Ulawulo lweZifo nguNjongo
I-Gout iyindlela enobunzima kakhulu ye-arthritis. Abantu abaninzi abaye bafumana ukuhlaselwa kwe-gout bachaza amava njengento ebalulekileyo, kwaye ngokwenene, baya kwenza malunga nantoni na ukuqinisekisa ukuba abanakho. Bafuna ukwazi indlela yokunyanga umuthi, kodwa ngaba kukho impela unyango?Uphi unyango?
I-Merriam-Webster Dictionary ichaza ukunyanga ngokuthi "ukubuyisela kwisifo; ukuxolelwa kweempawu okanye iimpawu zesifo ngokukodwa ngexesha lexesha elide lokujonga."
Ngokuhambelana nolu ngcaciso, unyango lwe-gout lubonisa ukuba unyango olufanelekileyo luvimbela ukuphindaphinda kokuhlaselwa kwe-gout. Ukuze uphilwe, izigulane zentsholongwane kufuneka ziphendule kakuhle unyango kwaye zihambelane nesicwangciso sonyango sexesha elide.
Ukuhlaselwa kwe-gout kukhula njengoko i- uric acid iqokelele emzimbeni kunye ne-uric acid crystals (i-monosodium urate i-monohydrate crystals okanye i-MSU) kwaye ifakwe kwiindawo kunye nezicubu ezithambileyo ezijikeleze amajoyina. Ukufakwa kwe-crystals kuhlanganiswe nokuqhaqhaqhaqhaqhaqhaqha kwaye kungapheliyo .
Akunabo bonke abantu abane- hyperuricemia abahlakulela i-gout: kuqikelelwa ukuba ukuya kwi-sibini yesithathu yabantu abane-hyperuricemia abazange bahlakulele iimpawu zekristali okanye iimpawu ze-gout . Sekunjalo, injongo yonyango lwexesha elide kukugcina i-serum uric acid engaphantsi kwe-6 mg / dl. Kulo nqanaba, ama-crystals amasha ayifaki, ama-crystals akhona ayanokutshabalalisa, ukuhlaselwa kwe-gout kulukhuni, kwaye i-tophi iyancipha kwaye iphela.
Okubalulekileyo, xa uric acid igcinwa ngaphasi kwe-6 mg / dl, kwaye yonke i-crystal deposits iyachithwa, igulane iyaphiliswa-nangona kungekho unyango oluqhubekayo, abaninzi abantu baya kuphinda babuyeke.
Ukuhlaselwa kweGout
Ngokuqala kokuqala kwesifo, intlungu kunye nokuvuvukala kuninzi kakhulu kwiiyure ezimbalwa zokuqala.
Nangona ukungaxoxwa, iimpawu ziphucula kangangeentsuku, mhlawumbi kuthatha iiveki ezimbalwa. Kwabanye abantu, ukuhlaselwa kwe-gout kulandelelwano kunokwenzeka, kunye neminyaka phakathi kokuhlaselwa. Njengoko ixesha liqhubeka, uhlaselo lwe-gout ludla ngokunyuka kwixesha. Uhlaselo ngalunye lunokuhlala ixesha elide kwaye lunokubandakanya amaninzi amaninzi.
Ukulawula i-Gout nokukhusela ukuphinda kuhlaselwa
Ukuhlanganiswa kwamachiza kunye nokutshintsha kwezondlo kusetyenziswa ukukhusela ukuphindaphinda kokuhlaselwa kwe-gout, okanye kwezinye iimeko, ukunciphisa amaxesha okuhlaselwa kwe-gout. Ukunciphisa amanqanaba e-uric acid ngokuqhelekileyo unjongo.
Abantu abanokuhlaselwa okungapheliyo okanye okunyanzelekileyo abanokuthi bangadingi imithi yokukhusela ixesha elide, kwaye bafumane ukunyangwa ngokukhawuleza njengoko kwenzeka. Kodwa abantu abahlaselwa yi-gout rhoqo, ixesha elide kunye nokukhubaza kungadinga ukuba imithi ilawule ukuphindaphinda.
I-NSAID (izidakamizwa ezichasayo ezingekho komzimba) zibhekwa njengomgca wokuqala wokukhusela ekuhlaselweni kwe-gout, ngaphandle kokuba izidakamizwa zingqiniswanga ngenxa yokungabikho komzimba okanye umlando wezilonda zamachiza , umzekelo. Ngokuqhelekileyo, ii-NSAID zingazisa ukuhlaselwa kwe-gout ngaphantsi kweeyure ezingama-24.
I-Glucocorticoids , ebizwa nangokuthi i-corticosteroids, iyindlela efanelekileyo yokwenza ukukhuselwa komdlavuza.
Ngokuqhelekileyo, ezi zonyango zichazwe kwiqondo eliphezulu ekuqaleni, emva koko zithatha iintsuku ezili-10 ukuya kwezi-14. Ngenxa yeziphumo ezimbi , i-corticosteroids iyisisombululo esifutshane, kungekhona ixesha elide.
UColchicine wayeyiphilisi ekhethiweyo ukuphatha ukuhlaselwa kwe-gout. Ngenxa yexesha elithathayo ukulawula ukuhlaselwa kunye nokwenyuka kwesifo sobungozi, i-colchicine ayisaphakanyiswa ukunyanga ukuhlaselwa kwe-gout, kodwa kusetyenziswa ukukhusela.
Ukuba kunqunywe ukuba isigulane kufuneka siphathwe ngesicatshulwa-sokunciphisa i-urate, kukho ukhetho oluninzi. I-Allopurinol yi-xanthine oxidase inhibitor eyanciphisa umveliso we-uric acid.
Iprobenecid yenye yee-oricosuric agents ezandisa ukwanda kwe-uric acid.
I-uloric (i-febuxostat) yinyango echanekileyo yokulawulwa kwe-hyperuricemia engapheliyo kwi-gout. I-uloric iyanciphisa i-serum uric acid ngokuthintela i-xanthine oxidase (i-enzyme echaphazelekayo kwimveliso ye-uric acid).
I-Krystexxa (i-pegloticase) yichiza ye- biologic efumanekayo kwizigulane ezingenakuzithatha, okanye abangenakuncedwa yi- gout . I-Krystexxa isebenza ngokuphula i-uric acid.
Imithombo:
Ulwazi olunomonde: I-Gout (Ngaphandle kweZiseko). Isemgangathweno. UMichael A. Becker. Matshi 29, 2012.
http://www.uptodate.com/contents/gout-beyond-the-basics?source=search_result&search=Gout+beyond+the+basics&selectedTitle=1%7E150
Ukunyanga ukujolisa: isicwangciso sokunyanga umuthi. UFernando Perez-Ruiz. Rheumatology. 2009.
http://rheumatology.oxfordjournals.org/content/48/suppl_2/ii9.full
I-Primer kwi-Rheumatic Diseases. Klippel, J. et al. Ipapashwe ngu-Arthritis Foundation. Uluhlu lweSithathu.