Imbali yeNgxabano NgokweMveli yeTrgys
Ayikho imfihlo yokuba izidakamizwa ze-thyroid zemvelo (NDT) ziye zaphikisana ngamawaka eminyaka. I-NDT ifom ye-prescription ye- thyroid i-hormone esikhundleni sayo kwaye ibizwa ngokuba yi- thyroid yemvelo , i-thyroid ye-extract, i-thyroid ye-porcine, "i-pig thyroid," okanye ngamagama e-brand ezifana ne-Nature-throid okanye i-Armor Thyroid.
I-NDT yaqala ukuhlaziywa ekuqaleni kwee-1900 kwaye yenziwe kwiingqungquthela ze-thyroid ze-thyroid (indlela) yokwelapha i-hypothyroidism, ukusilela kwe-hormone ye-thyroid.
Iifom zokuqala ze-thyroid ezivela kwintsholongwane ye-thyroid, kodwa ekuqaleni kwee-1900, inkampani yezilwanyana zenyama yafika entsimini, ukuthengisa i- thyroid yendalo ephuma kwiihagu, eyaziwa ngokuba yi-Armor Thyroid.
Ngenxa yokuba yaveliswa ngaphambi kokuba i-FDA ikhona, umyalelo wayo njengemithi yonyango yayininzi, kwaye i-thyroid ekhethiweyo yendalo, ngoxa ilawulwa yi-FDA, ayizange ihambe kwiNkqubo " yeNtsha yokuSebenzisa iziDakamizwa " (i-NDA) eyayifunwa ngamachiza amatsha yaziswa kwiimarike emva kokuba i-FDA yasungulwa.
I-thyroid echithwe ngokwemvelo iqukethe i-T4 (thyroxine) kunye ne-T3 (triiodothyronine), kunye ne-calcitonin, kunye nezinye izinto ezitholakala kwi- thyroid gland . I- thyroid yegciwane evamile ivelisa ngokuyinhloko i-T4 (i-hormone yokugcina) kunye ne-T3, kunye ne-T4 iguqulwa ibe yi-T3, i-hormone esebenzayo, ukuze isebenziswe ngamaseli kunye nezicubu zomzimba.
Ukunyuka kweSystem
Ngethuba lephakathi kwekhulu leminyaka elidlulileyo, unyango lwe-thyroid lwamaqondo lwaluza kwi-market.
Le nguqu ye-synthetic ye-hormone ye-T4 yaziwa ngokubanzi njenge-levothyroxine, kwaye ngamanye amaxesha ibizwa ngokuba yigama eliqhelekileyo legama, iSythroid. U-Levothyroxine wanda kakhulu, kwaye ngekota yesibini ye-20, yaba yonyango olukhethiweyo kuluntu oluqhelekileyo lwezonyango.
Oogqirha bathi bomelele kwaye bengahambelani ne-thyroid echongiweyo, kwaye umzimba wakwazi ukuguqulela i-T4 kwi-T3 esebenzayo umzimba kufuneka ulungise i-hypothyroidism.
Kwiminyaka emininzi, izigulane ezininzi ze-thyroid zachongwa ngamachiza e-levothyroxine ukuphatha i-hypothyroidism. Kodwa njengoko inzala ikhula kwimithi yendalo kwiminyaka yee-1980, oogqirha abadibeneyo kunye nabaninzi baqala kwakhona ukumisela i-thyroid echongiwe yendalo, eyayihlala kwimarike, nangona isabelo esincinci semarike.
Abanye oogqirha asebekhulile ababekade basebenzisa i-thyroid echongiweyo yemvelo kunye nezigulane zabo nazo, batshintshe ezinye izigulana kwakhona kwizilwanyana zonyango ezichongiweyo zemvelo Ezinye zezi zi gulane zikhalazile, emva kokuba zitshintshelwe kwi-levothyroxine, ukuba iimpawu zabo zenzeke ngakumbi okanye zingenako ukuzisombulula .
Nangona izigulane ezininzi ze- thyroid kunye namagqirha abazange baqaphele ukuba kukho naluphi na ukhetho olungaphandle kwe-levothyroxine ukunyanga i-hypothyroidism, kuma-1990, ukuqaphela i-NDT njengokhetho lwandisiwe, ngenxa yezizathu ezininzi:
- ukunyuka kwe-Intanethi
- ukwandisa ukufikelela kwesigulane kwezinye izigulane
- ukwandiswa kokwabelana ngolwazi phakathi kwezigulane kunye noogqirha
Ukwandisa, izigulane ze-thyroid ezingenelisekile zithatha i-levothyroxine zazi ngakumbi ukuba izidakamizwa zendalo zonyango zangezinye i-levothyroxine.
Ukusetyenziswa kwezi zidakamizwa kwanda, kwaye ezinye izigulane zifumene ukuba iimpawu zabo kunye namazinga egazi le-thyroid , zilawulwa kangcono kwi-thyroid echongiweyo yemvelo, xa kuthelekiswa ne-levothyroxine, okanye i-levothyroxine kunye nefomu yokwenziwa kwe-T3 (igama legama nguCytomel, kwaye ngokubanzi yaziwa ngokuba yi-liothyronine.)
Ukuphikisana kwanda njengoko izigulane zabuza i-thyroid yezinto ezendalo, kunye nabasebenzi abaninzi, ngakumbi abo banokugxininisa ngakumbi, bawunikwe. Iingcamango ezingekho kakuhle, kunye noogqirha abathile bengaziboni ukuba izidakamizwa zemvelo zonyango zifumaneke ngaphandle kwemithi okanye zenziwa kwiinkomo, kwaye ngoko yengozi.
Izikhokelo zonyango ezisemthethweni zinconywa i-levothyroxine kwaye zonakalisa ngokukodwa ukusetyenziswa kwezidakamizwa ze-thyroid zendalo.
Kodwa kunjalo, njengokuba kuxhotywe ngesigulane nolwazi lukhuphuke, kwaye njengeyeza elipheleleyo kunye nelinye liye lafumana indawo enkulu, inani leemfuno zezilwanyana zonyango zendalo zanda. I-lab, Uphando lweNtshona, olwenziwe ngezilwanyana ezinobungozi be-thyroid I-nature-throid ne-Westhroid (ngoku i-WP Thyroid), yathengwa ngeRLC Labs, kwaye la mayeza amabini afumana inxaxheba enkulu yemarike.
Izikhokelo zemihlahlandlela ye-Clinical Practice ye-Hypothyroidism kubantu abadala , eyanyatheliswa yi- American Association of Clinical Endocrinologists (AACE) kunye ne- American Thyroid Association (ATA), i-thyroid ye-nature echanekileyo. Ingxubusho yengxoxo ye-Guideline ye-thyroid yemvelo isishwankathelwe kweli nqaku, kodwa ngokuqinisekileyo, baqhubeka besichazela ngephutha ukuba izidakamizwa ze- NDT zivela kwiinkomo, kwaye bazama ukuvala isihloko esithi "Akukho bubungqina obuxhasa ukusebenzisa i-thyroid ekhethiweyo i-hormone ngokukhethekileyo kwi-L-thyroxine monotherapy ekuphatheni i-hypothyroidism kwaye ngoko kuchazwe i-hormone ye-thyroid akufanele isetyenziswe kunyango lwe-hypothyroidism. "
Akwazanga ukukhankanya ukuba akukho bungqina obuxhasa ukusebenzisa i- levothyroxine ngokukhethekileyo kwi-thyroid echongiwe yendalo. Uphando aluzange lwenzeke ngandlela-thile, ngoko ke, iminyaka yemikhuba, imfundiso, kunye nokuthengiswa kubonakala ngathi yindlela yokuqhuba iziphakamiso zabo, kungabikho iziphumo ezivela kuphindwe zimbini, eziphindiweyo, iincwadi eziphandwayo zophando.
Ukuthelekisa i-Levothyroxine kunye neNdalo echazwe yiTroid
Uvavanyo olusandul 'ulungelelaniso, oluphindwe kabini, olusisimfama, luhlolisisa i-thyroid ye-levothyroxine. Uphononongo lwavavanya izigulane ezingama-70 (abaneminyaka eli-18 ukuya ku-65) ababenomphambili we- hypothyroidism . Izigulane zanikwa i-thyroid okanye i-levothyroxine ngeeyure eziyi-16.
Ekugqibeleni isifundo, izigulane zacelwa ukuba yiyiphi i-regimen abayifunayo, kwaye phantse ama-49 ekhulwini akhetha i-thyroid eyenziwe yendalo, malunga nama-19 ekhulwini abakhetha i-levothyroxine. Phantse iipesenti ezingama-33 azizange zichaze okokukhethayo. Izigulane ezithatha i-thyroid ezichithwe ngokwemvelo zalahlekelwa malunga neekhilogram ezintathu, xa kuthelekiswa nezigulane ezithatha i-levothyroxine , ezingazange zinciphise umzimba.
Ukuba uphando lwenziwa kwi- Endocrine Society ; oluphuhliso olubalulekileyo nolubalulekileyo kwizigulane ze-thyroid . Izigulane kunye nabagqirha banelungelo lokumisela kwaye bathathe nantoni na uhlobo okanye uhlobo lweyeza le-hormone ye-substituted medicine isebenza ngokukhuselekileyo kwaye lungcono kwisigulane ngasinye.
ILizwi
Ukuba unomdla ekuhloliseni i-NDT njengonyango lwe-hypothyroidism yakho, khumbula engqondweni:
- Kusenokwenzeka ukuba usebenze kunye nodokotela odibeneyo okanye opheleleyo, ngokuchasene ne-endocrinologist.
- Kufuneka usebenze ngutitshala onobungcali ekumisela i-NDT, nokulawula izigulane kwi-NDT.
- Akukaze kube yinto efanelekileyo yokuthenga izidakamizwa ezisemagqagaleni, ngaphandle kwemigomo, kwaye uwathathe ngaphandle kokongamela ugqirha.
- I-over-counter-counter-glandular supplementary supplements ayifuni i-NDT, kwaye ayifaki indawo yeyeza ye-hormone ye-hormone.
> Imithombo:
> Hoang TD. "Inkcazo ye-thyroid ecaciswe ngokuqhathaniswa ne-levothyroxine kwonyango ye-hypothyroidism." I-American Thyroid Association (ngoMatshi, 2013).