I-Tachyphylaxis kunye nokunyamezela kunganciphisa impendulo nge-insomnia
Ukulala iipilisi kunokuba ngu-godsend: ekugqibeleni ubusuku bokulala emva kokubandezeleka ngenxa yobuthongo obude kakhulu. Kodwa esi sihluthulelo sinokuthi sifumane ixesha elifutshane, nangona kunjalo, oku kunokuba ngumthombo wokhathazeka nokuphelelwa yithemba. Yintoni ebangela ukuba iipilisi zokulala zingasebenzi ngaphaya kwexesha? Olu tshintsho lunxulumene nomgaqo kwi-pharmacology kubangela i- tachyphylaxis . Funda indlela i-tachyphylaxis, uhlobo lokunyamezela, litshintshe ukusebenza kweepilisi yakho yokulala kunye nento enokuyenza ngayo.
Ukuguqulwa koPhulo lweePilisi zokulala
Akuqhelekanga ukulala kwamapilisi ukuze usebenze kancane kancane xa unyango luqhubeka. Ekuqaleni, amayeza anika imiphumo emihle: ngobusuku bokulala okungaphazamiseki. Nangona kunjalo, ngokuthe ngcembe amayeza angabonakala eqala ukusilela. Ayingasebenzi ngaphantsi, kungabonakali ukusebenza njengaye. Unokufumanisa ukuba kufuneka ukhulise umthamo ukuze ufumane impembelelo efanayo. Kunokuba ufune enye ipilisi, uthabatha ezimbini. Ngexesha elide, kwanokuba ukunyuka kwelo dose akubonakali okwaneleyo. Iipilisi zokulala ziyeke ukusebenza ngokupheleleyo. Yintoni omele uyenze kwaye kutheni oku kwenzekayo?
Le nzekayo yenzeka ngenxa yenkqubo yemvelo ebizwa ngokuthi ukunyamezela. Nangona oko kungathi ngathi kuhambelana nomlutha, akufanelekile. Enyanisweni, ukunyamezela kudla ngokuphindaphindiweyo ekuphenduleni ukuqhubela phambili kwiyeza. Ibhekisela kwinto yokuba ukuvezwa kubangelwa impendulo ephantsi ngokunciphisa umlinganiselo ofanayo.
Khawucinge nje uhamba endlwini yakho kwaye uthabathe ukupheka kwesonka esitsha kwi-oven. Ngokukhawuleza emva koko, mhlawumbi ungaboni na ukuvumba. Ukuba uyaphuma ngaphandle uze ubuye, nangona kunjalo, kuya kubonakala kwakhona. Iqondo levumba alitshintshi; Umphenduli womzimba wakho kuwo, nangona kunjalo.
Ngendlela efanayo, umzimba wakho ngokuthe ngcembe ungaphenduli kangako kumlinganiselo ofanayo wepilisi yokulala.
Oku kunxulumene nometabolism. I-Metabolism yeziyobisi ixhomekeke ku-genetics yakho, ubudala, ubulili, uhlobo lomzimba kunye nezinye izinto. Ukuba uthatha iziyobisi ezithile, oku kunokubangela ukuba isibindi sakho okanye umsebenzi wezintso ziguqulwe, zichaphazele ezinye iyeza. Kwingqondo, iisensi zeentsimbi zingatshintsha inani kunye nokuphendula kwabalamkeli. Oku kunemiphumo ebalulekileyo kwimpembelelo yeepilisi zokulala. Ekuphenduleni kokunyanzeliswa okuqhubekayo kumachiza, umzimba wakho uzama ukunciphisa impembelelo ngokuthatha ama-receptors anxulumene nesilwayo. Emva koko, nakuba amanqanaba eziyobisi angafani, impendulo ayikho. Ngexesha, ipilisi yokulala ibonakala iyeka ukusebenza.
Isixa sithuba kule mpendulo siyahluka. Ukuba kwenzeka ngokukhawuleza, kuthiwa yi-tachyphylaxis. Ukuba ihamba ngokuthe gqolo, inokuthi ibhekiswe njengokunyamezela. Ezi zinto azihambelani nenye ingqiqo ebizwa ngokuthi kuxhomekeka (apho isicatshulwa ngokweengqondo okanye ngokomzimba ukuphepha ukukhutshwa okanye ezinye iziphumo ezimbi).
Esi sidingo esincinci sokwandisa umthamo sinokuyingozi xa singenziwanga ngenkxaso yogqirha wakho. Ngokukodwa, ukusebenzisa iipilisi zokulala ngotywala kungabhubhisa ukuba ukuphefumla kuyathinteka.
Ukuyeka iyeza ngokukhawuleza kunokukhokelela ekuphumeni kokulala, okusoloko kuphoqelela abantu ukuba baqhubeke nokunyango lwabo kwixesha elide. Oku kunokuba kukulungele iinkampani zonyango ezivelisa iziyobisi, kodwa mhlawumbi zingabonakali kakuhle kubantu.
Ziziphi iindlela ezikhoyo zokugwema iTachyphylaxis kunye nokunyamezela?
Ngethamsanqa, kukho iindlela ezinokuthi ziphephe i-tachyphylaxis kunye nokunyamezela nokusetyenziswa kweepilisi zokulala. Ukuba kunokwenzeka, kukulungele ukusebenzisa kuphela iipilisi zokulala ngexesha elifutshane (ezingaphantsi kweeveki ezimbini). Akufanele usebenzise amayeza amaninzi ukunceda ukulala kwakho ngexesha elifanayo. Umngcipheko wokudluleka ngokwexesha, ngokukodwa ekusetyenzisweni kotywala, kukuxhalabisa ngokwenene kunye nokonakala.
Kufuneka ulandele ukhokelo lugqirha wakho kwaye uqinisekise ngokucacileyo onke amayeza oyisebenzisayo ukunceda ulale.
Kwezinye iimeko, kunokufuneka ukuba ukwandise umthamo okanye utshintshe kancane kancane kwiyeza elitsha. Isimo esona sihle kakhulu siza kulandela ukukhetha unyango olungenalo unyango lwe-insomnia. Ngokukodwa, unyango lwe-cognitive-behavioral for sleepiness (CBTi) luye lwabonakaliswa ukuba lunempumelelo kakhulu kwixesha elide lokunyanga le meko. Ayinayo imiphumo emibi, ayigqoki, kwaye akukho nethuba lokufumana imiphumo engafunekiyo yokunyamezela kunye ne-tachyphylaxis.
Umthombo:
Katzung, BG Isisiseko kunye neKlinikhi ye-Pharmacology. I-9th edition, 2004. iphe. 31, 359. iMcGraw-Hill Companies, Inc. eNew York.
Kryger, MH et al . "Imigaqo kunye nokuSebenza kweMithi yokulala." I-ExpertConsult , umxholo we-5, ngo-2011.