Ukukhathala ngenye yeempawu eziqhelekileyo ze- Multiple Sclerosis (MS) , kwaye inokuba yingozi kakhulu kwaye imithwalo-ngamanye amaxesha ngaphezu kweempawu ze-MS, njengobuthakathaka obunzima okanye ubunzima beengxaki.
Ukongezelela kokukhubaza, ukukhathala okuhlobene ne-MS kukubonakalisa uphawu oluqatha ukunyanga. Nangona i-Provigil (i-modafinil) ne-Symmetrel (i-amantadine) iqheleke ngokukhathala kwi-MS ukukhathala, akukho ubungqina obuninzi besayensi bokubuyisela ukusetyenziswa kwazo.
Kwakhona, la mayeza anemiphumo engathandekiyo. Ngokomzekelo, i-Provigil (modafinil) ingabangela ubundlobongela, obunokubangela ukhathala komntu. Cinga ukuba uphakamise ubusuku bonke-oku kuya kuqhubela phambili, kungekhona uncedo, ukudinwa kwakho.
Ngako-ke iingcali ezininzi ze-MS (kunye nabantu abahlala ne-MS) zifuna ngokukhawuleza isisombululo sokulwa nokukhathala kwe-MS. Nangona iimeko zokuphila ezifana nokuzilolonga zibonise isithembiso, baninzi bafuna "ipilisi yokulinda."
Coenzyme Q10
I-Coenzyme Q10 , eyaziwa nangokuthi yiCoQ10, i-antioxidant etholakala phantse yonke iseli emzimbeni wakho. Njengoko i-antioxidant, ayinakucala i-radicals yamahhala, eyonakalisa iiseli emzimbeni wakho. Ngokulwela i-radicals yamahhala, i-coenzyme Q10 ikholelwa ukuba igcina iiseli ziphilile, ziphucula ukusebenza kwazo kunye nombane we-metabolism.
I-Coenzyme Q10 nayo ikholelwa ukuba inezakhiwo ezichasayo. Oku kuthetha ukuba kunokuhlaziya umzimba womntu, esiyazi ukuba uphelelekile kumntu onomsebenzi we-MS.
Enyanisweni, uphando luye lwabonisa ukuba ukongezwa nge coenzyme Q10 kunciphisa amanqaku athile avuzayo, njenge- tumor necrosis factor (TNF) , egazini.
Ngako, ngaba uncedo olufana ne-coenzyme Q10 lunceda wakho okanye umkhathala wakho onxulumene ne-MS? Kungakufaneleka ukuzama, ngokutsho kwesinye isifundo. Oko kuthethwa, qiniseka ukuba uxoxe naluphi na umrhumo omtsha okanye amayeza kunye nogqirha wakho kuqala ukuqinisekisa ukuba ukhuselekile kwaye kukulungele.
Ukunyangwa kwe-MS Ukukhathala nge Coenzyme Q10
Ngo-2016 isifundo kwiNutrition ye-Neuroscience, abathathi-nxaxheba abangama-45 abane-multiple sclerosis babenomsebenzi wokufumana i-500mg ye-coenzyme Q10 okanye ipilisi ye-placebo yonke iiveki ezili-12. Isifundo sasiyimpumputhe kabini, esithetha ukuba abathathi-nxaxheba okanye abaphenyi abazi ukuba ngubani ofumene i-coenzyme Q10 ngokumalunga nowafumana ipilisi ye-placebo.
Ekuqaleni kweso sifundo, isiqhelo esasetyenziswa ngokubanzi ukulinganisa ukukhathala kwi-MS (ebizwa ngokuba yi-Scatigue Scouriness Scale) salawulwa kubo bonke abathathi-nxaxheba. Kwaye kwaphinda ilawulwe kwakhona ekupheleni kwesifundo (kwiiveki ezili-12).
Inkcazo yoButhathaka obunzima (FSS) iqulethe iingxelo ezi-9 ezifunyenwe kwinqanaba le-seven-point, enye inentsingiselo "ayivumelani nxamnye" kwaye isisixhenxe sichaza "sivuma kakhulu." Amanqaku amanqaku aphakathi kwamanani anesithoba, aphezulu amanqaku abonisa ukukhathala okukhulu.
Umzekelo womzekelo ovela kwinqanaba "ukukhathala kukuphazamisa umsebenzi wam, intsapho, okanye ubomi bentlalo." Ukuba uthe wavuma ngokucacileyo nale nkcazo, uya kubaleka amanqaku angama-7 (amanqaku aphezulu).
Iziphumo zophando zafumanisa ukuba abathathi-nxaxheba abathatha i-coenzyme Q10 banomlinganiselo ophantsi kwi-FSS score-oku kuthetha ukukhathala okungaphantsi-xa kuthelekiswa nabathathi-nxaxheba abathatha ipilisi ye-placebo.
Ukunyanga iimpawu ezixakekayo kwi-MS neCoenzyme Q10
Kwisifundo esifanayo, bonke abathathi-nxaxheba baphinde bahlolwa ngeempawu zokudakumba ngokusebenzisa i-Beck Depression Inventory (BDI).
I-BDI iqukethe imibuzo engamashumi amabini anesibini ekhethwe ngamanani amanqaku athatyathwa nganye kwizinga ukusuka kwi-zero ukuya kwiintathu, kunye neyesithathu ezimele iimpawu ezinzima kakhulu. Imizekelo yeempawu ezixinzelelekileyo ezihlolwe kulo mvavanyo ziquka:
- iimvakalelo, ukuphelelwa ithemba, ukudideka, ityala, kunye / okanye ukucaphuka
- iimpawu zomzimba ezifana nokulahleka kwesisindo, ukhathala, ukulahlekelwa ngumdla kwisini, nokulahlekelwa ngumdla
- iingcinga zokuzibulala
Ekupheleni kweso sifundo, abathathi-nxaxheba abathatha i-coenzyme Q10 babenokuphucuka okukhulu kwiimpawu zabo ezixinzeleleyo, xa kuthelekiswa nabathathi-nxaxheba abathatha ipilisi ye-placebo.
Injongo yeziphumo zoFundo
Iziphumo zibonisa ukuba i-coenzyme Q10 inenzuzo ekunciphiseni ukukhathala kunye neempawu ezidityanisiweyo kubathathi-nxaxheba be-MS. Le ngcamango enomdla, ngakumbi ukususela ekubeni i-coenzyme Q10 iyatholakala kwi-counter-counter.
Kwakhona iphrofayili yempembelelo ephantsi, eneempembelelo eziqhelekileyo ezibandakanya:
- esiswini
- isicaphulelo
- isifo sohudo
- ukukhawuleza
- intloko
I-Coenzyme Q10 iyafumaneka nakwiindidi zeefomulations eziquka iifomflethi ezincinci kunye neengqungquthela, iipilisi, kunye ne-spray yomlomo.
Oku kuthethwa konke, isifundo sasincinci (abathathi-nxaxheba abangama-45 kuphela) kwaye sahlala iiveki ezili-12. Izifundo ezinkulu kunye nexesha elide lihlola umphumo we-coenzyme Q10 kubantu abane-MS kufuneka kwenziwe.
Kwakhona kubalulekile ukuqonda ukuba iCoenzyme Q10 ayivunywanga yi-US Food and Drug Administration (FDA) yokunyanga naziphi na izifo zonyango, kuquka ukukhathala kwi-MS.
Funa Isikhokelo Esivela KuDokotela Wakho
Nangona i-coenzyme Q10 yongezelela kwaye ifumaneka ngaphandle komyalelo, kufuneka ithathwe kuphela phantsi kweliso lugqirha, ingakumbi kuba kungenakulungele wonke umntu.
Ngokomzekelo, kwabanye abantu, i-coenzyme Q10 inganciphisa iswekile yegazi. Oku kunokuba yingxaki kubantu abanesifo sikashukela abathatha amayeza anesigxina sezantsi leswekile.
Ingakwazi ukusebenzisana namanye amayeza njengemishanguzo yegazi okanye imishanguzo yegazi. Ngoko nangona ugqirha wakho kukunika ilungele ukuzama i-coenzyme Q10, unokufuna ukubeka iliso olulodwa.
Kwakhona, i-dosage esetyenziswe kule sifundo iphakame ngokukhawuleza kwi-500mg ngosuku. Uninzi lweebhotile zongezelelo zithi zingathathi ngaphezu kwama-200mg ngosuku. Ukuba uya kuzama oku kuncedisa, qinisa umthamo ochanekileyo nodokotela wakho. Ngokomzekelo, ukuthatha umthamo ophantsi kakhulu kungaphantsi kweyonyango (ngamanye amagama, unganikeli ithuba lokuncedisa).
I-Peek kwiKamva yeCoenzyme Q10 kwi-Multiple Sclerosis
I-Coenzyme Q10 ayizange ihlolwe kakhulu kwi-sclerosis ezininzi, kodwa oku kungatshintsha.
Enyanisweni, uphando oluxhaswa yiNational Institute of Neurological Disorders kunye neStroke lihlola imiphumo yebizo elibizwa ngokuthi i-Idebenon-isilwanyana esenziwe ngabantu esifana ne-coenzyme Q10. Uphononongo luhlola ukhuseleko kunye nokusebenza kwe-Idebenone ekuphatheni abantu abane -MS .
Uphononongo lubonisa ngokuthe ngantoni izinga lokuqhubela phambili kwe-atrophy yengqondo (ukwehla kweengqondo ukusuka ekulahlekelweni kwamaseli enyongqangi) kubantu abathatha i-Idebenone ngokumalunga nabantu abathatha indawo ye-placebo.
Olu pho nonongo luyiSigaba se-I / II, ngokunjalo kakhulu, kodwa kusenomdla-ikakhulukazi kuba ngoku akukho mishanguzo evunyiweyo ye-FDA yokunyanga i-MS ephambili.
ILizwi
Nangona uphando olungakumbi lwezenzululwazi lufuneka luyenze ukhuseleko kunye nenzuzo yokuthatha i-coenzyme Q10 ekuphatheni iimpawu ze-MS njengokhathala, okanye eso sifo ngokwaso, esi sifundo se-2016 kwiNyululwazi yeNutrition iyisiqalo esihle.
> Imithombo:
> Mezawa M et al. Ifom ye-coenzyme Q10 iyancitshiswe iphucula ukulawulwa kwe-glycemic kwizigulane ezine-type 2 zeswekile. Biofactors . Ngo-2012 uNgo-Dec; 38 (6): 416-21.
> Sanoobar M, Dehghan P, Khalili M, Azimi A, Seifar F. Coenzyme Q10 njengonyango lokhathala kunye nokudakumba kwezigulane ezininzi ze-sclerosis. Neutry Neutrals . 2016; 19 (3): 138-43.
> Sanoobar M et al. Ukuxhaswa kweCoenzyme Q10 kuphakamisa amanqaku atshabayo kwizigulane ezine-multiple sclerosis: i-blind blind double, i-placebo, ilawulwa yilingo lonyango elingaqhelekanga. Neutry Neutrals. 2015 NgoMeyi; 18 (4): 169-76.
> IYunivesithi yaseMary Medical Centre. (NgoJanuwari 2015). Coenzyme Q10.
> IiNational Institutes of Health. (Oktobha 2016). I-Blind Double Blind Placebo-Controlled Phase I / II Trial Clinical Trial of Idebenone kwizigulane ezinePrayimari Multiple Sclerosis (IPPoMS).