Iintsapho Zakho zichaphazela ingozi ye-Asthma
Uphando lubonisa ukuba ngaphezu kwesigamu seengxaki ze-asthma zengane zihlobene nelifa (intsingiselo yokuba rhoqo umzali okanye ilungu lentsapho lalinalo okanye une-asthma). Iingcali zenzululwazi ziye zachonga iindidi ezahlukileyo ezahlukahlukeneyo ezibonakala zidlala indima kwi- pathophysiology ye-asthma okanye idibanisene neziphumo ezithile. Ngokungafani nezifo ezininzi ezikhoyo ngoku ukubonakaliswa kwezifo zengqondo azange zikhokele kwiimvavanyo zonyango , iindlela ezithile zokwelapha okanye ukuqonda ukuba izigulane zingasabela njani kwiimpawu ezithile zonyango njengoko kuboniswe kwezinye iisomhlaza.
Okwangoku, akubonakali ukuba ukuchongwa kwanoma yiyiphi i-gene esisodwa kuya kukhokelela kwipilisi enjalo, kodwa kukho ithemba lokuba ukujoliswa kwamagqabantshintshi ezinjengeentlobo zezityalo kungase kube yindlela ethembisayo. Phantse isiqingatha sazo zonke i-asthma zivakalelwa ukuba zibangelwa yimicimbi yendalo.
Impembelelo eminye yemingcipheko yandisa umngcipheko we-asthma , nayo. Ngokuqinisekileyo i-Genetics ichaza ezinye, kodwa akuzona zonke iimeko ze-asthma. Okungakumbi, nokuba awuyikuhlaziya i-asthma kuxhomekeke kwintlangano yemingcipheko ehambelana no:
- Genetics
- Ingqongileyo, njengokungcoliseka komoya
- Immunology, kunye nesistim sakho sokuzivikela
I-Genetics icingelwa ukuba mhlawumbi ichaze ezinye zeentlukwano ezibonwe kumaqela achaphazeleka yi-asthma. Nangona i-asthma ivame ukuba nefuthe kubantwana balabo abanamazinga aphezulu emfundo kunye neengeniso, isixeko sangaphakathi, ama-Afrika-aseMerika abonakala bebangele ingozi. Abanye bacinga ukuba oku kungenziwa ngenxa yokukhuselwa komzimba kunye nokuvezwa kwimeko ethile yokusingqongileyo njengento yokutya i-cockroach.
Imbali Yentsapho ne-Asthma
I-Genetics ingaba nzima kakhulu kwaye kunzima ukuyiqonda. Nangona kunjalo, unokucinga ngoku ngokumbuza umbuzo omnye: Ingaba imbali yentsapho ye-asthma yandisa umngcipheko wokuba nesifo se-asthma? Makhe sibone.
Ukuba nomzali omnye one-asthma kwandisa umngcipheko womntwana wokuba nesifo se-asthma, ngoxa abazali bobabini abane-asthma bandisa umngcipheko wengane ngokuphindwe kathathu.
Ngokufanayo, imbali yentsapho ye-asthma phakathi kwabantu abadala kwintsapho nayo iboniswe ukwandisa umngcipheko wokuba nesifo se-asthma.
Kukho inani lezinye izizathu ezibangelwa yi-Asthma Causes
I-asthma yenzeka kwimiqathango eyahlukeneyo, kodwa izizathu zokungafani ezibonwayo aziqondwa kakuhle. Nangona i-asthma ifuthe kumntwana omnye kwabantwana aba-7, abantu abadala bafumana i-asthma. I-asthma echaphazela abantwana ibaluleke kakhulu, ehlala ihluke kakhulu kune-asthma echaphazela abantu abadala. Ezinye izigulane zibonakala zixhomekeke kwizifo ezinzima okanye ingozi enkulu yokuphazamiseka ngokukhawuleza kwe-asthma yabo. Ekugqibeleni, i-asthma eyenzeka ngenxa yezizathu zoshishino (ukupheka kwebhaki kwipuphu ebhaliweyo okanye abapendeli abaphendula kwiimpawu zepende ezenziwe ngefestile.
Indlela yokuphila yasemaphandleni Ukukhusela i-Asthma
Ngakolunye uhlangothi, siyazi ukuba izinto ezithile zingakhusela nokukhuselwa kwisifo se-asthma. Uphononongo lubonisa ukuba ukukhula kwendawo yasemaphandleni kubonakala kukukhusela i-asthma. Ukuphila eplasini kunye nokusebenzisana nezilwanyana zasefama kunye nokusela ubisi obungasetshenziswanga kubandakanywa nomngcipheko ophantsi we-asthma. Oku akunjalo nje e-United States; Ukukhula kwipulazi e-Afrika kubonakala kukukhuseleka okufanayo. Ukuba ukhula kweso sixeko, ukuba nezilwanyana kunye nabantakwabo abaninzi zibonakala zikhusela ukuphucula isifuba.
Zonke ezi mboniso zivame ukuxhasa i-Hygiene Hypothesis echaza ukuba ukuchasana nemibonakalo ebuntwaneni buntwaneni kunciphisa umngcipheko we-asthma.
Ngaba Ndifuna Ukuhlolwa Kwemvelo?
Mhlawumbi akunjalo. Iprojekthi ye-Human Genome iholele ekuqhubekeni kwezesayensi ezininzi kunye nokulandelelana kwegciwane lomntu. Uhlalutyo lokuxhunywa luhlobo lovavanyo olujongeyo ukuba lubone ukuba kunezifo ezingafaniyo zofuzo kwizigulane ezinezifo ezithile. Inani lezi zifundo liye laqulunqwa kwi-asthma kwaye zichongiwe imimandla ezili-10 ezinokuthi zibe nefuthe kwi-asthma. Uninzi lubonakala luba nenendima ethile ekuphuhlisweni okanye kwisisombululo seethambo kwi-epithelium yokuphefumula.
Ezinye iigesi ziye zachongwa ngokuthelekisa iigleji zezigulane ezine-asthma kwizigulane ezingenazo i-asthma. Ngokufanayo, uphando olujongene neentlanga ezahlukileyo luye lwafumanisa neendidi ezahlukahlukeneyo ezinokuthi zibandakanyeke kwi-asthma. Ekugqibeleni, uphando oluthile lubhekiselele ekusebenzisaneni kwemvelo. Ngokomzekelo, ubukho bezinto ezithile zohlobo lwezofuzo ezidibaniswe nokuchazwa kwentambo yengqumbo yengqungquthela kuboniswe ukuba kwandiswe ingozi ye-asthma xa kuthelekiswa nezigulane ezingabonakali kwimiba yengqumbo yengqumbo.
Ngoko, i-genetics idlala indima ebalulekileyo ekuphuhliseni i-asthma kodwa akuyona yodwa ingozi okufuneka uyiqwalasele. Unokuthetha nogqirha wakho ukuba ucinga ukuba nomntwana kwaye ufuna ukuzama ukukhusela isifo sokugula emntwaneni omncinane. Kukho amanani amanqanaba ahlukeneyo ongayithatha.
Imithombo:
UBracken MB, uBelanger K, i-Cookson WO kunye. al. Iziphumo zobungozi be-Genetic kunye nePerinatal ye-Asthma Onset and Severity: Ukuhlaziywa kunye noHlolo lokuHlola u-Epidemiol u-2002 24: 176-189.
UDuffy DL, uMartin NG, uBattistutta D, i-Hopper JL, uMathews JD. I-Genetics ye-asthma kunye ne-fever fever kumawele ase-Australia. Ngaba u-Respect Respir Dis 1990, 142: 1351-8.
I-Litonjua AA, i-Carey VJ, HA Burge, i-Weiss ST, i-Gold DJ. Imbali yabazali kunye neengozi yokufumana isifuba somntwana Ngaba uMama unalo mngcipheko olungaphezu koBawo? > Am. J. Ukuphefumula. Crit. I-Med Med., Umqulu 158, Inombolo 1, Julayi 1998, 176-181
I-Bottema RW, Reijmerink NE, Kerkhof M, Koppelman GH, Stelma FF, Gerritsen J, Thijs C, Brunekreef B, van Schayck CP, i-Postma DS. I-Interleukin 13, i-CD14, isilwanyana kunye nefuthe lokubhema umsila kumathathu amathathu aseDutch: uphando lwe-allergenic. UJur Respir J. 2008; 32 (3): 593.
Hu F, Persky V, Flay B, uRichardson J. (1997) Ukufundwa kweengxaki ze-asthma ukuxhaphaka kunye nezinto ezinxulumene nabantu abadala. I-Asthma, 34, 67-76.