Ubuncinane ama-10 ekhulwini kwabasetyhini ababeletha abantwana banamaPolycystic Ovary Syndrome (i- PCOS ), ingxaki ye-endocrine eneempembelelo zokuzala kunye neziphumo. Abafazi abane-PCOS banamathuba amanqanaba aphezulu e-insulin kwaye, ngenxa yoko, banomngcipheko okwandisiweyo weemeko ezinjenge-dyslipidemia (i-triglycerides ephezulu kunye namazinga aphantsi kwe-HDL), uhlobo lwesi-2 lwesifo sikashukela , kunye nesifo se-metabolic syndrome.
Ingaphezu kwesigamu sabasetyhini abane-PCOS baninzi kakhulu okanye baninzi kakhulu, kwaye baninzi ingxelo yokulwa nokunciphisa ubunzima naphezu kokutya okunempilo kunye ne-exercise regimen.
Nangona kunjalo, naphezu kobunzima bokulahlekelwa kwesisindo, izigulane nge-PCOS zidlalwa ukuba zinciphise umzimba kwaye i-PCOS yazo iya kuba ngcono. Nangona ukulahleka kwesisindo kunokuphucula ukuhamba kwimihla ngemihla kwaye kunciphise umngcipheko weemeko zokuxilisa, akuthethi ukuba i-PCOS iya kuhamba. Ngamanye amaxesha kugxininisa ukulahleka kwesisindo kugxininisa ukubaluleka kwempilo. Iintsingiselo, abafazi abane-PCOS bangenza utshintsho oluzinzileyo ekudleni kwabo kunye nendlela yokuphila yokuphucula impilo yabo nokuphucula ixabiso leeb lab. Oku kuya kwenzeka okanye ngaphandle kokulahleka kwesisindo.
Ngezantsi uluhlu lweemvavanyo eziqhelekileyo zegazi ezidla rhoqo ukubeka i-PCOS. Ezinye iziphumo zebhabhi kunye nemigqaliselo ingasetyenziselwa ukuxilonga ibhinqa nge-PCOS . Ukugcina i-PCOS ingabi ngakumbi kwaye iyanciphisa umngcipheko weemeko ezingapheliyo zexesha elide, abafazi abane-PCOS kufuneka bahlose ukugcina iimvavanyo zegazi kwiindawo eziqhelekileyo.
Ukuze uhlale phezulu kwimpilo yakho, gcina umkhondo weziphumo zakho zegazi uze uqhathanise utshintsho kunye novavanyo olutsha.
Insulin
Nangona i-insulin ingeyona inxalenye yeendlela zokuxilonga kwi-PCOS, ngamanye amaxesha ihlolwe ukuba ihlolwe i-PCOS kwaye ibone indlela umntu onqatshelwe ngayo i- insulin . Amanqanaba afanelekileyo okuzila ukutya kwe-insulin kufuneka abe phantsi kwe-10 mg / dl.
Amanqanaba aphezulu e-insulin ayimingcipheko yesifo seswekile. Ukuvavanya i-insulin yokuvavanya kunesichukumiso kwaye kuyona echanileyo xa kuqhutywe uphando oluqhutyelwe uphando. Ngaphandle kweso sifundo, ukuvavanya i-insulin yokuvavanya kuyathembeka kakhulu xa kwenziwa kunye novavanyo lomlomo lwe-glucose ukunyamezela, oluchanekileyo kwaye lucacile.
Iprotheni eSebenzayo
Xa kuthelekiswa nabasetyhini abangenawo i-PCOS, abafazi abanemeko babonisa amanqanaba aphezulu kumenzi weeprotheriya ovuzayo c-reactive (CRP). Izicwangciso ze-CRP ukuvuvukala emzimbeni. I-CRP ephakamileyo idibene nomngcipheko ophezulu we-coronary disease (CAD) kwabanye abantu. I-CRP ephezulu (i-hs-CRP) isetyenziswe ngokuchanekileyo. Amanqanaba e-hs-CRP ngaphantsi komnye ayabonwa njengezantsi, amanqanaba enye ukuya kwebathathu abhekwa njengento ephakamileyo ngokuphakamileyo, kwaye amanqanaba angaphezu kweesithathu aphakanyiswa njengophakamileyo.
Triglycerides
I-Triglycerides (TG) yindlela yokugcina igazi yeoli. Amanqanaba okuzila okufanelekileyo we-TG kufuneka abe phantsi kwe-150 mg / dL. Amanqanaba aphakamileyo abonisa ingozi eyongezelelekileyo yesifo senhliziyo. I-TG inokuphakanyiswa ngenxa yezidlo eziphezulu kwi-carbohydrates, ukungasebenzi, ukukhuluphala, kunye namazinga aphezulu e-insulin (ngokuqhelekileyo imeko kwi-PCOS). Ngaphandle kokutya okunempilo kunye nendlela yokuphila, i-TG iyancitshiswa nge-oil oil supplementation.
HDL
I-HDL, okanye "efanelekileyo," i-cholesterol, isusa i-cholesterol engaphezu kwegazi kwaye inokukunceda ukukhusela kwisifo senhliziyo. Izifundo zibonise ukuba amazinga aphantsi kwe-HDL ayimingcipheko yokuphuhlisa isifo senhliziyo. mg / dL. Amazinga aphantsi kwe-HDL aqhelekileyo kubasetyhini abane-PCOS. Amanqanaba aphantsi ale cholesterol angabangelwa ukungasebenzi, i-genetics, uxinzelelo, ukutshaya, ukunyuka kwe-triglycerides, kunye nokutya okubi .
IHemoglobin A1C
Uvavanyo lwe-hemoglobin A1c, olubizwa nangokuthiwa yi-A1c, lilingana nokulawulwa kwetyhukela egazini kwiinyanga ezimbini ezidlulileyo. Olu vavanyo lisetyenziselwa ukuxilonga isifo seswekile okanye isifo sikashukela kwaye ubone ukuba utshintsho kwimpilo yakho, ukutya, kunye neyeza okanye izondlo ezondlobisayo kunciphisa umngcipheko wakho wesifo sikashukela.
Izinga le-HA1c le-7 ekhulwini okanye ngaphezulu libonisa isifo sikashukela. Ukubekwa njenge-diabetes esandulela isifo seswekile, i-HA1c iphakathi kwama-5.7 ekhulwini kunye nama-7 ekhulwini.
Enzymes
Izilingo zomsebenzi wentsholongwane, okanye "i-LFTs", ziyi-enzyme zesibindi i-alanine aminotransferase (ALT) kunye ne-aspartate aminotransferase (AST) ephakanyisiwe xa isibindi sonakaliswe. Ezi zingasetyenziselwa ukuxilonga nokubeka esweni isifo sesibindi esingasinxilisayo (NAFLD). I-NAFLD ihamba ngeepesenti ezili-15 ukuya kuma-55 ekhulwini kwabasetyhini abane-PCOS, ngokuxhomekeka kwiinkqubo zokuxilonga ezisetyenziswayo. I-NAFLD ivela ngenxa ye-triglycerides engaphezulu (i-fat) egcinwe esibindi, ebangela ukulimala nokuvuvukala. Iindaba ezilungileyo kukuba isibindi esinamafutha sinokuguqulwa nokuguqulwa kwendlela yokuphila. Utshintsho ekudleni kwakho, umsebenzi kunye nezinye izongezo zokutya kunokuphucula izifo zesibindi.
AMH
I-Anti Mullerian Hormone (AMH) , iprotheyini ekhethekileyo ekhishwa ngamaseli afakelwe ukukhula kwe-folicula yeqanda inyanga nganye. Aman ama-AMH ahambelana nenani lezinto ezinobungqina be-antral ezitholakala kwi-ovary inyanga nganye; ukuphakama kwe-antral count count, iphakamileyo lama-AMH. Ngenxa yokuba abesifazana abane-PCOS banamanani amaninzi e-folral follicles, amazinga aphezulu ase-AMH adlalwa ngokufanayo. I-AMH isetyenziselwa njengendlela yokubonisa indawo yokugcina i-ovarian kwiimfazana ezindala.
Amanqanaba aqhelekileyo ama-AMH aphakathi kwe-0.7ng / ml ukuya ku-3.5ng / ml. Amanqanaba angaphantsi kwe-0.3ng / ml athatyathwa phantsi kwaye akhombise ukuba inani elincinci lamaqanda liphakathi kwe-ovari kwaye linciphisa ukuzala. Amanqanaba angaphezu kwama-5.0sng / ml aphakamileyo kwaye angabonisa i-PCOS.
Vitamin D
Ulwalamano oluphambeneyo lukhona kubasetyhini abane-PCOS abanamazinga aphantsi e-vitamin D kunye nomngcipheko ophezulu wemicimbi yezempilo. Ukuvavanya okanye isimo se-vitamin D kubalulekile kwimpilo enhle kunye nenhlalakahle. I-Endocrine Society itusa amanqanaba ubuncinane ubuncinane ngama-30 ng / ml, nangona ezinye iindibano, ezifana ne-Vitamin D Council, zibonisa ukuba ama-vitamin D amanqanaba kufuneka abe ngama-40 ng / ml.
IVithamini B12
Ukuba uthatha i- metformin, kufuneka ube namazinga akho e-vitamin B12 ahlolwe rhoqo ngonyaka njengoko i-metformin inokuchaphazela ukuxutywa kwe-vitamin ebalulekileyo. Amanqanaba afanelekileyo e-vitamin B12 kufuneka abe ngama-450 pg / mL okanye ngaphezulu. Ezinye iimvavanyo zegazi ezingasifumana isimo seB12 ziquka i-homocysteine kunye ne-methylmalonic acid. Ukuxhaswa nge-vitamin B12 ngoku kuyacetyiswa ukuba uthatha i-metformin.
> Imithombo:
Inkcazo yesithathu yeNkqubo yeMfundo yeSizwe ye-Cholesterol (NCEP) Iqela leNzululwazi ekuThekeni, kuVavanyo kunye nokuPhathwa kwe-Blood High Cholesterol kwi-Adult (PDF), ngoJulayi 2004, amaZiko eZiko lezeMpilo: iNational Heart, Lung and Blood Institute.
> Miller M, Stone NJ, i-Ballantyne C, et al. I-Triglycerides kunye nesifo se-cardiovascular: isitatimenti sesayensi esivela kwi-American Heart Association. Ukuhamba. 2011; 123: 2292-2333.
> IDumont A1, uRobin G2, i-Catteau-Jonard S3, i-Dewailly D4. > Indima > ye-Anti-Müllerian Hormone kwi-pathophysiology, > ukuxilongwa > kunye nokunyangwa kwePolycystic Ovary Syndrome: ukuhlaziywa.Reprod Biol Endocrinol. 2015 Dec 21; 13 (1): 137.
> Aroda VR, et al. Usetyenziso lweMetformin elide kunye neVithamini B12 Ukusilela kwiZiphumo zoPhulo lweSifo seSifo seSifo seSigu. Study.J Clin Endocrinol Metab. 2016.
> Jia XZ. Impembelelo ye-vitamin D kwimilinganiselo yekliniki kunye neyayimvelo ye-polycystic ovary syndrome abasetyhini: Uhlalutyo lwe-meta. J Obstet Gynaecol Res. 2015 Nov; 41 (11): 1791-802.
> Nadjarzadeh A. Impembelelo yenkxaso ye-omega-3 kwiprofayili ye-androgen kunye nesimo sokuya esikhathini kwabesetyhini abane-polycystic ovary syndrome: Iilingo lezonyango ezingaqhelekanga. Iran Ir Reprod Med. Ngo-Agasti wama-2013; 11 (8): 665-72.