Akuqhelekanga Ngeemeko ezivuthayo
Iiplateslet zincinci zechungechunge zeseli ezidlala indima ebalulekileyo kwi-hemostasis (inkqubo yokuyeka ukuphuma emva kokulimala). Abanalo nucleus kodwa baqulethe i-cytoplasm kunye neeprotheni ezibalulekileyo kumsebenzi weplatelet. Iiplatelet ziveliswa yi-megakaryocytes kwintolongo yethambo.
Iiplatelet zivame ukuphakanyiswa kwi- rheumatoid arthritis .
Imeko yeeplatelet eziphakamileyo zibizwa ngokuba yi-thrombocytosis.
Kwi-rheumatoid arthritis, amajoyina ayindawo eyona ndawo yonakalisa umonakalo. Yilapho ukuvuvukala kwendawo kwenzeka, kufaka phakathi iiseli zegazi ezibandakanya i-neutrophils kunye ne-macrophages. Ezi iiseli zikhuthaza ukuveliswa kweplatelet-activating factor, okubangela ukuba kuhlanganiswe iiplatelet zegazi, ukubenza bakwazi ukuthatha inxaxheba kwimpendulo evuthayo emzimbeni.
Iiplatelets kwi-Rheumatoid Arthritis
Abantu abaphilileyo banomlinganiselo weplatelet kwinqanaba eliqhelekileyo le-150,000-400,000 / mm3. Kwakudala ngowe-1972, kwaphawulwa kwincwadi yezobugcisa abaphandi bafumana ukubala kweplatelet ephezulu malunga neyesithathu kwisigulane se-rheumatoid arthritis.
Oku kwafunyaniswa kuhambelana ngqo nomsebenzi wesifo. Abaphandi baye bafumana ukulungelelaniswa phakathi kokubala kweplatelet ephakamileyo kunye ne- anemia , i-leukocytosis (inani elongeziweyo leeseli ezimhlophe zegazi), kunye ne- rheumatoid factor .
Kukho ubudlelwane obuphambene phakathi kwe-hemoglobin kunye nenani leplatelet, intsingiselo, xa i-hemoglobin iphantsi, inani leplatelet liphezulu. Umbutho we-sideropenia (ukungabikho kwesebe) kunye nokuphakama kwamanani eplatelet akufunyanwanga kubalulekile.
Abanye abantu abane-arthritis enobuchopho obukhulu kakhulu banokuba nezibalo ezingaphezu kwesigidi.
Xa isi sifo silawulwa ngamachiza, inani leplatelet libuyela ngokuqhelekileyo.
Iiplatelet ziphakanyisiwe kungekhona kuphela kwi-rheumatoid arthritis, kodwa nakwezinye izimo ezivuthayo ezifanayo. Ulungelelaniso oluphawulekayo lufunyenwe phakathi kweeplatelet eziphakamileyo kunye ne- vasculitis esinqunyiwe . Ezinye izibonakaliso ezingabonakaliyo ze-rheumatoid arthritis (oko kukuthi, ezichaphazela iinxalenye zomzimba ngaphaya kwamalungu nje) zifunyenwe ngokuphindaphindiweyo phakathi kwabantu abaphakanyisiweyo.
Izizathu
Ingcaciso ecacileyo yeplatelet ephakamileyo ebalwe kwi-rheumatoid arthritis ibonakala ihambelana nesifo semfuyo esingapheliyo, into eqhelekileyo yesifo se-rheumatoid arthritis. Ngokwe- Annals ye-Rheumatic Diseases , i-homeostasis eplatelet ilawulwa yi-thrombopoietin.
I-Thrombopoietin ngumlawuli oyintloko wokukhula kwe-megakaryocytes kunye nokwahlukana. Kucatshangelwa ukuba i-thrombopoietin inxulumene nekhemikhali kwi-erythropoietin (i-hormone echaphazelekayo kwi-cell cell production), ngokuyininzi ngenxa yezigulane ezingapheliyo kunye ne-reticulocytosis (inani elinyukayo lamaseli egazi obomvu) kwaye ukwandisa amazinga e-erythropoietin aphezulu kuneenombolo zeplatelet eziqhelekileyo. Ukuba amazinga e-erythropoietin anyuselwa kubantu abane-anemia ne-rheumatoid arthritis, izibalo eziphakamileyo zeplatelet zingabangela.
Enye inokwenzeka ukuba ngaba ukuveliswa kweplatelet okongeziweyo kubangelwe ukutshabalalisa iplatelets okanye ukusetyenziswa. Abaphandi baphakamise ukuba ukubalwa kweplatelet ephakamileyo kunokuxhunyezwa kwiimpendulo ze-immunological kwi-arthritis ye-rheumatoid-mhlawumbi ngenxa yeengxube ezincinci kwi- synovium engapheliyo.
Ngokutsho kweKley's Bookbook yeRheumatology , kukho izizathu ezintathu eziphambili zeeplatelet eziphakamileyo kwizifo ze-rheumatic:
- I-thrombocytosis esebenzayo, esecaleni kwenkqubo yokuvuvukala engapheliyo. Kwiimeko ezinjalo, i- cytokines (IL-1, IL-6, kunye ne-TNF) ingaba ngabalamli abasebenzayo kumgaqo wokuveliswa kweplatelet ngexesha lokuvuvukala.
- I-thrombocytosis yamaqabane ingenzeka ngenxa yokuguqulwa kwesigidi esinefa.
- I-clonal thrombocytosis (i- thrombocytosis ephambili okanye ebalulekileyo ye-thrombocytosis) yinto engavumelekanga yokuveliswa kweplatelet ngenxa yokunyuka kwe-megakaryocyte.
> Imithombo:
> Hutchinson RM et al. I-thrombocytosis kwi-rheumatoid arthritis . Iziganeko zeeRheumatic Diseases. (1976) 35: 138
> Kiraz S. et al. I-bloodstream thrombopoietin kwi-arthritis ye-rheumatoid ene-thrombocytosis, i-Rheumatology yeklinikhi. 2002 Nov; 21 (6): 453-6.
> Kelley's Bookbook yeRheumatology. INguqulelo yesithoba. Isahluko 17. Iiplatelet kunye neRheumatic Diseases. Amakhasi 249-251.
> I-Thrombocytes kwi-Rheumatoid Arthritis. I-Scandinavian Journal yeRheumatology. Selroos, O. 1972 1: 136.