Ngaba le Nqamle-I-Cruciferous-Compostable Compound Inganceda Ukulwa neCarcer?
I-Diindolylmethane yinto engokwemvelo eyenziwa xa umzimba uphula i-indole-3-carbinol, i-compound efunyenwe kwimifuno e-cruciferous efana ne-broccoli ne-kale. Ifumaneka kwifomu yokongeza, i-diindolylmethane kuthiwa inika uluhlu lwezibonelelo zezempilo.
Kutheni Abantu Bithatha
I-Diindolylmethane icelwa ukuba ivelise utshintsho kwi-estrogen metabolism, inkqubo ye-biological icinga ukuba ithintela uphuhliso lwee-cancer ezixhomekeke kwi-hormone njengengculaza yesifuba.
Abacebisi bathi ukudla i-diindolylmethane kunokukunceda ukwandisa ukhuselo lwakho kwiintlobo ezininzi zomhlaza, kunye nokukhuthaza ukuxothwa kwegazi kunye nokulahlekelwa kwesisindo.
Izinzuzo
Kuza kube ngoku, uphando ngemiphumo yempilo ye-diindolylmethane ayinakulinganiswa. Kuphando lokuqala, ezinye izazinzulu ziye zafumanisa ukuba i-diindolylmethane inokuchaphazela umzimba we-estrogen.
Nangona kucingelwa ukuba ukuguqula i-estrogen metabolism kunokunceda ukukhusela kumagciwane athile axhomekeke kwi-hormone (njengomdlavuza wesifuba), akakho okwaneleyo uphando ukuqinisekisa ukuba i-diindolylmethane inokunceda ekukhuseleni umdlavuza.
Nanku ukukhangela kwezinye iziphumo eziphambili ezivela kwizifundo ezikhoyo:
1) Umhlaza webele
Nangona ezinye iingcali zelabhoratri zibonisa ukuba i-diindolylmethane inokunceda ukukhusela ukukhula kweeseli zomhlaza zesifuba, kukho izifundo ezimbalwa zekliniki.
Kwiphononongo elincinane le-2004 elipapashwe kwiZondlo kunye neCancer , abaphandi bafumene ukuba ukuthatha i-diindolylmethane izongezo kubangele utshintsho kwi-estrogen metabolism.
Uhlolisiso lwabandakanya abafazi abane-post-menopausal abanomdla weengcambu zesifuba.
Uphononongo luka-2015 olupapashwe kwi- Cancer Family uhlolisise ukusetyenziswa kwe-300 mg ngosuku lwe-diindolylmethane kwiinekota ezine ukuya kweyesithandathu kubafazi abalishumi elinesihlanu abane-BRCA1. Umlinganiselo we-urro estrogen (i-biomarker engahambelani ngokuphathelele ekuphuculeni umdlavuza webele) ayizange iguqulwe kakhulu emva kokuxhaswa.
2) ICercer Cancer
Nangona ezinye iinkcukacha zicebise ukuba ukuthatha izithako zedilolmethane kunokunciphisa ukuphuhliswa komhlaza wesibeleko, uphando olwenziwe ngo-2012 kwiBritish Journal of Cancer aluphumelelanga ukubonisa nayiphi na inzuzo. Uhlolisiso lwabandakanya amabhinqa angama-551 anesifo esingaqhelekanga, esingaphantsi kwee-cell. Kwiinyanga ezintandathu, abathathi-nxaxheba bathatha i-diindolylmethane okanye i-placebo yansuku zonke. I-Diindolylmethane izongezo zahluleka ukufumana impembelelo ebalulekileyo kwiintsholongwane zeseli yomlomo okanye nokuba khona kwe-HPV.
3) Ezinye iifom zeCanscer
Iziphumo zokuqala ezifunyenwe kwizifundo zethunge-vavanyo kunye nophando olususela kwizilwanyana lubonisa ukuba i-diindolylmethane inokukhusela umdlavuza wesibeletho , umdlavuza womhlaza, kunye nomhlaza wekolon . Nangona kunjalo, ngenxa yokungabikho kophando, kungekudala ukuxelela ukuba i-diindolylmethane inokukunceda ukulwa nale miba yomhlaza kubantu.
4) Ukulahlekelwa kwesisindo
Nangona i-diindolylmethane i-supplementation ngezinye izihlandlo iyancedwa njengezinto zokulahleka kwemithwalo yemvelo, akukho bungqina benzululwazi obuxhasa inkxaso yokuba ukuthatha i-diindolylmethane kukhuthaza ukulahleka kwesisindo.
Imithombo
I-Diindolylmethane ikhiqizwa xa umzimba ugalela i-indole-3-carbinol, i-compound efunyenwe kwimifuno elandelayo:
- Ibrokholi
- I Brussel ihluma
- Ikhaphetshu
- Icauliflower
- Imifuno yeClarlard
- Kale
- Imifuno ye-Mustard
- Watercress
I-Diindolylmethane iphinda ifumaneke kwifom yokongeza, ithengiswe kwiivenkile zokutya zendalo kunye nezitolo ezijoliswe kwizongezelo zokutya.
Iimiphumo zangaphandle
Kuze kube namhlanje, kuncinci kakhulu kulwazi malunga nokukhuselwa kokusebenzisa i-diindolylmethane isongezelelo rhoqo okanye kwixesha elide.
Ngenxa yokwenza i-diindolylmethane inokuchaphazela i-estrogen metabolism, kukho ukukhathazeka ukuba ukuthatha i-diindolylmethane i-supplementary iyakwenza ukuba iimeko ze-hormone ezixhomekeke kwi-hormone (eziquka i-hormone-dependent cancer, endometriosis , kunye ne- uterine fibroids ).
Ngokombiko othile, omnye umfazi ophilileyo wachaza i -serous chorioretinopathy (iimeko ezibangelwa ukukhubazeka okubonakalayo) emva kokudla ngokugqithisileyo kwe-diindolylmethane kwiinyanga ezimbini.
Emva kokuyeka ukuxhaswa, iimpawu zakhe zazisombulula emva kweeveki ezisibhozo. Ukugqithisa isikhumba nge-eosinophilia (amazinga aphakanyisiweyo ama-eosinophil ngokuqhelekileyo ayenzeka ekuphenduleni uhlobo oluthile lokuphendula okanye ukusetyenziswa kweziyobisi) luchazwe emva kokusetyenziswa kwe-diindolylmethane. Iintlungu ezinamahloni kunye kunye kunye, ngokukodwa ezinqeni nasemadolweni, ziye zabikwa.
Ngenxa yokukhathazeka ngokhuseleko, kubalulekile ukufumana iingcebiso zezokwelapha ngaphambi kokusebenzisa i-diindolylmethane supplements. Abasetyhini abakhulelweyo okanye abahlengikazi akufanele bathathe i-diindolylmethane supplements. Kwakhona, abantu abaphathwa unyango kufuneka bangawuthathi.
Unokufumana iingcebiso ezongezelelweyo ekusebenziseni izongezo apha , kodwa kubalulekile ukuba uqaphele ukuba ukuzinyamezela ngesifo esingapheliyo nge-diindolylmethane kwaye ukuphepha okanye ukulibazisa ukunakekelwa okuqhelekileyo kunokuba nemiphumo emibi.
I-Takeaway
Ngenxa yokungabikho kwenkxaso yenzululwazi, kungekudala ukukhuthaza izilungiso ze-diindolylmethane njengonyango oluqhelekileyo kwanoma yimuphi umgangatho wezempilo.
Nangona kunjalo, ukwandisa izinga lakho le-diindolylmethane ngokubandakanya imifuno ye-cruciferous e-indole-3-carbinol ekudleni kwakho kunokunceda ukwandisa impilo yakho yonke. Imifuno yeCruciferous isityebi kwizinto ezininzi ezikhuthaza impilo, kubandakanya i-antioxidants.
Imithombo
I-Castañon A, i-Tristram A, i-Mesher D, ne-al. Umphumo wokuncediswa kwe-diindolylmethane kwi-low-grade-cytological abnormalities: i-double-blind, i-randomized, i-trial trial. Br J Cancer. 2012 Jan 3; 106 (1): 45-52. i-doi: 10.1038 / bjc.2011.496.
I-Dalessandri KM, i-Firestone GL, i-Fitch MD, i-Bradlow HL, iBjeldanes LF. Isifundo sokuqhubela phambili: umphumo we-3,3'-diindolylmethane isongezelelo kwi-urinary hormone metabolites kumabhinqa angama-postmenopausal anembali yesifo somhlaza wesifuba sokuqala. Cancer Cancer. 2004; 50 (2): 161-7.
Nikitina D, uLlacuachaqui M, Sepkovic D, et al. Impembelelo yomlomo we-3,3'-diindolylmethane ukuxhaswa kwi-2: 16A-OHE ratio kwi-BRCA1 zithinteli zokuthutha. Ngomhlaza weNtshonalanga. 2015 Juni; 14 (2): 281-6. i-doi: 10.1007 / s10689-015-9783-2.
USmith S, uSepkovic D, uBradlow HL, uAuborn KJ. 3.3'-I-Diindolylmethane kunye ne-genistein yehlisa imiphumo emibi ye-estrogen kwiLNCaP kunye ne-PC-3 yomhlaza wesifo somhlaza. J Nutriti. 2008 Dec; 138 (12): 2379-85.
Staub RE, Onisko B, Bjeldanes LF. Ukufa kwe-3,3'-diindolylmethane kwi-MCF-7 yesifo somhlaza wesifuba somntu. Chem Res Toxicol. 2006 Mar; 19 (3): 436-42.
Ukuziphendulela: Ulwazi oluqulethwe kule ndawo lujoliswe kwiinjongo zemfundo kuphela kwaye alithathi indawo yeengcebiso, ukuxilongwa okanye unyango ngumgqirha onelayisenisi. Akunakuthetha ukukhusela zonke iindlela zokulondoloza, ukusebenzisana kwezidakamizwa, iimeko kunye nemiphumo emibi. Kufuneka uncede unyango lwangonyango ngokukhawuleza kuyo nayiphi na imiba yempilo uze ubonane nodokotela wakho ngaphambi kokusebenzisa elinye iyeza okanye wenze utshintsho kwi-regimen yakho.