I-Inositol ibonisa isithembiso njengonyango oluphambili kubo bonke abafazi abane-PCOS ngenxa yokukwazi ukuphucula imiba yokuxilisa nokuzala. Nantsi into oyaziyo.
Ii-Inositols Ziyabathunywa beSibini
I-inositols ezifana ne- myo ne-d-chiro inositol (i-DCI), ngamalungu e-vithamini ze-B kunye necandelo le membrane yeseli. I-Inositol ifumaneka kwizidlo ezifana neziqhamo , iimbotyi, iinkozo kunye namantongomane kwaye zenziwa ngumzimba.
I-Myo ne-DCI basebenza njengabathunywa beesibini abathumela iimpawu ezibandakanya umgaqo-insulin. Kukholelwa ukuba abafazi abane-PCOS banokuba nethuba kumandla omzimba wokuguqula i-MYO kwi-DCI, negalelo ekukhuseni kwe-insulin kunye nokungabikho komntwana. Ukuxhaswa nge-inositol kuxhomekeke kakuhle (akukho ziphumo ze-GI ezifana ne-metformin) kwaye iboniswe ukuphucula amanqanaba e-insulin nokunciphisa ukuthanda okukhulu.
Umxube weMyo noD-Chiro Work Best
Uphando olutsha kumphumo ye-inositol luye lwafumanisa ukuba uninzi lwezicubu zomzimba zinomlinganiselo we-myo ukuya kwi-DCI ye-40: 1. Ukuthabatha ukuhlanganiswa kwezi zixhobo zombini kule mali kunokuba nje uthathe i-myo okanye i-DCI yedwa, kucetyiswa.
Xa kuthelekiswa ne-myo inositol, udibaniso lwe-myo ukuya kwi-DCI lubonise ezinye iingenelo zokuphucula iziphazamisi zamathambo (ukunciphisa i-insulin, i-cholesterol, kunye nabamakishi abatshitshisiweyo) kubasetyhini abane-PCOS.
Xa kuthelekiswa ne- metformin , ukuhlanganiswa kwe-myo kunye ne-DCI kwisilinganiselo se-40: 1 kubonise iziphumo ezingcono ngokubhekiselele ekulahlekeni kwesisindo, ukuvuthwa, kunye nokukhulelwa (46.7 vs.11.2%).
I-Inositol Ratio ithinta i-Egg Quality kunye neNzala
Ukungalingani kumlinganiselo womzimba womzimba we-myo kuya kwi-DCI ratio kunokuchaphazela umgangatho weqanda. I-Myo inositol iye yaboniswa ukuphucula umgangatho weqanda kubasetyhini abane-PCOS kanti i-DCI elawulwa kumayeza aphezulu (600-2400 mg yemihla ngemihla) ifumaneka kakubi kumgangatho we-oocyte kunye nempendulo ye-ovari.
Ngaphezu koko, i-dose ephezulu ye-DCI (kunye nokulinganisa okungaphezulu kwe-MYO ukuya kwi-DCI), ukugqithisa ngakumbi umgangatho we-oocyte kunye nokuphendula kwe-ovari.
I-Inositol May iyanciphise Umngcipheko weSifo soSwesigqirha soGestation
Kuye kucetyiswa ukuba abafazi abane-PCOS basenokuba besengozini yokwanda kwesifo sikashukela (GDM) ekukhulelweni. Ucwaningo luye lwabonisa ukuba ukuxhaswa ne-myo inositol ngexesha lokukhulelwa kusebenza ngempumelelo ekunciphiseni umngcipheko we-GDM kwabasetyhini abakhulu kakhulu kunye nabasetyhini abane-PCOS. Uphando lwe- Gynecology Endocrinology lubonise ukuxhaphaka kwe-GDM phakathi kwabasetyhini abakhulelwe ne-PCOS abathi bathatha i-myo-inositol iqela liyi-17.4% ngokumalunga no-54% kwiqela lolawulo.
Imithombo
Hamid A et al. I-Journal Based Health Health Journal. 2015; 5 (3): 93-98.
U-Anna R1, uDi Benedetto V, uRizzo P, uRaffone E, i-Interdonato ML, i-Corrado F, i-Di Benedetto A. I-Myo-inositol inokuthintela isifo sikashukela kwi-PCOS yabasetyhini. Gynecol Endocrinol. 2012 Juni; 28 (6): 440-2.
I-Costantino D, i-Minozzi G, i-Minozzi E, i-Guaraldi C. I-Metabolic nemiphumo ye-hormone ye-myo-inositol kubasetyhini abane-polycystic ovary syndrome: ityala le-doubleblind. Uhlolo lwe-Europ med medolol sci. 2009; 13 (2): 105-110.
Unfer V, uCarlomagno G, uRizzo P, uRaffone E, uRoseff S. Myo-inositol esikhundleni seD-chiro-inositol uyakwazi ukuphucula umgangatho we-oocyte kwimijikelezo ye-sperm injection. Uvavanyo olulindelekileyo, olulawulwayo, oluhleliweyo. Uhlolo lwe-Europ med medolol sci. 2011; 15 (4): 452-457.
Le Donne M, Alibrandi A, Giarrusso R, Lo Monaco I, Muraca U. [Ukutya, i-metformin kunye ne-inositol kwindoda enomzimba ogqithiseleyo kunye nogqithiseleyo nge-polycystic ovary syndrome: iziphumo ekubunjweni komzimba]. Minerva ginecologica. 2012; 64 (1): 23-29.
I-Venturella R, Mocciaro R, De Trana E, D'Alessandro P, Morelli M, Zullo F. [Uvavanyo lokuguqulwa kwekliniki, i-endocrinal kunye ne-metabolical profile yegulane nge-PCOS syndrome ephathwa nge-myo-inositol]. Minerva ginecologica. 2012; 64 (3): 239-243.
Genazzani AD, Prati A, Santagni S, et al. Impendulo ye-insulin eyahlukeneyo kwi-myo-inositol yokulawulwa kwezigulane ze-ovary syndrome ezigqithiseleyo. Gynecol Endocrinol. 2012; 28 (12): 969-973.
UGerli S, uPapaleo E, uFrrari A, uDi Renzo GC. I-Randomized, i-trialbo elawulwa yi-placebo eyimpumputhe ephindwe kabini: iziphumo ze-myo-inositol kumsebenzi we-ovari kunye nezinto ezinokusetyenziswa kwamanzi kunye ne-PCOS. I-Europ rev med pharmacol sci. 2007; 11 (5): 347-354.
URaffone E, uRizzo P, uBenedetto V. I-insulin i-agents enyanzelisayo yedwa kunye nokunyanga ngokunyanga kunye ne-r-FSH ukwenzela ukutyunjwa kwe-ovulation kwi-Women's PCOS. Gynecol Endocrinol. 2010; 26 (4): 275-280.
Galazis N, Galazi M, Atiomo W. d-Chiro-inositol kunye nokubaluleka kwayo kwi-polycystic ovary syndrome: ukuhlaziywa okucwangcisiweyo. Gynecol Endocrinol. 2011; 27 (4): 256-62
Papaleo, E., Unfer, V., Baillargeon, JP, et al. (2007). I-Myo-inositol kwizigulane nge-polycystic syndrome syndrome: Indlela yokufunda yokunyusa i-ovulation. I-Endrocrinology ye-Gynecological, 23 (12): 700-703.
D 'Anna R, Di Di Benedetto V, Rizzo P, et al. I-Myo-inositol inokuthintela isifo sikashukela esikwi-PCOS. Gynecol Endocrinol. 2012; 28 (6): 440-442.
U-Isabella R, uRaffone E. Ngaba i-ovary idinga iD-chiro-inositol? J Ovarian Res. 2012 Meyi 15; 5 (1): 14.
I-Dinicola S1, i-Chiu TT, i-Unfer V, i-Carlomagno G, i-Bizzarri M. Ingqiqo ye-myo-inositol kunye no-D-chiro-inositol unyango oluhlangeneyo lwe-polycystic ovary syndrome. J Clin Pharmacol. 2014 Oct; 54 (10): 1079-92.
I-Nordio M, i-Proietti E. Ulwaphulo oluhlangeneyo kunye ne-myo-inositol kunye ne-D-chiro-inositol kunciphisa umngcipheko wesifo se-metabolic kwii-PCOS ezigulisa kakhulu izigulane xa kuthelekiswa ne-myo-inositol yongezwa yodwa. Eur Rev Med Pharmacol Sci. NgoMeyi ka-2012; 16 (5): 575-81.
Colazingari S, Treglia M, Najjar R, Bevilacqua A. Ulwaphulo oluhlangeneyo lwe-myo-inositol kunye no-D-chiro-inositol, kunokuba iD-chiro-inositol, luyakwazi ukuphucula iziphumo ze-IVF: iziphumo zolu vavanyo olulawulwa ngononophelo. I-Arch Gynecol Obstet. 2013 Dec; 288 (6): 1405-11.