Uric acid , umkhiqizo oqhelekileyo, umphumo wokuphela kwe-purine metabolism. Iipilisi ziimichiza ezivela ngokwemveli ezifumaneka kwimibutho yethu kunye nokutya kwethu. Ngokuqhelekileyo, i-uric acid ichithwa egazini iqhutyelwa ngeentso kwaye isuswe emzimbeni kumchamo. Imeko, eyaziwa ngokuba yi-hyperuricemia (amanqanaba aphezulu e-uric acid), inokwenzeka xa kukho ukuncipha kwe-uric acid okanye ekuveleni ukwanda kwe-uric acid.
I-hyperuricemia inokubangelwa nokudibanisa kwe-under-excretion kunye nokwanda kwee-overproduction. I-akhawunti engaphantsi kwe-akhawunti yonyango lamaninzi e-hyperuricemia. Ama-akhawunti angaphezu kwama-altare amanani amancinci angama-hyperuricemia. Ukusabalalisa kwe-asymptomatic (ngaphandle kwempawu) i-hyperuricemia kuluntu jikelele liqikelelwe ukuba libe phakathi kwe-2% ne-13%.
Phantse kubini kwisithathu se-urate body (uric acid) iveliswa ngokugqibeleleyo (ngaphakathi emzimbeni), ngelixa isalathisi esele sithathwa yi-metabolism ye-purines. Ekubeni i-70% ye-urate eveliswa imihla ngemihla ixutywe yizintso, kunye nentsalela ekhutshwe ngamathumbu.
Uvavanyo lwegazi lwe-Uric
Uhlobo oluqhelekileyo lovavanyo lwegazi lwe-uric luphakathi ko-3.5 no-7.2 mg / dL. Kufuneka uqaphele ukuba ii-laboratories ezahlukeneyo zingaba neendawo eziqhelekileyo zokubhaliweyo. I-Hyperuricemia, ngokukodwa, ichazwa njengezinga legazi le-uric acid elingaphezulu kwe-7mg / dL lamadoda kwaye likhulu kune-6mg / dL yabasetyhini.
Uric Acid Crystal Formation
Nangona i-hyperuricemia ngokwayo ayiyiyo isifo, kwaye kwezinye iimeko azibangela ukuba kubekho iingxaki, ixesha elide le-hyperuricemia lingakhokelela ekuphuhliseni i-crystals. Yiyo i-crystal e-uric edibene ne-gout. Kodwa, nangokwazi oko, umbutho phakathi kwe-hyperuricemia kunye ne-gout akacaci ngokupheleleyo.
Izigulane ezininzi ezine-hyperuricemia aziyi kuba ne-gout - kwaye ezinye izigulane ezinokuhlaselwa kwe-gout eziphindaphindiweyo zinezinga eliqhelekileyo okanye eliphantsi legazi le-uric acid. Ipesenti encinci yabantu abanomdla wokuxhomekeka kwegazi ngokuqinisekileyo bayaqhubeka nokuphuhlisa igciwane.
Ama-crystals ama-uric acid, xa afakwa kwiingxube, angabangela intlungu edibeneyo, ukuvuvukala okuhlangeneyo, ukuqina okuhlangeneyo, ukukhubazeka ngokuhlangeneyo, kunye nokuhamba okuthe ngqo. Ukuba i-gout ikhula, iikholeji yase-American College of Rheumatology ekulawuleni i-gout (2012) incoma ukuba amazinga e-uric acid agcinwe kwinqanaba elingaphantsi kwe-6 mg / dL ukukhusela ukuhlaselwa kwe-gout ephindaphindiweyo.
Iikridi ze-uric acid nazo zingafakwa kwiinsso. I-uric acid crystals kwizintso zingabangela amatye eentso ukuba ayenze kwaye angakhokelela kwisifo sentso okanye ukungaphumeleli kwezintso.
Izinto ezinobungozi ezinxulumene ne-Hyperuricemia
I-hyperuricemia idibene nemingcipheko, njenge-dysglycemia (ingxaki yeswekile yegazi), i-dyslipidemia (iingxaki ze-lipid), ukukhuluphala, kunye noxinzelelo lwegazi olungaqhelekanga - kunye nolwazi olubizwa ngokuba yi-syndrome. I-hyperuricemia ingabangelwa yindlela yokuphila engafanelekiyo, ngokukodwa, ukutya okunomsoco ophezulu kwi-purines, iprotheni, utywala kunye ne-carbohydrate.
Ngekubeni kubalulekile ukuthobela ingqalelo kwiimeko ezinobungozi, ezifana nokutya kunye nendlela yokuphila, yodwa yodwa ayinakho ukulawula ukuxhatshazwa kwegazi.
Kwakhona kuyaphawuleka ukuba amanye amayeza anokwandisa umngcipheko we-hyperuricemia, kuquka i-thiazides, i-loop diuretics kunye ne-aspirin ephantsi.
Ngaphantsi
Ixesha elide le-hyperuricemia, okanye i-hyperuricemia engapheliyo, idibene nomngcipheko omkhulu wokuphuhlisa umtshi. Ukukhutshwa kwe-Crystal yiphumo loxinzelelo lwe-hyperuricemia engakhokelela kwisifo okanye isifo sesifo. Ukugcina igazi lezinga le-uric acid elingaphantsi kwe-6 mg / dL kubalulekile ukuba abantu baxilongwe benomdla wokukhusela ukuhlaselwa okuphindaphindiweyo.
> Imithombo:
> Uric acid - Igazi. MedlinePlus. 4/29/2013.
> I-Hyperuricemia engapheliyo, i-Uric Acid, ne-Cardiovascular Risk. Grassi D. et al. IsiCwangciso seMichiza. Epreli 2013.
> Gout kunye Hyperuricemia. KwiSizwe seNtloko.