Iziphumo eziPhakathi, izilumkiso, kunye nolunye ulwazi olubalulekileyo
I-Simponi (golimumab) luhlobo lweziyobisi ezibizwa ngokuba yi-TNF-alpha (i- tumor necrosis factor alpha ). Kuye kwafumanisa ukuba i-TNF idlala indima ekuphuhliseni isifo sesisu se- inflammatory (IBD). I-TNF ifumaneka kwimali ephezulu kwiikholoni zabantu abane-ulcerative colitis nesifo sikaCrohn kunabantu abangenawo nawuphi na uhlobo lwe-IBD.
I-Simponi, njengamanye amayeza omzimba omzimba asetyenziswa ukuphatha i-IBD, ibophezela kwi-TNF-alpha kwaye iyenqanda ukuba isetyenziswe ngumzimba. Esi sidakamizwa senziwa nguJanssen Biotech.
Abaphandi bacinga ukuba i-TNF-alpha inendima kwi-IBD kunye nenkqubo yesisu. I-IBD yimeko yokuvuvukala, kwaye i-TNF-alpha ngumthunywa weekhemikhali obizwa ngokuba yi- cytokine . Ii-Cytokines zithethi nje kuphela "imiyalezo" phakathi kweeseli zomzimba, kodwa zidlala indima ekukhuthazeni inkqubo yokuvuvukala.
I-Simponi ithathwa njani?
I-Simponi inikezwa njengenjenge phantsi kwesikhumba. Emva kokuqeqeshwa ngunyango lwezezempilo, izigulana zikwazi ukuzinika i-Simponi injection ekhaya. Iilenki ziya kuza kunye nemiyalelo ecacileyo ekusebenziseni kwabo, kwaye ugqirha uya kumnika nayiphi na enye imiyalelo ekhethekileyo ukuba izigulane zifanele zilandele. Ukuqalisa i-Simponi, kukho ii-injection ezi-2 zokuqala. Okulandelayo, i-injection ye-1 inikwe iiveki ezimbini emva koko.
Kwaye ke, ukuze ulondolozwe, i-Simponi injection inikezelwa rhoqo kwiiveki ezi-4.
Ukusetyenziswa
I-Simponi ivunyiwe ukuphatha unyango olulinganisiweyo lwesifo esilumkileyo kwiimeko ezingaphenduliyo kumachiza angaphezulu (ayisebenzisi njengowokuqala unyango kwimeko). I-Simponi iphinde ivunyiwe ukunyanga i- rheumatoid arthritis , i-psoriatic arthritis, kunye ne-spondylitis e-ankylosing.
I-Simponi isebenza ukukhusela ukuvuvukala ngokubambisana kwi-TNF-alpha. Xa i-TNF-alpha ingasabikho ukudala ukuvuvukala, i-IBD inokungena ixesha lokuxolelwa (xa umsebenzi wesifo kunye neempawu zihamba).
Ngubani Akufanele Athathe Ulula?
Tshela ugqirha wakho ukuba uphathwa ngentsholongwane, ukuba uyiphatha ye-virus ye-hepatitis B, sele ufumene isitofu esipheleleyo sokuphila, okanye uke wabuyela kwisimo se-Simponi.
Imiphumela
Iziphumo eziqhelekileyo ezichaphazelekayo ze-Simponi ziquka ukusuleleka kwintsholongwane yokuphefumula, ukusabela kwendawo ye-injection (njengobomvu okanye ukuvuvukala), kunye neentsholongwane zentsholongwane ezifana nomkhuhlane kunye nezilonda ezibandayo . Tshela ugqirha wakho ukuba nayiphi na imiphumo emibi ingxaki okanye ungahambi. Ezi mpawu zimele zixelelwe ngudokotela wakho ngokukhawuleza.
Ezinye izixwayiso Kwiempembelelo ezimbi
I-Simponi kunye namanye amayeza e-TNF-blocker adibene neentlobo ezithile zentsholongwane, kuquka nesifo sofuba. Naluphina ukutyhila kumntu onesifo sofuba kufuneka kuxelelwe kugqirha. Izigulane ezithatha unyango kunye ne-Simponi kufuneka zihlolwe isifo sofuba (kubandakanywa nesimo esiqhekezayo sesifo), kwaye sithathwe unyango xa kuyimfuneko. Ngethuba uthabatha eli gciwane, izigulane kufuneka zijongwe kwakhona iimpawu okanye iimpawu zesifo sofuba, njengale:
- Iintlungu zesifuba
- Isiqhamo
- Fever
- Ukuphelelwa kwesidlo
- Ukukhupha ebusuku
- Ukuhla ukusinda
Ezinye iintlobo zokusuleleka nazo zinokwenzeka, njengoko le nyilisi iyanciphisa ukunyanga komzimba kumayeza atshabayo. Izigulane eziye zahamba kwindawo eneziganeko eziphezulu zezifo ezifayilini okanye ezinezitsholongwane zangoku kufuneka zixelele le miqathango ugqirha echaza i-Simponi.
I-block block TNF zidibene nokuphuhliswa kweentlobo ezithile zeekresela. I-Lymphoma ibiwe kubantu abathatha i-TNF blockers. Ngokukodwa, umngcipheko wokuphuhlisa i-hepatosplenic T-cell lymphoma yanda, ingakumbi kubafana abaselula.
I-Simponi idibene nokuphuhliswa komhlaza wesikhumba . Abantu abathatha i-Simponi kufuneka baqaphele nayiphi na utshintsho kwesikhumba sabo, njengokukhula okutsha okanye ii-moles eziguqula umbala okanye ukuma.
Abantu abaphethe i- virus ye- hepatitis B basemngciphekweni wokusuyiselwa kwintsholongwane xa bethatha unyango lwe-TNF. Izigulane ezithatha i-Simponi zifanele zihlolwe i-hepatitis B kwaye zimele ziqaphele iimpawu kunye neempawu ze-hepatitis B ezifana ne:
- IChills
- Ukunyakaza kwamathumbu ombala
- Umchamo omnyama
- Ukukhathala okukhulu
- Iifutha
- Ukungabi nesidlo
- Iintsimbi zomzimba
- Utywala
- Isisu esingathandekiyo
- Ukuvutha
- Isikhumba esifutshane okanye amehlo
Inani eliphantsi legazi liye lagcinwa kwezinye izigulane ezithatha izidakamizwa ezichasene ne-TNF. Oku kuyinkxalabo ekhethekileyo kubantu abane-IBD, abasemngciphekweni wamanqanaba aphantsi eeseli ezibomvu zegazi. Ugqirha wakho uya kubeka iliso lakho igazi ngokukhawuleza ukujonga i- anemia .
Ezinye iingxaki ezinokuthi zenzeke ngelixa zingaphantsi kwe-TNF unyango lubandakanya ukungaphumeleli kwintliziyo, i-multiple sclerosis, i-Guillain-Barré syndrome, isifo sesibindi, i-psoriasis kunye neempawu ezifana ne-lupus-like.
Ukutya kunye nokuHlangana kweziMilo
I-Simponi idla ngokubanjiswa kunye nezinye iziyobisi ezisetyenziswa ukuphatha i-IBD njenge-corticosteroids. Amayeza anokusebenzisana no-Simponi afaka:
- Kineret (anakinra)
- Orencia (abatacept)
- Rituxan (rituximab)
- Phambi kweigciwane
Akukho ukusebenzisana kokutya okuyaziwayo.
Ukhuseleko ngexesha lokukhulelwa
I-FDA ifake i-Simponi njengesiqhelo seB B. Impembelelo yokuba i-Simponi inomntwana ongakazalwa ingazange ifundwe ngokubanzi. I-Simponi kufuneka isetyenziswe kuphela ngexesha lokukhulelwa xa kuyimfuneko. Yazisa ukuba ugqirha ukuba uyakhulelwa ngelixa uthabatha i-Simponi. Ayaziwa ukuba i-Simponi idlula ubisi lwebele, nangona ezinye izinto ezifanayo ziboniswe ukuba zidlule ubisi lwebele. Ubungakanani bemiphumo emibi ebusweni kwintsana kufuneka lulinganiswe ngokusetyenziswa kweyeza kumama. Enye inketho ukuyeka ukuncelisa ngaphambi kokulawula i-Simponi.
Imithombo:
Janssen Biotech, Inc. "Inkqubo Yonyango Elula." Meyi 2013.
Janssen Biotech, Inc. "I-website ye-Simponi." Meyi 2013.
Olsen T, Goll R, Cui G, et al. "Amanqanaba omzimba we-tumor necrosis ye-alpha correlates kunye nesigaba sokuvuvukala kwi-colitis ye-ulcerative colitis." Scand J Gastroenterol . 2007 Nov; 42: 1312-1320.
URoberts-Thomson IC, i-Fon J, u-Uylaki W, i-Cummins AG, uBarry S. "Iiselithi, ii-cytokines kunye nezifo zesibindi sokuvuvukala. Iingcali zoLwazi uGastroenterol Hepatol . NgoDisemba ka-2011; 5: 703-716. i-doi: 10.1586 / egh.11.74.