Isikhokelo soMonde kwiMveliso kunye neempembelelo ezingasemva kwe-Topical Fluorouracil
Unyango oluqhelekileyo lwe- basal cell carcinoma- uhlobo oluqhelekileyo lomhlaza wesikhumba emhlabeni jikelele-luyi-topical (olusetyenziswa kwilusu kuphela) ukhilimu, njengo-Efudex (i-fluorouracil). Ukuba ugqirha wakho ubeke u-Efudex, le ntshayelelo iya kukunika ingcaciso ngolwazi olufunekayo ukuyisebenzisa ngokufanelekileyo nangokukhuselekileyo.
Qaphela ukuba olu lwazi lungafihla zonke iinkqubo zokulondoloza, ukusebenzisana okanye iziphumo ezimbi ezi zibizo. Ukuba unayo nayiphi na imibuzo malunga naluphina isilwanyana othabathayo, qi
Sibanzi
U-Efudex (amanye amagama egunyaziso aquka iCarac neFluoroplex) i-cream cream esetyenziselwa unyango lwe -basal cell carcinoma xa iindlela eziqhelekileyo zingenakwenzeka, njengokuba kukho izilonda ezininzi okanye indawo ezinzima zonyango ebusweni okanye kwesikhumba. Isetyenziselwa ukuphatha i- actinic keratosis (ebizwa nangokuthi i-solar keratosis), leyo ingakhokelela kwisifo esichukumisayo se-squamous cell carcinoma xa sishiywa singaphathiswa.
U-Efudex uyisistim ye-chemotherapy ("i-antimetabolite") ephazamisa ukubunjwa kwe-DNA kunye ne-RNA, efunekayo ukuze ukwahlukana kweseli kunye nokukhula. Olu khuselo lubangela ukufa kweeseli ezinomdlavuza ngokukhawuleza, ezithatha ngaphezulu i-fluorouracil kuneeseli ezinempilo. Kwifom yeyoyiyo enamandla kakhulu, iFluorouracil isetyenziselwa ukuphatha isifuba, isisu, isilonda, kunye nesifo somhlaza .
Impumelelo
Impumelelo yezinga lokuphatha i- basal cell carcinoma nge-fluorouracil i malunga nama-93 ekhulwini, ngokusekelwe kuphando lwe-113 izilonda kwizigulane ezingama-54.
Nangona kunjalo, i-basal cell carcinomas, i-basal cells carcinomas, kufuneka ilashwe ngokuhlinzwa ngenxa yokuphumelela ngezilonda ezinjalo malunga nama-100 ekhulwini. Ngokungafani nokuhlinzwa, u-Efudex akakwazi ukushiya amacwecwe okanye ukukhupha ngokusisigxina imifanekiso yesikhumba.
Ezinye izifundo ngoku zijonge indlela i-Efudex kancinci eyenziwa ngayo kwiindawo ezingekho ebusweni zomzimba, kwaye indlela i-fluorouracil efanelana ngayo ne- imiquimod (Aldara) ukhilimu kunye ne- cryosurgery .
Ngokomzekelo, kwisifundo esisodwa saseJamani sezigulane nge- actinic keratosis , unyango lwe-imiquimod lubangele ukucocwa ngcono kwezilonda kunye neziphumo ezingcono zezilumkiso ezifaniswa ne-cryosurgery kunye ne-fluorouracil. Thetha ugqirha wakho malunga naluphi unyango olungcono kuwe.
Ukusetyenziswa
Kwi-basal cell carcinoma, kucetyiswa ukuba ama-5 ekhulwini ama-fluorouracil ukhilimu afakwe maxesha amabini ngosuku ngemali eyaneleyo yokufihla izilonda ubuncinane ubuncinane kwiiveki ezi-3 ukuya kwe-6. Unyango lunokufuneka ukuba lube lude nje kwiiveki ezi-10 ukuya kwi-12 ngaphambi kokuba izilonda zinyamalale, nangona kunjalo. Ukufaka isicelo saleliyeza, sebenzisa i-applicator-tipped-applicator, okanye sebenzisa iiglavu xa usebenzisa isicelo sakho. Ukuba isetyenzisiwe ngomunwe ongenakukhuseleka, kubalulekile ukuhlamba izandla kakuhle emva kokufaka isicelo saleliyeza. Gwema ukwenza isicelo kwamehlo, impumlo, okanye umlomo.
Imiphumela
Ngokuqhelekileyo, indawo eziphathwayo zingabonakali ngexesha lonyango, kwaye ngokuqhelekileyo iiveki ezimbalwa emva kokupheliswa kweyeza. Umphumo we-fluorouracil uvela kwizigaba ezine:
- Isigaba sokuqala sokuvuvukala: Ngethuba leveki yokuqala yesicelo, ukuvuvukala kancinci kwenzeka.
- Isigaba sokuvuvukala: Ngeeveki ezilandelayo, kubomvu nokuvuvukala kwenzeka nge-crusting and burning.
- Isisu sokuxhatshazwa kwesigaba: Izilonda zixazulula njengoko ulusu lukhupha.
- Isigaba sokuphilisa: Iiveki ezi-1 ukuya kweyesi-2, isikhumba esitsha sikhula kwindawo yonyango.
Iziphumo ezisecaleni eziqhelekileyo azidingi ukunakekelwa ngonyango (xela ugqirha okanye ugqirha lwenkonzo yezempilo xa ziqhubeka okanye zixhala) ziquka:
- isikhumba esibomvu okanye esibomvu
- Ukuguguleka komzimba (ukulahlekelwa kwinqanaba elingaphezulu kwesikhumba)
- Iliso lomsindo olubandakanya ukutsha, ukuvuthwa, ukuqonda, ukugubha, okanye ukunisela
- ukwandisa ubukhulu besikhumba elangeni kunye nokukhanya kwe-ultraviolet
- intlungu kunye nokutshisa indawo echaphazelekayo
- owomileyo, ukunyuka okanye ukuvuvukala kwendawo echaphazelekayo
- ukukhwabanisa isikhumba, ukutshaya kwendawo echaphazelekayo
- bubele
Iziphumo ezibi kakhulu ezifanele ukuxela ugqirha wakho okanye uqeqesho lwezempilo ngokukhawuleza kubandakanya:
- intlungu zesisu
- isifo sohudo
- ukuhlanza
- umkhuhlane
- bhinqa
Izilumkiso kunye nokusebenzisana
I-efudex ukhilimu ayifanele isetyenziswe ngabasetyhini abakhulelweyo, becinga ukukhulelwa, okanye ukunonophala kuba kungalimaza umntwana. Kwakungafanele kusetyenziswe ukuba unayo i-dihydropyridine dehydrogenase (DPD) ye-enzyme ukusilela, kuba iziphumo ezibi kakhulu zingabangela. I-DPD yimeko ezuzekayo ekhoyo kwipesenti ezi-3 ukuya kuma-5 ekhulwini lwabemi kwaye ifuna uvavanyo oluthile lokuhlola ufuzo. Ukongeza, xelela ugqirha ukuba:
- bafumana unyango lwamayeza
- ngaphambili bebenomdla ongavamile okanye owenzela ukuphefumula ukuya kwi-fluorouracil, enye i-chemotherapy, amanye amayeza, ukutya, idayi, okanye i-conservative
Gwema ukukhanya kwelanga kangangoko kunokwenzeka xa usebenzisa u-Efudex kuba kunokunyusa iziphumo zecala. Ukuba ubonwe ilanga, gqoba ingxowa kwaye usebenzise i-sunscreen. Njengamaxesha onke, kugwema ukukhusela iindawo zokucoca , eziye zaxhamla ngokucacileyo kwi-squamous cell carcinoma kunye ne-melanoma.
Imithombo
- "ICarac Ukuchazela Ulwazi." sanofi- aventis US LLC.
- "UEfudex Ukuchaza Iinkcukacha." Valeant Pharmaceuticals.
- Krawtchenko N, uRoewert-Huber J, Ulrich M, Mann I, Sterry W, Stockfleth E. "Ukufunda ngokuthe ngqo kwimibuzo ye-5% ye-imiquimod kunye ne-5-fluorouracil kunye ne-cryosurgery kwizigulane ezingenakuxhamla nge-actinic keratoses: ukuthelekiswa kweekliniki kunye iziphumo ze-hertological eziquka ukulandelelwa kwe-1-year. " Br J Dermatol . 157 I-Suppl 2: 34-40.
- INewman MD, Weinberg JM. Ulwaphulo lweengongoma ekwenzeni unyango lwe-actinic keratosis kunye ne-basal cell carcinoma. Cutis . 79 (4 I-Suppl): 18-28.