Ixesha elide le-Steroid Usetyenzise njani i-Bones, kunye ne-Steroid-Induced Osteoporosis
Ukuba unesifo sokugulisa isiguli (IBD) , ugqirha wakho unokumisela i-steroids njenge- prednisone ukunciphisa ukuvuvukala ngexesha lokutshatyalaliswa. Iziphumo eziqhelekileyo ze-steroids ziqala ukucaphukisa, kodwa ininzi yazo iya kuhamba xa i-dosage ifakwe phantsi kwaye iyanqanyulwa.
Nangona kunjalo, i-steroids inokuthi igalelo ekuphuhliseni imiphumo enzulu kwaye ingasigxina, ingakumbi xa ithatyathwa kumayeza aphezulu okanye ixesha elide.
Enye yale miqathango i-osteoporosis eyenziwa yi-steroid. Kuyaziwa ukuba i-steroids inokufaka isandla ekulahlekeni kwethambo. Kulabo bathatha i-steroids, ukucela ugqirha malunga ne-osteoporosis kunye nokuvavanywa ngezikhathi zibalulekile izinto ezinokukunceda ukubamba ukulahleka kwethambo kwangoko.
Yintoni i-Osteoporosis?
I-osteoporosis yintlupheko yamathambo, nto leyo ebangela ukuba baphulukane nokuxinwa kwabo kwaye babe brittle kwaye banokuthi bangakwazi ukuphuka. Ngokuyininzi becinga nje njengesifo se-women-post-menopausal, okwenyaniso kwinqanaba, kodwa kunokwenzeka kumadoda okanye kwabesetyhini banoma yiphi na ubudala abasengozini. Ezinye zezinto ezinobungozi zibandakanya:
- Ubudala (ngaphezu kwama-65)
- Ukuba ngumntu waseCaucasian okanye waseAsia
- Imbali yentsapho ye-osteoporosis
- Ukwakha okuncinci / okuncinci (ngaphantsi kwe-154 lbs)
- Ukuphulwa kwangaphambili
- Ukusetyenziswa kwamachiza athile (kuquka i-steroids kunye nama-hormone e-thyroid)
- Ukuqeda umva kwangaphambili
- Isidlo esaneleyo se-calcium; ukungena kwivitham
- Ukutya okuphezulu kwiprotheni
- Indlela yokuphila
- Ukutshaya
- Ukusetyenziswa kakubi kotywala
- Isifo sePathyathy
I-Steroid-Yenza i-Osteoporosis
Ngelixa i-steroids yenza ukunciphisa, iyancipha kwakhona ukwakheka kwethambo elitsha, ukwandisa ukuphuka kwethambo elidala, nokunciphisa ukuchithwa kwe-calcium ekudleni ngumzimba. Kwimeko ye-IBD, ukuphuhliswa kwe-osteoporosis inokuqulunqwa ngumlinganiselo osele we-calcium owenziwe ngumzimba.
Ukuxilongwa kweSteroid-Induced Osteoporosis
I-osteoporosis ifunyaniswa novavanyo olubizwa ngokuba ngama-x-ray absorptiometry (DEXA). I-DEXA inokukhathazeka kunokuba i-x-ray rhoqo kwaye inokufumana ukulahleka kwethambo kumazinga ayo okuqala. Akukho buhlungu kwaye kuthatha malunga nemizuzu eyi-10 ukugqiba.
I-American College yeRheumatology icebisa uvavanyo lwe-DEXA ekuqaleni kwonyango lwe-steroid kunye nexesha (mhlawumbi ngonyaka) emva koko xa unyango luqhubeka.
I-osteoporosis iqheleke ngakumbi kubantu abanesifo sikaCrohn kunezo ezine-ulcerative colitis, ngoko i-DEXA isiseko sokubamba ukulahlekelwa kwethambo kwangoko kunconywa kwizigulane ze-Crohn zezifo.
I-DEXA icetyiswa kuphela kwizigulane ezine-ulcerative colitis ezichazwe nge-steroids njengonyango olude.
Ukukhusela iSteroid-Induced Osteoporosis
I-taper steroids. Ukuthintela ukulahleka kwethambo kwangaphambili, i-steroids imele isetyenziswe kuphela kwisilinganiso esona siphezulu kakhulu sexesha elifutshane. Ukwelashwa kwe-Steroid kunokuba luncedo kakhulu kwiimeko ezininzi ezivuthayo, kodwa iinzuzo kufuneka zilinganiswe ngokumalunga nemiphumo emibi efana ne-osteoporosis. Musa ukulungelelanisa yakho imithi phambi kokuba uthethe nodokotela wakho.
Yeka ukutshaya. Ukubhema i-cigarettes kudibaniswa nezinto ezininzi zokuphila ezichaphazela ekulahlekelweni kwethambo, njengokutya okubi kunye nokungabikho kokuzivocavoca.
Abasetyhini abavuthayo banokuvelisa i- estrogen encinci kunye nokuvalelwa kwexesha lokuhamba komntu kwangaphambi kwabesetyhini abangabambi. Ukongeza, ababhemayo bathatha ixesha elide ukuze baphilise kwiintlobo, kwaye ukusetyenziswa kwecuba kubonakala kunciphisa ukuxinwa kwethambo.
Ukuzivocavoca. Ukunyamezela ukunyameka, njengokuxhatshazwa komzimba, kunceda ekunyuseni ubukhulu beethambo. Ukuzivocavoca kukukhuthaza ukudala ubukhulu besithambo kunye nokugcinwa kwe-calcium.
Ukunyanga iSteroid-Induced Osteoporosis
Izibonelelo. Ngenxa yokuba i-calcium ixutywe emathunjini amancinci, i-malabsorption iyenzeka ikakhulu kubantu abanesifo sikaCrohn abavuthayo emathunjini amancinci . Abantu abane-ulcerative colitis, ebonakalisa emathunjini amakhulu , banokuba ne-calcium engcono.
Ukongezwa kwe-calcium kwisantya se-1500 mg ngosuku kunokucetyiswa ukuba uphathe okanye uthintele ukulahleka kwethambo. Ugqirha wakho uya kufuneka akucebise malunga nokuba yeyiphi i-dosage, ukuba kukho na, ifanelekile.
Kubalulekile ukwazi ukuba i-calcium ayisebenzisi yedwa-idinga i- vitamin D ukuze ixutywe ngumzimba. I-Vitamin D ihlanganiswa xa isikhumba sibhekene nelanga, kodwa abaninzi abantu abachithi ixesha elaneleyo lokwenza i-vitamin D. ngokwaneleyo. I-calcium, i-vitamin D ayifumananga kakuhle ngabantu abavuthayo emathunjini amancinci abangelwa yi-Crohn's disease. Ukuxhaswa kwansuku zonke kunye ne-400 IU ye-vitamin D kunokucetyiswa ukulwa nokulahlekelwa kwethambo lokuqala; kwakhona, thetha nogqirha wakho malunga nento ecebisiweyo kuwe.
I-Bisphosphonates: i- Fosamax (i-alendronate), i-Actonel (i-risedronate), i-Didronel (i-etidronate), i-Boniva (ibandronate), kunye ne-Reclast (zoledronic acid) yi- bisphosphonates ezisetyenziselwa ukunceda ukuphulwa kwethambo nokugcina ubunzima beethambo. La mayeza anokwandisa ukwanda kweethambo emgodini kunye nomlenze.
I-Bisphosphonates okwangoku kuphela yiklasi yeziyobisi ezivunyelwe yi-FDA ukunyanga i-osteoporosis kumadoda. Zinikezwa nge calcium kunye ne vithamini D.
Forteo (Teriparatide). I-Forteo yi-hormone ye-parathyroid evunyelwe ukunyanga i-osteoporosis; ingasetyenziselwa ukufikelela kwiminyaka emi-2. Abantu abaye bafumana unyango lwe-radiation, njengomdlavuza, ababaviwa abafanelekileyo kulo mziza. I-Forteo ilawulwa imihla ngemihla ngejoza.
ICalciton (Calcimar, Cibacalcin, Miacalcin). I-Calcitonin inceda ukunciphisa ukulahlekelwa kwethambo kunye nokuthintela i-fractures emgodini kodwa kungekhona kwintambo. La mayeza alawulwa njengesipopu esiswini kwaye angabangela ukucaphukiswa kwiindinyana zomntu. Akunakwenzeka ekuphatheni i-osteoporosis eyenziwa yi-steroid, ngoko ke i-calcitonin isetyenziswe kuphela kwizigulane ezingenakuzithatha okanye ezingenakuxhomekeka kwonyango ngama-bisphosphonates.
Imithombo:
Amin S. "I-Glucocorticoid-Yenza i-Osteoporosis." Ikholeji yaseMerika yeRheumatology 2010.
Rosen HN. "Ukuthintela unyango lwe-glucocorticoid-induced osteoporosis." Ngomhla wama-Meyi 2010.