Indlela Yakho Isikhumba Ne-Immune System Sebenza Ngamanye Ukuze Uhlale Unempilo
Iiseli zeLangerhans (LCs) zifumaneka kwesikhumba (i- epidermis kunye ne- dermis ) yokuphefumula, i-digestive kunye ne-urogenital tracts. Banokufumaneka nakwezinye iisculi ezifana ne-lymph nodes, ngakumbi xa imeko yeLangerhans yestiocytosis (LCH) ibandakanyeka.
I-LCs inokukunceda ngokugcina ama-antigens anobungozi (nayiphi na into eyenza i-immune system ivelise ama-antibodies malunga nayo) ukungena emzimbeni wakho.
ILangerhans Iiseli zisebenza njani
Efunyenwe ngumfundi wezobugqirha waseJamani oneminyaka engama-21, uPaul Langerhans, ngowe-1868, iiseli zeLangerhans zikhoyo kuzo zonke izigaba ze-epidermis kwaye ziyamalungu entsapho ye-dendritic. Amaseli e-Dendritic amangamajoni omzimba anika ama-antigens kwisistim somzimba kwaye atholakala kuwo wonke umzimba. Ii-LC ziyi-cell e-dendritic esikhumbeni kwaye ekubeni iiseli ze-dendritic zisebenza kakuhle xa zihlaziya isistim sokuzivikela kwisifo sezilwanyana kunye nezinye izixhobo zangaphandle, ulusu luyimqobo ebalulekileyo ekukhuselweni.
Ii-LCs zacatshangelwa ukuba ziyinxalenye yesimiso se-nervous kwaye ziqaphele kuphela i-immune system kuma-antigen. Kunoko, uphando lufumene ukuba i-LC iyanciphisa ukusabela kwesikhumba kwintsholongwane nokuvuvukala kweendlela ezimbini ezihlukileyo:
- Ngokukhusela isikhumba sakho kwintsholongwane.
- Ngokuvuselela ukuphendulwa kwemizimba.
Iiseli ze-Langerhans zithumela ii-agents ezikhethekileyo-iiseli zomzimba ezifana neeseli ze-T neeseli ze-B-ngokukhawuleza emva kokubona nayiphi na ingozi kwesikhumba.
Amasosha omzimba athabatha abenzi bezono ezifana neebhaktheriya kunye neentsholongwane kwaye balwe nokulimala njengamaqhekeza kunye neentlobo.
Imeko yesikhumba ilisoloko ilandelwa yi-LCs kwiimeko ezingaphephile kwaye iiseli zomzimba zithunyelwa ukubuyisela ulwazi malunga nawuphi na abahlaseli bamanye amazwe. Umzimba emva koko udibanisa amandla amakhulu eeseli ezivuthayo ukulwa nabahlaseli ngokudala ukuphendula okanye ukudala izicubu ezibomvu ukukhusela ekusulelekeni.
I-LC neemeko Zesikhumba
Uphando olutsha lubonisa ukuba iLangerhans zeeseli ziyakwazi ukuchonga nokuhlasela iintsholongwane ezikusingqongileyo, oko kukuthintela usulelo. Oku kufumanisa ukuba ii-LC zibandakanyeka kwiimpendulo zokuzikhusela izifo ngezifo ezahlukahlukeneyo zingazenza zibe neethagethi zokufumana i- immunotherapy .
Oku kufunyanwe nakho kunako ukuguqula ngokubanzi ukuqonda kweendlela ezibangelwa izifo ezininzi ezinjengoku:
- I-Psoriasis : Imeko apho iiseli zelinen zakha kwaye zenza izikali ezihambisane nobomvu, ubuchopho kunye neengcambu ezinomileyo.
- I-Lupus : Isifo esibangeleyo senza ukuba i-immune system ihlasele izicubu zayo.
- Umhlaza wesikhumba : Ifomu eqhelekileyo yeCarcer e-US, ebonakala ngokukhula okungavamile kwamaseli esikhumba.
Kukho no kuphuhliswa kwezitofu eziphezulu ezilawulwe ngesikhumba (ukugonywa nge-epicutaneous) ejolise ekulayeleni i-LC ngqo ngqo kwesikhumba kunye nama-antigen. Uphando sele lujonge kwiigcini ezinikezwa ngesikhumba sokuphazamiseka kwengqungquthela ukuze kuvimbele ukukhula kwe- melanoma , uhlobo olunzulu lomhlaza wesikhumba.
Yintoni i-Langerhans Cell Histiocytosis (LCH)?
I-Langerhans cell cell i -titiocytosis (LCH) liqela lezinto ezingabonakaliyo, iingxaki ze-idiopathic ezingangonakalisa ulusu, amathambo kunye nezinye izitho.
I-loadload of cells efana ne-LC iveliswa kule ngxaki, nangona kunjalo, iiseli ze-LCH zibonisa ezahlukeneyo, i-hematopoietic (iiseli zegazi) kwimvelaphi yesifo.
Imithombo:
I-Langerhans P. Über yafa Nerven der menschlichen Haut. Iibhendi IArch [A] 1868; 44: 325-337.
Seo N., et al. Ukugonywa kwephepha le-peptide nge-permean peptide nge-corneum yokhuphaza-khungqakraza yesikhumba se-murin immunoprophylaxis. Proc Natl Acad Sci USA 2000; 97: 371-376.
Yagi H., et al . Ukuchithwa kwama-cytotoxic T i-lymphocytes echaphazelekayo ebantwini ngokugonywa kwephepha le-peptide. Kanti 2006; 66: 10136-10144.