Ubulumko obuqhelekileyo buhlala busithi ukuvuvukala kungabonakali kwizigulane ezineengxaki zesifo seengqondo (IBS). Ewe, amaxesha anokuba aguqula.
Ukucima umcando uphando sele uqale ukufumana ubungqina bokuvuvuka kwezinga elingaphantsi kwimizimba yesigxina sezilwanyana kwezinye izigulane ze-IBS. Kucatshangelwa kakhulu okokuqala, ezi ziphumo zingaphaya indlela eya kwiindlela ezintsha zokuphucula unyango.
Ngenxa yoko, kukho izinto ezimbalwa ofuna ukuzazi malunga nendima enokuthi ukuvuvukala kungadlala ekuphuhliseni nasekugcinweni kwe-IBS.
Ukuchaza izinto ezibalulekileyo ezibini
Iiseli ezincinci. Amaseli omzimba afumaneka kwiisishu kuwo wonke umzimba. Bakholelwa ukuba badlale indima ebalulekileyo ekukhuseleni umzimba kumagciwane-ngaphandle kwee-agents, ezinjengeentsholongwane okanye iintsholongwane, ezibeka ingozi kwimpilo yakho. Kucatshangelwa ukuba iisitrasi ezincinane ziyakwenza impendulo ngokukhawuleza ekuvukeleni kwi-pathogen. Ngaloo nto, akumangalisi ukuba iifestile ezibonakalayo zibandakanyeke kakhulu kwizinto esiyazi ngokuqhelekileyo njengezifo.
IiCytokines. I-Cytokines iiprotheni ezikhutshwa ngamathambo esitye kunye nezinye iiseli ezinxulumene nokuphendula komzimba. Kucatshangelwa ukuba emva kokuphendula okukhawulezayo okuvuthayo okubangelwa ngamaseli esisigxina, inkqubo eqhubekayo yokuvuvukala iyenzeka ngenxa yokukhutshwa kweentlobo ezithile ze-cytokines. I-Cytokines ingaba yi-pro-inflammatory okanye anti-inflammatory.
Ingxaki ekhoyo
Ukuze ubone ngeso lengqondo impendulo yokuvuvukala, cinga ukuba umzimba wakho unesifo sengxaki yesifo sesisu esiswini esibi ( gastroenteritis ). Amaseli omkhulu asabela ngokukhawuleza, alandelwe yi-cytokines, ukulwa nokusuleleka kuye. Ukukhululwa kwezi zinto kubangela intlungu yesisu , ukuxinwa, kunye nehudo .
Kwiimeko ezininzi, impendulo yokuvuvukala yesikhashana. Xa umzimba uphawula ukuba umtshayeli unqatshiwe, inkqubo yokuvuvukala ivala.
Olunye uphando lubonakala lubonisa ukuba, kwisigxina esinezigulane ze-IBS, le nkqubo yokuvuvukala iyaqhubeka emva kokuba usulele ukhuseleko. Izinto azifaneki zilula nge-IBS. Kwakhona kunokwenzeka ukuba kukho abanye abantu abafumana ukutshabalala okungapheliyo ngaphandle kokufumana isigwebo esicacileyo se-gastroenteritis.
Kukho nawuphi na, ukuqhutyelwa kokuqhubeka kweeseli zesigxina, nokuba kwimeko enobumnene, kunokufaka isandla ekusebenziseni i- motility ukungabikho komsebenzi obonakalisa i-IBS, ngokukodwa ngokubhekiselele kwiziganeko zokurhudo. Ukongezelela, iisisiti zesitrasi zingasifumana kakhulu kufuphi neeseli zesigulane emathunjini. Oku kunokufaka isandla kwiintlungu eziqhubekayo kunye ne- visceral hypersensitivity efana ne-IBS.
Izinto ezinobungozi
Akucaci ukuba kutheni le nto iqhubekile yokunyusa inokuchaphazela abanye abantu kungekhona abanye. Uphando olungakumbi lufunekayo ukuphanda oku kulandelayo:
- I-Genetic predisposition
- Iimeko ezichanekileyo zokugaya amabhaktheriya
- Ukutya kokutya
- Ukuxhatshazwa ngokuqhelekileyo
Ngaphantsi
Uphando malunga nendima yokuvuvukala okuqhubekayo ekuphuhlisweni nasekugcinweni kwe-IBS kusekuqaleni kwexesha.
Yintoni eyaziwayo kukuba, kwinani elithile elincinane lezilwanyana ze-IBS, ukwanda kweeseli ezivuthayo kufunyenwe kwicala lomathumbu omkhulu kunye nengxenye ye-leum yesisu esincinci. Olu kuvutha alukwazi kubonwa nge-microscope njengenxalenye yenkqubo eqhelekileyo ye-biopsy kodwa kufuna iimviwo ezingakumbi. Izigulane ezinezicubu eziqukethe izinto ezivuthayo zivame ukuba zihlupheke kwi-IBS (IBS-PI) okanye i- diarrhea-ebalulekileyo kwi-IBS (IBS-D).
Kucacile ukuba uphando olongezelelweyo lufuneka luqhutywe ukuze kuphuhliswe umfanekiso ogqithisileyo wendima yokuvuvukala kwi-IBS.
Ithemba kukuba ukuqonda okuphuculweyo kuya kukhokelela ekuphuhlisweni kwonyango olutsha kunye nokuzisa intlungu ekuhluphekeni.
> Imithombo:
> Chira A, Chira RI, uDumitrascu DL. Ukuvuvukala njengeThagethi yeTragetutic Target kwi-IBS. Ku: I-Irritable Bowel Syndrome - IiNkcazo zeNzululwazi zoPhando kunye neZonyango. InTech, DOI; 2016; 10.5772 / 66193.
> Liebregts T, uBirgit A, uBredack C, et al. Ukuvuselela Umzimba Kwizigulane Nge-Irritable Bowel Syndrome. Gastroenterology. 2007; 132: 913-920. i-doi: http: //dx.doi.org/10.1053/j.gastro.2007.01.046
> Norton W, Drossman D. I-Summary Summary Report. Imiba yezeMpilo yeNtloko. 2007; 16: 4-7.