Funda kabanzi malunga neentlobo zePaenibacillus ezinomthamo we-VT 400
Ehlotyeni ka-2016, kwintlanganiso yonyaka ye-American Society ye-Microbiology, izazinzulu zihlanganisene ukwabelana kwaye zixubushe iziphumo eziphathelele kwihlabathi leebhaktheriya nempilo yabantu.
Phakathi kwezinto ezifunyenweyo, iqela libikwe kwi-genome yonke, okanye i-gene epheleleyo, kwi-bacterium ebizwa ngokuba yi-Paenibacillus i-VT 400 (PVT400). Ezi bhaktheriya zazifunyenwe ngaphambili kwi-saliva yesigulane sabantwana abane- acute lymphoblastic leukemia (BONKE).
Ulwazi oluthe nkcukacha kule nkqubo nakwixesha elizayo luza kunceda oososayensi bafunde ukuba ngaba iibhaktheriya zinokuthatha inxaxheba kwizifo zabantu, ingakumbi kubantu abaneengxaki zegazi ezinokukhusela i-pneumonia okanye i-bloodstream infections.
I-Pneumonia kubantu abaneCarcer
I-pneumonia yimbangela ebangela ukufa kubantu abanezigulane ze-neutropenia, ngakumbi abo bane-leukemia. I-Neutropenia ibalo elincinci le-neutrophils kwi-neutrophils yegazi ngamaseli asegazini amhlophe abalulekile ekuncedeni umzimba ukulwa nesifo .
Izifo ezithintekayo zokuphefumula zixhaphake kakhulu kwizigulane zomhlaza, kunye neengxelo ezithile ezibonisa ukuba izigulane ezingama-13 ukuya kwe-31 zezigulane ze-leukemia zifumana i-chemotherapy kunye nama-80 ekhulwini we-hematopoietic stem cell transplant recepters ziza kuba namava enye kwimeko yesifo se-pneumonia.
I-pneumonia ye-Neutropenic inokuthi isongela ubomi. Kwiimeko ezinjalo, oogqirha baqala unyango lwe-antibiotic ngokukhawuleza, ngaphandle kokulinda iziphumo zebhoratri ukuqinisekisa kwaye bachaze uhlobo lokusuleleka kwe-bacterial-kuba kubaluleke kakhulu ukuqala unyango ngexesha elilodwa, ukunciphisa umngcipheko wokuba isigulane siphumelele kwisifo.
Enyanisweni, unyango olukhuselweyo lusetyenziswa kwezinye iimeko, ezichazwe ngezantsi.
Ukuqhubela phambili kwindlela yokulawula i-neutropenic pneumonia kudala ithemba lokufumana iziphumo ezingcono. Iinkampani ezininzi zonyango ziye zakhupha izikhokelo ezihlaziyiweyo zonyango lwe-antibiotics ye-pneumonia ye-neutropenic.
Kwaye kunokwenzeka ukuba amatsha amaninzi aphakamisa iimpendulo zomzimba kwiintsholongwane angaphakamisa umsebenzi wee-antibiotics.
Ukugxila kwii-Pathogens kwizigulane ezineNetropenia
Izikhokelo ezivela kwi-American Society of Clinical Oncology (ASCO) zincomela ukuba oogqirha bazama ukuthintela ukusuleleka kwiintsholongwane kunye ne-neutropenia enzulu kodwa akukho mkhuhlane. Ulwaphulo lwe-antibacterial and antitifungal lucetyiswa ukuba i-neutrophils ilindeleke ukuba ihlale ingaphantsi kwe-100 / μL iintsuku ezisixhenxe. Isikhokelo sichaza ukuba i-arhente ekhethiweyo yonyango lokukhusela isifo sokulwa ne-antibacterial is a fluoroquinolone yomlomo, ngelixa ukuba unyango lwe-antifungal lu-triazole yomlomo.
Izigulane ezine-neutropenia zithinteka kwiintlobo ezininzi zezilwanyana eziphilayo kunezihlobo zabo. Oku kunokuba luncedo oogqirha ukuba baqwalasele apho iibhaktheriya zivela khona ekuchazeni ukuba yiyiphi i-antibiotics ayimelana nayo, kwaye ngoko ke iziphi izicwangciso ezinokuthi zisebenze kakhulu.
I-Paenibacillus Species
Kuloo nto, izazinzulu ziye zafunda i-PVT400, ibhaktheriya entsha esecaleni kwesigulane se-leukemia, ilungu le-Paenibacillus-uhlobo lweentsholongwane ezinobumba obuthile. Iintlobo ezahlukileyo ngaphakathi kweli qela ziye zahlukana kumhlaba, amanzi, izityalo, ubisi kunye nezinye izingosi.
Nangona kunjalo, iintlobo zePaenibacillus zazingaziwa zibangelwa izifo zabantu. .. kude kube neengxelo zangoku zibonise ukubandakanyeka kweentlobo ezahlukeneyo zePaenibacillus kwizifo zabantu.
Emva kokuba i-PVT 400 yahluke kwi-saliva yesigulane sabantwana ngesifo se -lymphoblastic leukemia , izifundo zakuqala zabonisa ukufana kwezi zihlunu kunye neentlobo ze-amylolyticus, ezitholakala kwi-hindgut ye-flyy of fly; Nangona kunjalo, ukuza kuthi, kusenokwenzeka ukuba iP. amylolyticus ayifumanwanga kubantu, kwaye uphando olongezelelweyo lubonisa ukungafani phakathi kwe-bac 400 ye-bacterial strain efumanekayo kwisigulane somhlaza kunye nezinye i-P.
i-amylolyticus.
Ngoko ke, xa uphando bafunda yonke i-genome ye-VT 400, kwakukho iziphumo ezithandekayo. Kwakudala i-gene encoding mechanisms anti-chemotherapy drugs, njenge-tunicamycin kunye ne-bleomycin. Bafumene izifo zamapompo ezinobungozi obuxhatshazwa ngamagciwane, kunye neentlobo zokumelana nokuchasana namayeza, kuquka i-vancomycin, i-fosmidomycin, i-tetracycline kunye ne-penicillin-like drugs, okanye i-beta-lactam.
Ababhali be-geneome-study baqaphele ukuba ukulandelelana kwe-genome epheleleyo yePaenibacillus sp. I-VT 400 iya kunceda ukufumana indima yeentlobo zePaenibacillus kwizifo zabantu kwaye zinike ulwazi malunga nokwakhiwa kweebhaktheriya eziqhelekileyo ezihlala kwizigulana ezinegazi.
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