I-HMGB2 Ngaba iyahambelana nokuguga kunye ne-Cartilage Degeneration
Isizathu seCartilage Degeneration
Abaphandi baye bazama ixesha elide ukufumanisa ukuba yintoni eyenza i- cartilage de degeneration ehambelana ne- osteoarthritis . Uphuhliso lwezenzululwazi lubonisa ukulahlekelwa kwiprotheyini ethile ukusuka kwinqanaba le-cartilage ngamalungu. Le protheni, ebizwa ngokuba yi-HMGB2, ibonakala idlala indima ebalulekileyo ekufeni kwe-cartilage.
Nantsi into eyenzekayo kwiCartilage Degeneration
I-cartilage ye-Articular yiyona nto inzima kodwa isisitye esilulayo esithatha amathambo ngaphakathi kwendibano, evumela ukunyakaza.
I-cartilage ikhiqizwa kwaye igcinwa ngamaseli e-chondrocytes, kwaye iquka i-collagen ene-fibrous kunye nama-proteoglycan.
I-Osteoarthritis iqala xa kukho ukuphazanyiswa kwinqanaba lomhlaba we-cartilage - kwakhona libhekiswa njengendawo engabonakaliyo. Ubungqimba bomhlaba lubaluleke kakhulu kwizinto ezine ze-cartilage ngokubambisana, ngokuhambelana ngokuhambelana ngokufanelekileyo. Amalungu aqhelekileyo anendawo engqamlekileyo yomqolo ovumela amajoyina ukuba adibene. I-cartilage iphinda iqinise amanxeba kwaye ithatha amandla. Xa ububanzi bomhlaba buqala ukuhlakala, kunjalo, i-osteoarthritis iqala ukuphuhlisa kwaye inkqubo engenakuphikiswa iyaqaliswa ekugqibeleni itshabalalise umqolo we-cartilage kuze kube sekupheleni kwesigaba-sithuba: ithambo lixubha kwithambo edibeneyo.
Abaphandi bayazi ukuba isigaba sokuqala se-osteoarthritis sasinxulumene nokungonakaliswa kwe-cartilage kwindawo engaphezulu. Yintoni abaphandi abayazi ngayo kukuba nangaphambi kokutshatyalaliswa kobuninzi bomhlaba, kukho ukulahlekelwa kwiprotheni ebophayo ye-DNA, i-HMGB2.
Okunye malunga ne-HMGB2 kunye nendima yayo kwi-Health Cartilage
Kwinqanaba lomhlaba we-cartilage kumalungu, i-HMGB2 isekela ukusinda kwe-chondrocyte. I-Chondrocytes ziphela iiseli ezitholakala kwi-cartilage - zivelisa i-cartilage. Ukubeka nje, ukulahleka kwe-HMGB2 kudibaniswa nokuguga kunye ne-chondrocytes ezinokuncitshiswa okanye zokupheliswa kwinqanaba le-cartilage.
Ukuba i-HMGB2 iyona nto iphambili ye-chondrocytes enempilo, ibonisa indlela yokuphucula unyango olutsha ukugcina i-cartilage nokukhusela ukubola kwayo.
Yiyiphi ukuPhuculo okubhekiselele kwikamva
Yintoni ebalulekileyo yokufumana? Kwavela kubambiswano phakathi kwabaphandi abavela kwi-Scripps Research Institute eLa Jolla, eCalifornia; IYunivesithi yeSan Raffaele eMilan, eItali; kunye neYunivesithi yaseKogoshima eJapan.
Iindlela ezinokuthi zenze uphando ngexesha elizayo ziyakwazi ukuhamba ngeendlela ezimbini. Bakwazi ukujonga iamolekyuli eziya kumisa ukulahlekelwa yi-HMGB2 kwaye ziphuhlise zibe ngamachiza enyango. Baya kukhangela iindlela zokuvuselela ukuveliswa kwe-HMGB2, ngakumbi kubantu abaye bafumana ukulahleka kwe-cartilage, ukulungisa i-cartilage. I-Osteoarthritis iyakucingelwa ngelinye ilanga ukuba inokuthi ithintelwe okanye ikhutshwe. Ukufunyanwa kwendima ye-HMGB2 kwi-osteoarthritis inokuchaphazela nendlela amangqamuzana asetshenzisiweyo asetshenziselwa ukuhlaziywa kwezicubu kwixesha elizayo.
Kungenzeka ukuba i-HMGB2 yincinci nje encinane yomfanekiso we-cartilage degeneration. Uphando luvame ukuvelisa inkcazelo ebangel 'umdla ekugqibeleni iphelelwe ngumntu. Kungenakukwazi ukufumana iziyobisi ezichaphazela i-HMGB2 ngendlela efunekayo yokulungisa nokwakha i-cartilage. Kodwa inqaku ngalinye elitsha kunye nezonxibelelwano ezintsha kwikhonkco zingakhokelela kwinkqubela ekukhuseleni nasekunyangeni kwe-osteoarthritis.
Umthombo:
Ukulahleka okuhlobene nokuguga kweprotheni ye-chromatin i-HMGB2 kwi-cartilage ye-articular ixhunywe kumlinganiselo weselula kunye ne-osteoarthritis. Tanaguchi N et al. PNAS.