I-Herpes Vaccine Development: IziPhambili kunye neNtuthuko

Ukukhangela isitofu sokukhusela kumlomo we-herpes yomlomo kunye ne- herpes yomzimba yinto ende. Abaphandi baye bazama ukufumana iintsholongwane ukususela nge-1930. Ngelishwa, akukho mpu melelo. Nangona iiglovu ze-herpes zenzelwe iigundane, izilingo zabantu azizange ziphumelele. Nangona ezinye izitofu ze-herpes ziye zabonakala zinezithembiso, ukuvavanywa okuninzi kunokuba kubonise ukuba kungcono kunokuba i-placebo.

Iigciwane zeHermes zeHerpes

Ukuthetha ngokusemthethweni, sele sele sele iigcini zamagciwane ezithintekayo kwiimarike. Nangona kunjalo, ngelixa ezi zitofu zikhusela kwiintsholongwane kwiintsapho ze-herpes, azikhuseli ngokumelene namagciwane omzimba okanye omlomo.

Ukugonywa kwe-shingles kunye nesitofu sokugonya inkukhu kubheka iindlela ezimbini zokugonywa kwe-herpes simplex. Inkukhu yokugonya inkukhu , okanye i-varicella zoster virus (VZV) yokugonya, inikezelwa ukukhusela abantu abatshatyalaliswa yiVZV. Ngokwahlukileyo, ugonyo lwe-shingles lunikezelwa ukunciphisa amathuba okuba intsholongwane ekhoyo iyakwenza kwakhona, kubangele i-shingles ephawulekayo.

Ezi zifana neentlobo ezimbini zokugonya eziye zacetyiswa ukukhusela kumlomo we-oral and genital herpes. Olunye uhlobo lokugonya luya kuba ngabantu abangazange banesifo, ukukhusela kwi-virus. Olunye uhlobo lwesigontsho luya kubantu ababenayo i-herpes , ukukhusela ekuchaseni.

I-Herpes Vaccine Priorities ukusuka kwiLizwe Lempilo Yehlabathi

Ngokwemfundiso, kunengqiqo yokuba isitofu sokugonya singasebenza ukukhusela i-herpes. Emva koko, kubantu abaninzi, i-immune system ilawula i-herpes infections ukuze bangaze babe nezibonakaliso . Oku kwenza ukuba intsholongwane ilungele kakuhle kwisigulane sokunyanga, nangona singenalo iinjongo ezifanelekileyo njenge-HPV .

Ngelishwa, iintsholongwane ze-herpes simplex ezibangela ukuba i-genital and oral herpes zibonakalise kunzima ukulawula ngeigciwane.

Ngo-2017, i-World Health Organisation (i-WHO) ichaze uluhlu lwezinto eziphambili ekuphuhliseni i-herpes vaccine. Ezi zinto ziphambili zibangelwa yinkomfa yabathathi-nxaxheba abavela kwihlabathi jikelele ukufumana ukuba zeziphi iimpawu zogonyamelo lwe-herpes eza kubaluleke kakhulu. Iqela lezinto eziphambili eziye zafika nazo:

Ngubani na ophakamisa ukuba iintlobo ezimbini zeigciwane zingasiluncedo kwizifo ezibangelwa i-herpes simplex. Izitofu zokugonya kweprophylactic, ezifana nesitofu senkukhu, ziza kunceda abantu ukuba bafumane i-herpes. Izigulane zonyango, njengegciwane lesigontsho, ziya kunciphisa inani lokugqashuka.

I-Herpes Vaccine Research

Kukho izilingo ezithembisayo zegciwane le-herpes. Nangona kunjalo, ukuya kutsho, akukho zilingo zomntu eziye zabonisa ukuphumelela ngokwaneleyo ukuzisa i-herpes vaccine. Oku kuthethi, kukho ithemba lokuphuhliswa kokugonya. Izazinzulu ziye zakwazi ukukhusela ezinye iinqunjana zabantu malunga nokutheleleka kwe-herpes. Ngaphezu koko, ekuqaleni kuka-2018, kwakukho ubuncinane abane vaccins ezine-HSV ezaphuhliswayo.

Ngelishwa, kukho iingxaki ezininzi ezenzululwazi ekufuneka zijamelane nazo xa ziphuhlisa i-herpes vaccine. Isibambiso esikhulu kukuba akukho mzekelo wezilwanyana ezintle apho uvavanyo lwezitofu.

Nangona iigundane kunye neengqimba zeginea zingasenwasulelwa yi-herpes, izifo zabo zintsholongwane zihluke kakhulu kwizifo ze-herpes. Oku kuthetha ukuba izitofu ezibonise isithembiso kwizilwanyana azizange ziphumelele ngokukodwa kubantu.

Izitofu zokugoma ze-Herpes nazo zinzima ukufunda ngezizathu ezininzi ezifanelekileyo. Kufuneka uvavanye abantu abaninzi ukuba babone ukuba basebenza. Abo bantu banokuba nzima ukufumana. Ukongezelela, ekubeni abaninzi abantu abanalo iimpawu ze-herpes, awukwazi ukulinda nje ukuba ubone ukuba abantu baqhambuka. Ufanele uvavanye ukuze ubone ukuba ngaba sele benesifo sengculaza. Okanye, ngenxa yezigulane zonyango, kufuneka uvavanye indlela isitofu sokugonywa sisithintela ngayo inani legciwane elichanekileyo . Ukujongana naluphi na le miba kunokwenza izilingo zokugonya ziphule kwaye zibiza.

Ikamva le-Herpes Vaccine Research

Ehlabathini lonke, oogqirha kunye nososayensi bayazi ukuba ukuyeka i-herpes kubaluleke kakhulu. Nangona abaninzi abantu abanesifo sengculaza abanalo iimpawu, i-herpes ingaba negalelo elikhulu ebomini babantu. Oku kunjalo ngokwenene kubantu abasuleleka xa bekhulelwe okanye bahlala kwiindawo ezininzi ze-HIV.

Yingakho uphando lwe-herpes lubaluleke kakhulu. Abantu baqhubeka bejonga iindlela ezintsha zokukhusela i-herpes infections kunye nokunciphisa ukuqhuma. Elinye iqela lophando, umzekelo, usebenzisa ama-lasers njengenxalenye yenkqubo yabo yokugoma. Injongo yabo kukukhuthaza ukuphuhliswa kwamaseli omzimba kumacandelo ekhumba. Kodwa, akukho zimpendulo ezikhawulezayo. Ngethamsanqa, kukho ezinye iindlela zokunciphisa umngcipheko wokudluliselwa kwe-herpes. Bobabini unyango olukhuselekileyo kunye nokwenene ngokuzikhusela ngokwesondo olukhuselekileyo lunokunceda ukukhusela abantu xa amaqabane abo esini esasetyholwe yi-HSV.

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> Gottlieb SL, Giersing BK, Hickling J, Jones R, Deal C, Kaslow DC; Iqela leeNgcaciso zeCandelo loVavanyo lweHSV. Ingxelo yomhlangano: Ukubonisana kweNkulumbano yezeMpilo kwiHlabathi kwi-herpes simplex virus (HSV) impawu ezikhethiweyo zemveliso, ngoMashi 2017. Ngo-2017 u-7. I-pii: S0264-410X (17) 31492-5.

> Lopes PP, Todorov G, Pham TT, Nesburn AB, Bahraoui E, I-BenMohamed L. I-Laser Adjuvant-Assisted Pisttide Vaccine ikhuthaza ukukhutshwa kwee-Dendritic iiseli kunye nokuphucula i-CD8 (+) T (EM) kunye ne-T (RM) I-Herpes Infection and Disease (‡). J Utywala. 2018 Februwari 7. pii: JVI.02156-17.

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