I-Singulair, i-Accolate, i-Zyflo kunye ne-Zyflo CR ziye zaguqula iileyibhile zabo zokufaka uluhlu ngolwazi malunga neminye yemiphumo yempembelelo yempilo yengqondo eye yabonwa kwizigulane ezisebenzisa le mveliso. Iimpawu ukuba izigulane kunye nababoneleli ngeenkonzo zezempilo kufuneka bazi ukuba ziquka:
- ukuxhalaba
- ulwalamano
- ukuxhalaba
- ukuphupha okungaqhelekanga
- ukucoca
- ukuxinezeleka
- kulala
- ukucaphuka
- ukungazinzi
- ukucinga nokuziphatha okuzibulala
- ukuzibulala
- ukuthuthumela
Ukuba ubona naziphi na ezi ziphumo zempembelelo kufuneka uqinisekise ukuba uthetha ngokukhawuleza kunye nodokotela oyalela. I-FDA ineziphakamiso ezilandelayo kwizigulane kunye nababoneleli malunga nemiphumela yecala le-Singulair kunye nemiphumo emibi yezinye i-leukotriene modifiers:
- Izigulane kunye nabaqeqeshi bezempilo kufuneka baqaphele ukuba iziganeko ze-neuropsychiatric ziza kwenzeka kunye nala mayeza.
- Izigulane kufuneka zithethe nababoneleli ngezempilo ukuba ezi ziganeko zenzeka.
- Abasebenzi bezempilo kufuneka baqikelele ukuyeka loo mayeza xa izigulana zikhula iimpawu ze-neuropsychiatric.
Ulwazi olutsha lwamalungiselelo kule mveliso lunokufumaneka kwiwebhusayithi ye-FDA.
Ngaba zikhona iindlela ezingasetyenziswayo kwi-Singulair?
Nangona engekho inxalenye yezikhokelo ze-asthma zangoku, kukho ubuncinane enye enye i-Singulair xa ufumana imiphumo emibi okanye ungafuni ukuthatha amayeza.
Okuthakazelisayo akuyiyo nkunkuma, kodwa kunokutya kwezokwelapha .
Izinto zokutya zonyango zichazwe phantsi kwe-Orphan Drug Act kwaye zilawulwa yi-US Food and Drug Administration (FDA). Njengoko kuzwakala, ukutya kwezokwelapha kuyimveliso enenjongo yokusebenza njengonyango ngokunyusa njengoko uthanda ukunye ukutya.
Esikhundleni sokutya ukutya okunempilo, oku kutyalwa ngokukhethekileyo ukuphucula isifo. Ngokufanayo, oku akusikho ukutya oza kuwathabatha kwivenkile. I-FDA ithi udinga ukuba phantsi koxanduva lugqirha kwaye kufuneka ukuba ilandele ngokuqhelekileyo njengoko ufuna ukuyenza kunye nayiphi na imithi ye-asthma.
Kule meko, i-Lunglaid yinto yokutya yonyango eyenzelwe ukunciphisa amanqanaba e-leukotriene. Uluntu olujoliswe kule ndawo yokutya lwezokwelapha ngabantwana abane- asthma abalawulwa kakubi abangafuniyo okanye abanako ukunyamezela i-Singulair.
Kwiimvavanyo zeclini, i-Lunglaid ibonise umgangatho wobomi obuphuculweyo kunye nokunciphisa amanqanaba e-leukotriene. I-leukotriene homeostasis yabangela ukuqina kancinci kwesifuba , ukukhwehlela, ukuphefumula okufutshane kunye nokujikeleza . Izigulane ezithatha i-Lunglaid zaqatshelwa ukuba zixhamle imisebenzi, imidlalo, imisebenzi yentlalo kunye nokufumana ukulala okuphuculweyo. Kwakhona, imiphumo engathandekiyo yayingaqhelekanga kwiqela elonyango lonyango kunokuba beliqela le-placebo. Uninzi unyango lwe-asthma, kunye nezo ziphumo ezincinci kakhulu, zinomphumo ofanayo ukusuka kuloo mbono.
Umthombo:
I-FDA Ulwazi lwezoKhuseleko lweMatriki. Ulwazi olubuyekeziwe malunga ne-Leukotriene Inhibitors: i-Montelukast (ithengiswa njenge-Singulair), i-Zafirlukast (ithengiswa njenge-Accolate), kunye ne-Zileuton (ithengiswa njengeZyflo kunye neZyflo CR)
I-Lunglaid Clinical Studies.