I-Polycystic ovarian syndrome, okanye i- PCOS , yimeko apho amaqanda amabhinqa kunye neengqungquthela ze-adrenal zivelisa i-androgens ngaphezulu kunezinye eziqhelekileyo, ezibangele ukwanda kweenwele zomzimba, izigulane kunye nezikhathi ezingaqhelekanga.
Nangona abaphandi bengacacanga isizathu esicacileyo se-PCOS, kuyaziwa ukuba ukungalingani kwenkqubo ye-endocrine kuxanduva lweenguqu ezininzi ezinxulumene nazo.
Nangona kunjalo, akusaziwa ngokuqinisekileyo oko kubangela ukuba abo batshintshe.
Nantsi ukujonga kwiingcamango eziphambili ezikholelwa ukuba zingemva kwe-PCOS:
I-Hypothalamic-Pituitary-Ovarian Axis
IiHormone ziiprotheni eziveliswa ngumzimba ngaphakathi komzimba obangela utshintsho ngaphakathi kweseli okanye kwiqumrhu. I-Hypothalamic-Pituitary-Ovarian (HPO) i-axis yindlela yokulawula i-hormone ngaphakathi komzimba.
I-hypothalamus yintsimbi ngaphakathi kwengqondo, xa ivuselelwe, ivelisa ihomoni, eyaziwa njengeGonadotropin-Release Hormone okanye i-GnRH. I-GnRH iya kwi-pituitary gland, esinye isakhiwo esincinci kwingqondo. I-pituitary gland ivelisa iindidi zee-hormone ezilawula kunye nokugcina imisebenzi emzimbeni eminingi.
Kubaluleka kwi-PCOS, i-pituitary ivelisa i- FSH , okanye i-Follicle stimulating Hormone, ne- LH , okanye i-Lutenizing Hormone. UL uhamba kwi-ovary apho ivuselela imveliso ye- androgens .
Kuye kucatshulwa ukuba amanqanaba aphezulu angama-LH kunye ne-androgens, okuyi-testosterone, eyenza i-PCOS.
Nangona kunjalo, oku akuchazi ukuba kutheni abaninzi abafazi abane-PCOS abanalo amazinga aphezulu e-LH.
I-Insulin-Androgen Connection
Kuye kucatshangelwa ukuba i- insulin inendima ekuphuhlisweni kwe-PCOS. Ukongezelela ekulawuleni amazinga e-glucose, i-insulin ibangela isibindi ukuba sinciphise ukuveliswa kwe-molecule eyimfuneko ebizwa ngokuba yi-sex-hormone-binding globulin, okanye i-SHBG.
I-Testosterone ithathwa kwigazi yi-SHBG xa i-molecule ikhona. Ukuba inani elincinci le-SHBG lifumaneka, i-testosterone engaphezulu yamahhala (testosterone engathathwa yi-SHBG) igazini. Kukholelwa ukuba amazinga aphakamileyo e-insulin anokwandisa inani le-androgens eyenziwa yi-ovary.
Oku akuchazi ngokupheleleyo i-PCOS, njengabaninzi abasetyhini abane-PCOS abanalo ukunyanzelwa kwe-insulin , utshintsho kwindlela amangqamuzana omzimba asabela ngayo kwi-insulin, kunye nomba oqhelekileyo obonwayo kwi-PCOS.
Genetics
Enye into ebalulekileyo yi-PCOS yileyo ehamba kwiintsapho. Abasetyhini abane-PCOS kaninzi banalo udade, unina, umzala okanye umamakazi onayo imeko. Nangona oogqirha bengayazi isizathu esona sizathu, ngokucacileyo unesixhumanisi sokufa.
Abaphandi bemihla ngemihla bayasondela ekuboneni ukungaqhelekanga kwemfuyo enokuthi iphosakele. Oku kunzima ngenxa yokungabi naluvavanyo olulodwa lokuxilonga kunye nenxaxheba yokuba izinto zangaphandle (ezifana nokukhuluphala, ukutya kunye nokuzilolonga) zingadlala ekuphuhlisweni kwesi sifo.
Imithombo:
UHarris, uColette no-Carey, uAdam. I-PCOS: Isikhokelo sowesifazane ekujonganeni nePolycystic Ovary Syndrome .UHorson; ELondon. 2000.
Thatcher, uSamuweli. I-PCOS: I-Epidemic efihliweyo . Iimpembelelo zoLwazi; Indianopolis. 2000.
Prapas N, Karkanaki A, Prapas I, Kalogiannidis I, Katsikis I, uPanidis D. Genetics ye-Polycystic Ovary Syndrome. Hippokratia . 2009; 13 (4): 216-223.