Izongezelelo ezi-3 ezinokunceda ukubuyisela ukusebenza kweeNgcini zeeNsimbi
Nangona i-current multiple sclerosis (MS) izifo eziguqula izifo zijolise ekunciphiseni ukuvutha kwengqondo kunye nomgudu womgogodla, abaphandi baphanda uphando olunokunceda ukulungisa into eyonakaliswe yonakaliswe kwi-MS-i-myelin sheath.
Ngokubuyiselwa kwesithintelo se-myelin , kukho ithemba lokuba umsebenzi wegazi lomntu ungabuyiselwa.
Okumangalisa ngakumbi kukuba ezi zikhulayo ze-myelin-ukubuyisela unyango ziyakongeza kwi-local shop yakho okanye i-pharmacy. Ezi zintathu zezi zondlo ziquka:
- Biotin
- Vitamin D
- I-Omega-3 fatty acids
Oku kuthetha, kubalulekile ukuqonda ukuba ukuhlolwa kwezi ncediso kunye nendima yabo e-MS kusekuqaleni kwaye kwenziwa ngokungaqiniseki.
Ukongezelela koko, ngelixa i-additives ingaba yongezwa ngokucacileyo (kungekhona enye indawo) kwiindlela zakho zokwelapha ze-MS zangoku, kubalulekile ukuba uthathe kuphela phantsi kolawulo lugqirha wakho.
Ukulumkela malunga nokusetyenziswa kokubaluleka kubalulekile kwizizathu ezininzi, kubandakanywa nokusetyenziswa kwesifo sotywala okanye ukuba ezinye izongezo, ezinjenge-omega-3 fatty acids, zinokuchaphazela ukuphumelela kwezilwanyana ze-MS okanye ezinye iziyeza ozithathayo.
I-Biotin e-Myelin Ukulungiswa kwi-MS
I-Biotin i-vitamin ebandakanyekayo kumbane we-metabolism kunye nokudala ama-acid acids emzimbeni.
Itholakala kwizondlo zokunyusa iinwele, isikhumba, kunye nokukhula kwesikhonkwane, kunye ne-multivitamines kunye nevithamini zokubeletha.
Ekubeni i-myelin isheath isicacco sokugcoba, abaphandi bacacisa ukuba ngokunika abantu iqondo eliphezulu (njenge-300mg ngosuku), i-myelin sheath inokubuyiselwa.
Ukongezelela ukubuyisela i-myelin (isiqhumiso esinqumlekileyo), ezinye izazinzulu zikholelwa ukuba i-biotin inokunciphisa ukubola kwe-axon ngokuphucula umbane.
Ukuchithwa kwe-axon kwenzeka ngokubanzi kwiintlobo ze-MS kwaye zibhekisela ekulahlekelweni kwemibindi yomnyo kwaye ekugqibeleni i-cell nerve death.
Umfanekiso omkhulu apha kukuba iingcali zicinga ukuba i-biotin ingasebenzisa umphumo wayo wokwelapha ngeendlela ezimbini-ibhonasi ebini. Nangona kunjalo, ubu bungqina bobunzululwazi obuxhasa indima ye-biotin ekunakekeleni i-MS inkulu kwaye ayifanelekanga.
Masiqwalasele ngokuthe kratya izifundo ezimbalwa ezibonisa ezi ziphumo ezixubekileyo.
Iingqimba eziya kwi-Biotin
Kwisifundo esincinane kwi- Multiple Sclerosis kunye neengxaki ezinxulumene nazo, abantu abangama-23 abane-MS eyimpumelelo okanye yesibini abaqhubela phambili banikezwa iqondo eliphezulu le-biotin, kwaye ukuphuculwa kuboniswe kwiimpawu ezahlukeneyo, ngokugqithiseleyo imbonakalo yembono, iingxaki zomgudu wokugcoba kunye nokukhathala.
Iziphumo ezixubileyo zeBiotin
Isifundo esikhulu kwi- Multiple Sclerosis sibonise ukuba i-do-high dose ye-biotin yaphucula ukukhubazeka okuhlobene ne-MS kwi-12 ekhulwini yabathathi-nxaxheba abane-MS. Nangona kunjalo, inyaniso yokuba iipesenti ezili-12 kuphela ezibonisa ukuphuculwa kubonisa ukuba mhlawumbi i-subset yabantu abane-MS banokuzuza ngokuthatha i-biotin.
Ukongezelela, kuphazamiseka ukuba abaphandi kulolu cwaningo baqaphele ukuba abo bathatha i-biotin babenezinye izinto ezintsha okanye bakwandisa izilonda zobuchopho kwii-MRIs zabo xa kuthelekiswa nezo ziko le-placebo.
Abaphenyi babuza ukuba i-biotin yayishukumisa impendulo yokuvuvukala (oku kungayi kuba kuhle).
Iingqimba phantsi kweBiotin
Isifundo sesithathu sikhathalela ngakumbi nge-biotin. Kulo pho nonongo, akukho phuculo lokukhubazeka oluhlobene ne-MS kubantu abane-MS. Enyanisweni, malunga nesithathu kwisithathu sabathathi-nxaxheba babenokwenyuka kwesifo sabo, ngokugqithiseleyo kunye nobuthakathaka bomlenze obuninzi, ukulinganisela okungaphezulu, kunye nokuwa okungaphezulu.
Kakade, ukunyuka kwesifo sabo kungahambelani ne-biotin kwaye ngenxa yokuqhubela phambili kwe-MS. Nangona kunjalo, abaphandi belo cwaningo baqiqa ukuba i-biotin ye-dose ephezulu inento yokwenza nayo.
Mhlawumbi, i-biotin yatshintshe isidingo somzimba esingafuni ukukhusela ingqondo kunye nomgudu womgudu, ukuvumela ukuba isimiso somzimba sokuzivikela sisiphumelele.
Indima yeVithamini D e-Myelin Repair
I-Vitamin D ifumaneka kwizibonelelo, kunye nokutya ezithile ezifana ne-salum, ioli ye-cod ye-food, ityhunti eneenqanawa, izikhuni zeqanda, kunye neengqolowa eziqingqiweyo, ubisi kunye nejusi le-orange.
Ngokusekelwe kwizifundo ezininzi, siyazi ukuba ukungabikho kwe-vitamin D kwandisa ithuba lomntu lokuphuhlisa i-MS . Nangona kunjalo, xa umntu ephethe i-MS, akucaci ukuba i-vitamin D ichaphazela njani umsebenzi wabo wesifo (njengokuthi i-vitamin D inokwanela ingakwandisa ithuba lomntu lokuba ne-MS kwakhona).
Nangona uphando lwe-vitamin D lujolise ngokukodwa kwizinto ezibangele okanye ezichaphazela i-MS, uphando lokuvula amehlo kwimiqulu ye-Cell Biology lukhanyisa inxaxheba yesithathu kwi-vitamin D kwi-MS-ukuba i-vitamin D ingabandakanywa ekulungiseni i-myelin.
Olu pho nonongo lufumene ukuba ii-vitamin D zokufumana iiprotheyini ezibizwa ngokuba yi-retinoid X receptor-gamma (RXR gamma receptor), okuyiprotheyini echaphazelekayo ekulawuleni ukukhula komzimba weetel ezivelisa i-myelin (ebizwa ngokuthi i-oligodendrocyte).
Abaphandi bafumanisa ukuba xa bongeza i-vitamin D ebuchosheni be-cell stem eziqulethe i-RXR ye-gamma receptor, inani le-oligodendrocytes ezibonisa i-myelin iprotheni eyisiseko (iprotheni eyona nto iphambili ye-myelin sheath) yanda ngama-80 ekhulwini.
Ngamanye amazwi, i-vitamin D yavuselela ukubuyiswa kwe-myelin-umdlalo omangalisayo. Ngokuqinisekileyo, oku kuhlolisiso olunye, kwaye ezininzi iimfuno kufuneka zenziwe ukuze kucaciswe oku kufumana. Konke kuzo, nangona kunjalo, olu pho nonongo lubonisa indima ebonakalayo yokusebenza kwe- vitamin D kwimpilo yakho ye-MS.
Indima ye-Omega-3 Fatty Acids e-Myelin Repair
I-Omega-3 fatty acids ifumaneka kumafutha "amahle" abizwa ngokuba ngamafutha e-polyunsaturated. Ezi fatshi ezilungileyo zikhoyo kwizinto ezifana noku:
- Iintlanzi ezinamafutha (umzekelo, i-salmon, i-mackerel, i-herring kunye ne-sardines)
- iimbwe zechai
- Iimbewu zeflax
- IiSoybe
- IWalnuts
- I-oyile yecanola
I-oil oil supplements iqulethe i-omega-3 fatty acids.
Ubungqina benzululwazi obuxhasa ukuxhamla ukutya okucebile kwi-omega-3 fatty acids ekuphatheni i-MS ixutywe. Ngamanye amagama, kukho idatha echanekileyo ebonisa ukuba inciphisa i-MS iphinda ibuyele okanye iphucise ukuqhubela phambili kokukhubazeka kwe-MS.
Oko kwatshoyo, kunomdla ukuqaphela ukuba uphando lwezilwanyana zamva nje luye lwabonisa ukuba i-omega-3 fatty acids inokukhuthaza ukuvuselelwa. Nangona kunjalo, (kwaye yilapho kukho ukudideka khona), ukuba i-omega-3 fatty acids inceda ukubuyisela i-myelin, ngoko ukuphuculwa kokukhubazeka kwizifundo zangaphambili zezigulane ezine-MS kufuneka kubonwe. Oku kungahambelani kuye kwabashiya abaphandi ukuba bahlalutye iintloko zabo.
Konke kuzo, mhlawumbi ukuba inxaxheba ye-omega-3 yokusetyenziswa kwi-MS inzima, kwaye inzuzo yayo inokufumaneka kwezinye izinto ezinxulumene nazo. Mhlawumbi, ukufumana i-omega-3 ngokwemvelo ngokuchasene nokuxhaswa kukuchaphazela iziphumo, okanye mhlawumbi, abanye abantu abafumani i-omega-3 kunye nabanye.
Ngaphezu koko, i-omega-3 fatty acids ingaphulwa zibe zimbini, i-eicosapentaenoic acid (EPA) kunye ne-docosahexaenoic acid (iDHA). Kungenzeka ukuba umlinganiselo weendlela ezi zinto zenziwa ngayo unokuchaphazela iziphumo zophando.
Umgca wokugqibela kukuba kwenziwe uphando olungakumbi ukutyhila iingenelo ezinyanisekileyo (ukuba kunjalo) ze-omega-3 fatty acids ekuphatheni i-MS. Oku kuyinyani ngokukhethekileyo kubantu abane-MS eqhubekayo, njengoko izifundo ngoku zijoliswe kubantu abane-MS-reving-MS.
ILizwi
Kuyamangalisa ukucinga indlela esikude ngayo ekuqondeni okungcono kunye nokuphathwa kwe-MS. Ngokuphanda iindlela zokwelapha ezijongene ne-MS eziphelweni zombini (ukukhusela umonakalo we-myelin nokubuyisela i-myelin eye yonakalisiwe kakade), kukho ithemba lokwenene ekupheleni kwesi sifo.
Ukuba unayo i-MS (okanye uthandekayo), qhubeka uhlala unomdla kwimpilo yakho yemihla ngemihla-uhlale unomdla kwi-MS yolwazi, qhubeka no-MS wakho unyango, ufikelele kwabanye ukuxhaswa, kwaye kubaluleke kakhulu ukuzonwabisa ngexesha elixabisekileyo lobomi.
> Imithombo:
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> de la Fuente AG et al. Ukubonakaliswa kwe-heterodimer ye-vitamin D ye-receptor-retinoid ilawula ukuhlukaniswa kweselluli se-oligodendrocyte. J Cell Biol. Ngo-2015 uMdluli-7; 211 (5): 975-85.
> Sedel F et al. Isisindo esiphakamileyo se-biotin kwisifo esingapheliyo sesifo se-sclerosis: isifundo somqhubi. Ukungqubuzana kweMult Scler Relation . Ngo-2015 uMar; 4 (2): 159-69.
> Torkildsen O et al. I-ω-3 yonyango ye-acety acid kwi-sclerosis ezininzi (i-OFAMS Study): ityala elilawulwe ngokungahleliyo, elimbini, elingaboniyo. Arch Neurol . Ngo-Agasti ka-2012; 69 (8): 1044-51.
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