I-Taxotere yeCarstate Cancer - Xa isebenza kunye njani na?
I-Taxotere (docetaxel) isebenza njani kunye nexesha lini kunyango lomhlaza wesibeletho ?
I-Taxotere (i-Docetaxel) isebenza njani?
I-Taxotere (docetaxel) isebenza ngokufanayo kwiimithi ezininzi ze-chemotherapy ngokuphazamisa ukwahlukana kweseli (okubizwa ngokuba yi-mitosis). Ekubeni iiseli zomhlaza zizinye zeeseli ezihlukana ngokukhawuleza emzimbeni, ezi iiseli zithinteka ngokukhethekileyo ngenyathelo le-Taxotere kwaye, ngenxa yoko, ziya kufa kumazinga aphezulu xa isilwanyana senziwa.
Ukongeza kumdlavuza wesibeletho, i-Taxotere ingasetyenziselwa abantu abaneentlobo zemiphunga yomhlaza wamaphaphu, umdlavuza webele, okanye umdlavuza we-ovari.
Imbali - I-Taxotere yeHrostone-Resistant Advanced Prostate Cancer
I-Taxotere yaziswa kwi-anti-cancer prostate emva kokuqhutyelwa kuphando kwi- New England Journal of Medicine ngo-2004 ebonisa ukuba i-Taxotere ngokudibanisa ne-steroid prednisone yabangela ukuphucula ukuphucula xa kuqhathaniswa nesicatshulwa esisisigxina se-prostate cancer , mitoxantrone. I- New England Journal ibonisa kwakhona ukuba abo bantu baphathwa nge-Taxotere babenomgangatho obhetele wobomi kunye nokulawulwa kobuhlungu obuphuculweyo. Ngelo xesha, i-Taxotere ithathwa njengonyango olukhethiweyo lomhlaza wesifo se-prostate kumadoda aphethwe ngumhlaza wesifo somhlaza ongaphantsi kweprotate kunye ne-anti- hormone .
I-Taxotere isabonwa njengento efanelekileyo (kunye namanye amayeza afundiswayo) ukusetyenziswa kumadoda anomhlaza womhlaza wesifo se-prostate oye waxhathisa unyango lwe-hormone (unyango lwe-androgen unyango.)
I-Now-Taxotere ye-Early Hormone-Sensitive Canast Metastatic Cancer
Izifundo ezinkulu ezifana nesilingo se-CHAARTED phakathi kwabanye ziye zatshintsha indlela eya kumdlavuza we-prostmatic early-hormone-prostate for many men. Ezi khansa ziyakwazi ukufumana i-metastatic ngexesha lokuxilongwa okanye zibe yimetastatic emva kokuba unyango lokuqala lwe-prostate cancer .
Nangona uphathwe lwe-Taxotere lwalusetyenziswe ngaphambili kubantu ababenomdlavuza ophezulu we-prostate oye waxhathisa unyango lwe-hormonal, kubonakala ukuba usebenzisa unyango lwe-Taxotere kusasa-ngexesha elinye xa unyango lwe-hormone lwenziwa ukusinda kunye nokuphila ngokubanzi. Ngokuqinisekileyo, i-Taxotere ineempembelelo zesigxina njengoko kukho nayiphi na imichiza ye-chemotherapy, kodwa oku, kunye nokuqhubela phambili kusetyenziswa amanye amayeza, kuyimpawu enomdla yenkqubela phambili kunyango lomhlaza wesibeletho.
I-Taxotere yeCarcer Prostate Cancer
I-STAMPEDE Trial amadoda aqeshwe kunye nomdlavuza weprotate. Amadoda anikwe i-Taxotere ngexesha lotyando lwe-hormone laqalwa lafunyanwa libe neengxaki zokuphila ezingenasifo kunye nokuphila ngokubanzi kunabo baphathwa ngonyango lwama-hormone kuphela. I-caveat yinto yokuba amadoda awona mathuba angcono kakhulu kulolu unyango yibo "abane-high volume volume" yomhlaza wesibeletho.
I-Adjuvant Treatment ye-Cancellate Prostate Cancer
Kubantu abanesifo seprotate esisekuhlaleni abasengozini enkulu, basebenzisa i-Taxotere kwisimiso esilungileyo (ukuba "imeko") itholakala ukuba iyancipha kakhulu iziganeko zentsholongwane ezikude (isasaza) somhlaza wesibeletho.
La madoda athathwe nge-Taxotere kunye neyonyango ye-hormone kunye neyeza zonyango , kunokuba unyango lwe-hormonal kunye neyeza zonyango kuphela. Kakade, i-Taxotere inezinye iziphumo ezibi ezimele ziqwalaselwe.
Ziziphi iimpembelelo eziphambili
Njengazo zonke iziyobisi zonyango, kukho imiphumo eyahlukileyo eya kwenzeka xa uthatha i-Taxotere. Unokuba uqhelana nezinye zazo njengoko ziqhelekileyo kunye neentlobo ezininzi ze-chemotherapy. Iziphumo ezilandelayo zecala zenzeka ngaphezu kweyesithathu zabantu basebenzisa i-Taxotere:
- I-Neutropenia - Inani elisezantsi legazi lamhlophe elingasetyenziselwa isifo.
- I-Anemia - Inani elincinci le-cell red elibomvu elingazibangela ukukhathala phakathi kwezinye iimpawu.
- Ukulahleka kweenwele
- Ukugcinwa kwamanzi
- Uhudo
- I-Nausea - Esi sibonakaliso sisoloko silawulwa kakuhle kunye neyeza ezikhoyo zokulwa neengxaki zokusasazela isicupunu
- Ukukhawuleza
- Izilonda zomlomo
- Utshintsho lwe-fingernail
- Indlela yokuphendula ngayo - Oku kuqhelekileyo, kwaye imithi yokulwa neempawu ezikhuselekileyo idlalwa kunye ne-infusion.
Imithombo:
Fizal, K., Jenkins, C., no-I. Tannock. Ngaba i-docetaxel ingaba yinyaniso yokunyamekela izigulane ezineemitha zomhlaza zesifo se-prostate? Pro kunye nokuphambana. Amanqaku e-Oncology . 2015. 26 (8): 160-7.
I-Goodman, A. I-Docetaxel idibaniswe neThymone Treaty Yandisa Ukongiwa kwiCatter Cancer Advanced. I-ASCO Post . http://www.ascopost.com/issues/may-25,-2015/docetaxel-combined-with-hormone-therapy-extends-survival-in-advanced-prostate-cancer.aspx.
UJames, N., uSydes, M., Clarke, N. et al. Ukongezwa kwe-docetaxel, i-zoledronic acid, okanye zombini kwi-line-long-term hormone yonyango kwi-cancer yeprotate (STAMPEDE): iziphumo zokusinda kwi-adaptive, multiarm, i-multistage, isilingo esilawulwa ngokungahleliwe. Lancet . 2015 Dec 21. (Epub ngaphambi kokuprinta).
UMartel CL, uGumerlock PH, Meyers FJ, et al. Amanqanaba akhoyo ekulawuleni umdlavuza we-hormone refractory prostate. I-Cancer Phatha uMhla. 2003; 29: 171-187.
National Cancer Institute. Ucwaningo oluxhaswa ngemali lwe-NIH lubonisa ukunyuka kwindoda kumdlavuza we-prostatic cancer ofumana i-chemotherapy xa uqala unyango lwe-hormone. http://www.cancer.gov/news-events/press-releases/2013/E3805.
Tannock IF, de Wit R, Berry WR, et al. I-Docetaxel kunye ne-prednisone okanye i-mitoxantrone kunye ne-prednisone yesifo somhlaza wesifo seprotate. N. Engl. J. Med. 351 (15): 1502-12.