Iiseli ezincinci iiseli ezitholakala kwiisisombululo ezixhamlayo kuwo wonke umzimba wethu njengenxalenye yesimiso sethu somzimba. Iiseli ezincinci zivelele kakhulu kwiisisu zomzimba wethu ezidibanisa nehlabathi lethu langaphandle, njengalezo ezifumaneka kwesikhumba nasemaphepheni ethu okuphefumula kunye nokutya . Iiseli ezininzi zingaphinda zifunyanwe kwizitho kunye nezicubu zeenkqubo zethu ezijikelezayo kunye neentsholongwane.
Iiseli ezincinci zidlala indima ebalulekileyo ekukhuseleni impilo yethu ngokubonelela umgca wokuzikhusela kumagciwane .
Imisebenzi yeMast Cell
Ekuphenduleni kokuchazwa kwintsholongwane ebonakalayo, amangqamuzana amancinci amisa ukuphendula okukhawulezayo kubahlaseli bangaphandle, njengegciwane, iintsholongwane kunye nama-parasites. Amaseli amancinci anako ukubulala ngokuthe ngqo ezi ziphilayo okanye ukukhuthaza ukuveliswa nokukhutshwa kwezinto eziza kubhubhisa i-pathogen.
Iiseli ezincinci zidlala indima ebalulekileyo ekusebenziseni iimpendulo zokungapheleli. Xa umntu enesifo sengqondo, amangqamuzana amantshontsho ayaphendula kwizinto ezinobungozi ezingathi ziyingozi.
Ukongeza kwimiqathango yabo yokukhusela kunye neenkqubo zokuzivikela kumzimba, iintsholongwane zamatye zibandakanyeka:
- I-Homeostasis yemithambo yegazi kunye nokusebenza kwe-bronchial
- Ukuphulukiswa kokulimala
- Ukwenziwa kwemithambo yegazi entsha
- Ukulawula ukusebenza kweeseli kuwo wonke umzimba
- Umgaqo wokukhula kwamathambo
IMast Cell Response
Ngokuphendula kwisongelo esicatshulwayo, amangqamuzana amancinci akhupha ukukhutshwa kwezidibanisi zezixhobo zamagciwane, ezifana ne-histamine kunye ne-serotonin, kunye ne-enzymes ezifana ne-cytokines kunye ne-proteases.
Ezi zinto ziphumela kwiimpendulo ezikhawulezayo kunye nexesha elide lokuvuvukala. Makhe sijonge ezinye zeempendulo zeesitalato eziqhelekileyo.
Impendulo yesigxina
Xa sidla into ebonakala ukuba yingozi, iisaliti zesisitya ziya kubangela impendulo enemiphumo elandelayo:
- Ukwandisa ukukhutshwa kwamanzi
- Ukwandisa ukusikwa kwemisipha ngaphakathi kwenkqubo yokutya (kunokubangela ukuhlanza okanye uhudo)
- Hambisa umba wefecal ngokukhawuleza kwi-colon
Ezi zenzo zinengqiqo, akunjalo? Umzimba uzama ukukrazula oko kukubona kukulimaza ngokukhawuleza njengoko kunako.
Iiseli ezisisigxina zidlala indima ebalulekileyo ekukhuthazeni ukulinganisela okusemgangathweni kweebhaktheriya ezenza i- flora yethu . Njengoko iifestile zesithambiso zifunyenwe kuwo wonke umgca wegulane lethu, zidlala indima ekubhubiseni nasekukhuseleni imizimba yethu kunoma yiyiphi ibhaktheriya ye-pathogenic.
Impendulo yokuphefumula
Amaseli omzimba atholakala kuwo onke amacandelo ethu okuphefumula. Ukuphendula kwisifo se-antigen, ngokuqhelekileyo esisetyenzisiweyo, iiseli zesigxina ziza kubangela impendulo yokuzivikela omzimba equka:
- Ukunyanzeliswa kweendlela zethu zomoya
- Ukudibanisa
- Ukuhlahlela
- Ukwandiswa kwemveliso ye-mucus
Njengoko unokubona kwimiphumo engentla, akumangalisi ukuba iisiti zeentsimbi zibandakanyeka kakhulu kwiimpawu zesifo se -asthma .
Impendulo yesikhumba
Mhlawumbi uqhelana nombono wokuthi abanye abantu bafumana imingxuma okanye ukukhawuleza ngokuphendula ukutya kokutya okuthile. Oku kwenzeka ngenxa yokuba ama-antigens ekudleni angena egazini ngephepha le-GI. Njengoko bejikeleza emzimbeni badibanisa neeseli zesisiti ezifunyenwe kwiiscuzu zesikhumba.
Impendulo evuthayo yale mast cells ingabangela ukuvuvukala, imisundu, i-rashes kunye nengxaki engapheliyo ye- atermic dermatitis (eczema).
Izilwanyana ezincinci kunye neentsholongwane zokugula
Ngenxa yokuba iisitaliti zesitrasi zibeka umzila wamathumbu, kwaye zanikezela ngemiphumo yazo ngokumalunga nokuphendula komzimba, izicatshulwa zesistim ziye zathinteka ekusebenzeni indima kwezi zifo zibini zesisu:
Imiphumo yesigxina seesistim sinokubangela iziphumo ezilandelayo:
- Ukuhamba ngokukhawuleza kwe-stool (kubangela ukuhanjiswa kwesisu)
- Ukwandiswa kwemfihlo yamanzi emathunjini amakhulu (kunye negalelo ekuhupheni)
Okuthakazelisayo kukuba, izenzo zeentsimbi zesisitya zingathonyelwa ngumlinganiselo woxinzelelo ophantsi. Kukho kubonakala kubonxibelelwano obubini phakathi kweeseli zesistim sakho senzwa kunye neeseli zamathambo. Ngaloo ndlela izenzo zeentsimbi zentsimbi zingadlala indima ephambili kwizinto zokuthi iimpawu ze-IBS zingadluliselwa kukukhathazeka kwangaphandle.
Ucwaningo luye lwabonisa ukuba kukho inani elinyukayo leeseli zamathambo kumabilini emathumbu abantu abane-IBS. Iinzululwazi azikwazi ngokubanzi malunga nokuba kutheni le nto kunjalo, kodwa yindawo enomdla yophando njengoko ikhokelela ekuphuculweni kwonyango olutsha olululo.
Imithombo:
U-Krystel-Whittemore, M. "I-Cell Mast: I-Cell Master esebenza ngokubanzi " Imimandla e-Immunology 2015 6: 620.
Philpott, H., Gibson, P. & Thien, F. "Isifo esilumkileyo samathumbu - Isifo esivuthayo esibandakanya iisitrasi zeengcambu" I- Asia Pacific I-allergies 2011 1: 36-42.
Ramsay, D., kunye. al. "Iinqununu ezininzi kwizifo zesisu" I- Gastroenterology & Hepatology 2010 6: 772-777.
I-Urb, M. & Sheppard, D. "Indima yeeNgcini zeMast in Defence against Pathogens" I- PLoS Pathogens 2012 8: e1002619.