunye nokunyangwa kwe-anaphylaxis yokugaya. Ama-Annal of Allergy, i-Asthma & Immunology . 2013; 111 (2): 107-111. i-doi: 10.1016 / j.anai.2013.06.001.
> Nguyen T, Ahmed AR. I-progesterone dermatitis ngokuzenzekelayo: Ukuhlaziya kunye nokuqonda. I ziPhulo zeMoto . 2016; 15 (2): 191-197. i-doi: 10.1016 / j.autrev.2015.11.003.