Ukusetyenziswa okukhuselekileyo kwe-colchicine kunciphisa imiphumo engafunekiyo
I-Colchicine yonyango olukhethiweyo lwe-arthritis ye-gouty. Nangona isicatshulwa sisona sikhewu esibalulekileyo sokonyango lwe-gout , kukho ininzi engaqhelekanga malunga ne-colchicine. Ngokomzekelo, indlela i-colchicine isebenza ngayo, ukususela apho itholakala khona, ibe nexesha elingakanani inomdla, kwaye kubaluleke kakhulu, okokufuneka ukwazi ukusebenzisa isilwanyana ngokukhuselekileyo.
Iinkcukacha ezibalulekileyo malunga neColchicine yeGout
1.
I-Colchicine i-alkaloid ephuma kwimbewu eyomileyo ye-Colchicum autumnale, eyaziwa nangokuthi i-crocus ekwindla okanye i-saffow safari.
Ukusetyenziswa kwe-Colchicum alkaloid ukunyangwa kwe-gout ephawulekayo kubuya ngo-1810. Ukuxabiswa kwe-colchicum kwaxelwa kwakhona kwi-yokuqala ye-AD AD iColchicine isetyenziselwe ukulawula imeko ngaphandle kwe-gout, kuquka:
- Amyloidosis
- Isifo seBehcet
- Dermatitis herpetiformis
- Imfiva yaseMediterranean
- Isifo sePaget
- Pericarditis
- Inkcazo
- I-Biliary ne-hepatic cirrhosis
2. I-Colchicine ifumaneka kwiidayimenti zomlomo okanye ezingenayo.
I-Colchicine ifumaneka kumandla amabini omlomo - i-0.5 mg kunye neephilisi ze-0.6 mg. Isilwayo sifumaneka ngaphakathi kwangaphakathi, kodwa kukho ukusetyenziswa kwesifo esinobungozi obukhulu usebenzisa umzila we-parenteral (okt, i-intravenous okanye injection, umzila ngaphandle kwendlela yokugaya).
3. I-Colchicine inezakhiwo ezichasayo, kodwa ukusetyenziswa kwayo kwiintlobo zentlungu ngaphandle kwe-gout kuyancinci.
Nangona i-colchicine ithathwa njengempumelelo kakhulu ekunyangeni i-arthritis enamandla, ayinakusebenza kuzo zonke iintlobo zentlungu. I-Colchicine ayithathwa njengesicatshulwa (isib., I-painkiller). Kwakhona ayichaphazeli imvume ye-uric acid .
4. I-Colchicine isebenza ngokuhlukileyo kunezinye iintlungu zokuxhoma okanye izidakamizwa ezichasayo.
I-Colchicine ibopha kwiiprotheni kwii-microtubules ze-neutrophils. I-neutrophils yimihlobo yegazi elimhlophe . Ngokubopha i-neutrophils, iiseli azikwazi ukufudukela kwindawo yokuphendulela okuvuthayo kwi-uric acid crystal deposits. I-Colchicine inefuthe elixhasayo elinceda ukunciphisa ukuhlaselwa kwe- gout acute, ngaloo ndlela iyanciphisa intlungu kunye nokungahambi kakuhle kunye ne-gout.
5. I-Colchicine iphinda ikhuthazwe ukuba isebenzise rhoqo phakathi kokuhlaselwa njengomlinganiselo weprophylactic kwaye inokusebenza ekunqandeni ukuhlaselwa xa kuthathwa uphawu lokuqala lokungahambi kahle.
I-dose evamile yokunciphisa ukuhlaselwa kwe-gout i-1 ukuya ku-1.2 mg (ezimbini 0.5 mg okanye iipilisi ezimbini ze-0.6 mg). Eli dosi linokulandelwa liyunithi enye yecwecwe yomelela nganye kwiyure, okanye iiyunithi ezimbini kwiiyure ezimbini ukuya kube yintlungu. Emva kwesibalo sokuqala, ngamanye amaxesha kunelungelo lokuthatha i-0.5 okanye 0.6 mg nganye iiyure ezimbini okanye ezintathu. Isiza kufuneka simiswe ukuba kukho ukungaxhamli kwamathumbu okanye isifo sohudo.
6. I-Colchicine ingalawulwa ngokuqhubekayo njengonyango lokukhusela.
Kwizigulane ezinokuhlaselwa ngaphantsi kwe-gout ngonyaka, umthamo oqhelekileyo ngowama-0.5 okanye 0.6 mg ngosuku, iintsuku ezintathu okanye ezine ngeveki. Kulabo abanokuhlaselwa okungaphezu kweyodwa ngonyaka, i-dose eqhelekileyo i-0.5 okanye 0.6 mg imihla ngemihla.
Iimeko ezinzima zingadinga ezimbini okanye ezintathu ezintathu mg okanye iipilisi eziyi-0.6 mg imihla ngemihla.
7. Ukuphendula okungalunganga kunokwenzeka ngokusetyenziswa kwe-colchicine kwaye kubalulekile ukuba uqaphele loo nto.
Ukudakumba komnxeba we-Bone , ne-anemia ye-aplastic, ne-agranulocytosis, okanye ne-thrombocytopenia inokuvela kwizigulane ezithatha unyango olude.
Ezinye iimpendulo ezingalunganga ziquka:
- Neuritis neuritis
- Purpura
- Myopathy
- Ukulahleka kweenwele
- I-azoospermia yokuguqulwa (ukungabikho kwe-sperm)
Ukuvuthwa, isifo sohudo, kunye nesicathulo somzimba sinemiphumo emibi engenzeka nge-colchicine therapy, ingakumbi xa i-doses ephezulu imiselwe.
8. Abafazi abakhulelweyo kufuneka balinganise ingozi kunye neenzuzo zokusebenzisa i-colchicine.
I-Colchicine ifanele isetyenziswe ngexesha lokukhulelwa kuphela ukuba inzuzo enokuthi ifaneleke ingozi ebantwini. I-Colchicine inokubamba isahlulo seseli, ngoko kuya kuba ngumngcipheko omkhulu ukuthabatha izilwanyana ngelixa ukhulelwe. Iseluleko kufuneka sisetyenziswe xa i-colchicin ilawulwa yinkwenkwe engumnesi.
9. I-Colchicine akufanele isetyenziswe zizigulane ezithile.
I-Colchicine ayifanele isetyenziswe ngumntu onokwakheka kwe-hypersensitive kwi-drug, okanye ngesigulane esinomzimba osisigxina, isithintelo, i-hepatic, okanye i-heart disease. Kwakhona, izigulane ezineengxaki zegazi akufanele zisebenzise i-colchicine.
10. I-Colchicine idinga isigqirha esibhalwe ngugqirha wakho.
I-Colchicine yonyango lonyango elitholakalayo kwifomu yobudala kwaye njengegama lomenzi wegama, iColcrys (i-tablet ye-0.6 mg). Ukunciphisa iziphumo zecala, i-colchicin ingathathwa ngokutya.
Imithombo:
Colchicine. RxList. I-Internet Index yeDrug. Uhlaziywe 10/04/2010.
http://www.rxlist.com/colchicine-drug.htm
Colchicine. MedlinePlus. 02/01/2010.
https://www.nlm.nih.gov/medlineplus/druginfo/meds/a682711.html
Colcrys. Uhlaziyo lwe-12/2015.
https://www.colcrys.com/
I-Kelley's Bookbook yeRheumatology. Elsevier. I-ninth edition. Isahluko 95: Iimpawu zeCliniki kunye noPhando lweGout - Colchicine.