I-Estrogen yi-hormone enkulu eyenziwa ngama-ovaries kunye nancinci ngama-adrenal glands, kwaye ixanduva lokuphuhlisa impawu zesini zesini. I-Estrogen iyadingeka ekuphuculweni kakuhle kwezitho zesini, ukuzaliswa kwenkqubo yamathambo, ukulawulwa komjikelezo wesini kunye nokugcinwa kokukhulelwa.
Ngexesha lomjikelezo wesini, i-estrogen ifihliwe yi-follicle yeqanda ekhulayo kunye neencedisi ekuqiniseni i-endometrium yokunyuka nokukhulelwa.
Kananjalo enye yezona ihommoni ezinkulu zokukhulelwa, i-estrogen isekela ukuveliswa kobutyebi kumzila wokuzala okhuthaza ukwanda kwesidoda ngokunciphisa iminyango yomlomo wesibeleko. Ukufikelela ekupheleni kokukhulelwa, i-estrogen ikhuthaza ukukhula kwamanqayi ebisi ngaphakathi kwamabele kwaye kuphucula umphumo weprolactin (ihommoni enkulu ejongene nokukhwabanisa kwintombi).
Synthetic Estrogen
I-Estrogen yimi hormone ephezulu efumaneka kwipilisi yokulawula ukuzalwa . Iipilisi nganye zihluke, ziqulethe i-estrogen kunye / okanye i- progesterone .
Njengoko ibhinqa elide kwaye lingene ekupheleni kwexesha lokumisa, amazinga e-estrogen aqala ukuhla. Ngenxa yoko, abanye oogqirha banokwenza i-estrogen yonyango yokuguqula indawo, ukunciphisa ezinye zeempawu.
I-Estrogen Inkokheli kuBasetyhini ne-PCOS
I-PCOS yona nto ibangelwa yintsholongwane ye-ovulatory kwaye ikholelwa ukuba ubukhosi be-estrogen, yinxalenye yesizathu.
Ukungabikho kwe-ovulation kukhokelela kumazinga aphezulu e-estrogen kunye neprogesterone enganeleyo. Ukungaxhaswanga ngu-progesterone, ukutyhila kwe-estrogen rhoqo kunokubangela ukuba i-endometrium ibe yomelele kakhulu, enokubangela ukuba kuphapheke okunzima kunye / okanye okungaqhelekanga ukuphuma kwamanzi.
Kwiminyaka emininzi, umdlavuza we-endometrial ungabangelwa ngenxa yokuvuselela okuqhubekayo ngamanqanaba aphezulu e-estrogen engaphazamiseki yi-progesterone, okwenza ukuba i-uterine ibhalelwe kwaye ingaphumeleli kakuhle.
Ukuqhaqha okukhulu kweMithini kunye nePCOS
Kwabesetyhini abane- menorrhagia (ixesha elide okanye ixesha elinzima), ukulawulwa kwe-estrogen kunokucetyiswa ukuba umise okwesikhashana ukuphaphaza nokuzinzisa i-endometrial lining. Ngenye indlela, i-progesin ingenziwa ilawulwa ngomlomo ukuzama ukufezekisa isiqendu esilawulwayo. Iipilisi zomlomo ezingaphantsi komlomo okanye izixhobo zangaphakathi (iUD) ezifana ne-Mirena (inkqubo ye-levonorgestrel-yokukhupha i-intrauterine system) nazo zinokukhetha ukunciphisa ukuphuma kwegazi. Kwezinye iimeko, i-endometrial ablation, inqubo yokucocwa ekhupha ininzi ye-endometrial lining, inconywa.
Iingxaki zeNdalo ze-Estrogen Dominance
Nangona amanqanaba e-estrojeni aphezulu kunye nokungabi nalutho lweprogesterone yinto ebalulekileyo ekugqibeleni i-estrogen kubonina abane-PCOS, izinto ezinokusingqongileyo zinokudlala indima. Iikhemikhali kwindawo yethu, eyaziwa ngokuba yi- xenoestrogens , inokulinganisa i-estrogen ngokwemvelo emizimbeni yethu kwaye isebenze njengabaphazamisi be-endocrine.
Ezinye izinto eziphazamisayo ze-endocrine ziquka i-pesticides, i-Bisphenol A (BPA) kunye ne-phthalates (ezitholakala kwizikhonkwane zaseplastiki, iibhotile zamanzi kunye neeriti zamaphepha), kunye nama-parabens (amaninzi atholakala kwimveliso yokunakekelwa kwesikhumba kunye neenwele).
Kucingelwa ukuba i-BPA iphazamisa indlela yokubonisa, mhlawumbi ngokuphazamisa i-estrogen receptors. Amazinga e-BPA aboniswe kwizifundo ukuba ziphakame kwabasetyhini abane-PCOS.
Ukunciphisa ukukhutshwa kwakho kokuphazamiseka kwendalo, landela ezi ngcebiso:
- Khetha izitya zeglasi ukutshisa nokugcina ukutya
- Phuza iziyobisi kwiibhotile zeglasi okanye abo "BPA-free"
- Thenga iimpahla ezikhutshwe ngeempahla eziphawulwe "I-BPA-ezamahala"
- Yidla izinto eziphilayo kunye "nokutya kwama-hormone"
- Geza izandla kakuhle emva kokuphatha iirisithi zamaphepha
- Hlola izithako kwimveliso yonyango kunye neenwele, ukuthenga "ngaphandle kweparaben" endaweni yoko
- Ukongezelela, ukutya ukutya okunotye kwi- antioxidants kunokukunceda ukukhusela i-estrogen receptors evela kumonakalo ongqongileyo.
Ehlelwe ngu Angela Grassi, MS, RDN
Imithombo
Ukuhlanjululwa kwezibeleko ezingavumelekanga: Isikhokelo sabathinteli. Umbutho waseMerika woLwazi lweZityalo ozalisekileyo ofikelele kwiJuni 8, 2015 http://www.reproductivefacts.org/BOOKLET_abnormal_uterine_bleeding/
Barrett ES1, iSobolewski M2. I-Polycystic ye-ovary syndrome: ngaba iikhemikhali eziphazamisa iikhemikhali zidlala indima? Semin Reprod Med. 2014 ngoMeyi; 32 (3): 166-76.