Amachiza amasha, ummiselo, okwangoku usetyenziselwa ukuphatha isifo se-Alzheimer, ungabonakalisa isithembiso ekwenzeni unyango. Ukuba kuboniswa ukuba lunomphumo obuncedo ekutheni uphinde uhlaziye, kuya kuba yilungu lokuqala lokuphatha ngokukhawuleza isifo.
Iimvavanyo ezikhoyo ezikhoyo ezisetyenziswayo emva kokuphazamiseka kungakhange ziphathe ngokuthe ngqo ukubethelwa ngokwayo.
Ulawulo lwezolimo olunexesha elikhoyo lujoliswe kwizinto eziliqela:
- Ukugcina uzinzo lwezobugqirha ngamanyathelo afana nokulawulwa kwamanzi kunye ne-electrolyte ukwenzela ukuba kulungiswe ukuhlaziywa kwesifo.
- Ukunciphisa amathuba omnye uhlaselo ngokuthintela ukwakheka kwegazi, rhoqo ngokusebenzisa igazi elincinci.
- Ukuchonga nokulawula imingcipheko yengozi ye-stroke njenge-hypertension, isifo senhliziyo, isifo sikashukela kunye ne-cholesterol ephezulu.
Yintoni iMemantine?
I-Memantine yonyango elitsha ngoku elisetyenziswayo ukunyanga iimpawu zezinye iintlobo zeengqondo. Eyaziwayo ngegama loshishino uNamenda, liye laboniswa ukuba liphumelele ngokukhawuleza ekuthintela ukuqhubela phambili kweempawu zezinye iintlobo zomqondo weengqondo. Kuye kwavunywa yi-United States Yokutya kunye nezoLawulo lweeDrama ukwenzela unyango lwe-Alzheimer's disease esisisigxina, esona sesinye sezizathu eziqhelekileyo eziqhelanisiweyo zengqondo.
I-Memantine isebenza njani?
Inkqubo yesenzo sommangalo ikholelwa ukuba iyindawo yokuvimbela imichiza ebizwa ngokuba yi-glutamate.
I-Glutamate iboniswe ukuba ibangele ukungonakaliswa kwee-neurons (iiseli zengqondo) ngokusebenzisa inkqubo yeekhemikhali ebizwa ngokuba ngumonakalo we-neuro excitatory. Olu hlobo lwenzondo yesifo sengqondo yesifo sengqondo ngenye yeendlela ezidlala indima kwimiphumo yengqondo eyenzeka ngenxa yesigxina.
I-stroke yiziganeko eziphazamiseka ukuphazamiseka kwegazi kwiinkonzo.
Impembelelo yokuphazamiseka kwegazi (ischemia) kwingqondo kuthiwa yi-infarction. Infarance kuthetha ukuba iisisu zengqondo zineziphumo ezinobungozi kwaye zingaba zingasebenzi, ezibangelwa ukukhubazeka ngokomzimba nangokwengqondo emva kokuphazamiseka. Ngaloo ndlela, ukuvinjelwa kwe-glutamate kungavimbela umonakalo ongenayo i-neurotoxic, ukunciphisa umonakalo obangelwa yinto.
Amachiza anokunciphisa indawo yokulimala komzimba ngokuqinisekileyo iya kuba yimpumelelo ekulawulweni kwesifo. Nangona kunjalo, kwanokuba uphumelelo olunokwenzeka kufuneka luhlolwe ngokupheleleyo ukuqinisekisa ukuba lusebenzayo.
Kuze kube ngoku, uphando lubonisa ukuba imeminine inokunciphisa indawo yeengxube zeengqondo eziphazamisekileyo kwaye zenze umsebenzi we-neurological kwiimiceba ezine-stroke, ngoko ke kungenzeka ukuba isebenze ngendlela efanayo kubantu.
I-Memantine Yayisetyenziswe njani Ukuphatha iStyroke
Kukho iiphononongo ezimbalwa ezivavanya imiphumo yommiselo kubantu. Ngokomzekelo, uvavanyo olusandul 'ulungelelwaniso olusandul' ulungelelaniso olwenziwe ngokutsha, olwenziwe ngokuphindaphindiweyo, oluphinda luphindwe kabini, lube luhlola i-placebo e-Spain lihlolisise abasindileyo abangama-28 abanesifo se- aphasia (ukunciphisa amandla okuthetha) emva kwesifo . Abathathi-nxaxheba abafumana unyango nge-memantine babonisa ukuphucula ngakumbi ekukhulumeni njengoko bebuyiselwe kwimivimbo yabo kunabo abangazange bamkele amayeza.
Ixesha elizayo leMemantine ngeStroke
Kuhlala kunzima ukuqikelela ukuba yiyiphi imishanguzo eya kuphuhliswa kwaye ivunyiwe ukwenzela unyango lweengxaki zonyango. Ngokuqhelekileyo, amachiza amatsha aqinisekisiwe ukuba asebenzayo kwaye afunyanwanga ukuba abe nemiphumo emibi yecala anokufumana imvume yokuvunywa kunye nokusetyenziswa ngokuqhelekileyo. Ngaloo ndlela, i-memantine ibonakala ithembisa, ngokukodwa kuba sele sele ikhona idatha ekhoyo malunga nokukhuselwa kwimeko yesifo se-Alzheimer.
Okwangoku, iindlela ezininzi ezahlukahlukeneyo zokulondoloza izicubu zengqondo ezifakekileyo ziphandwa, njenge-stem cell transplantation, ukuvuselela ugesi , kunye ne-hypothermia, kodwa akukho namnye oye waphuma waya kusetyenziswa ngokubanzi.
I-Memantine inenzuzo kwezinye zezi ndlela ngenxa yokuba sele iveliswe njengamayeza, nangona kunjalo njengamachiza kwenye imeko ngaphandle kwesifo.
ILizwi
I-Stroke iphakathi kwezigulane ezinkulu zezokwelapha, kwaye ngoku kukho ambalwa kakhulu unyango olusisigxina. Ubuninzi bokuphuculwa emva kokuba kuqhutywe isifo ngenxa yokuba ingqondo iphilisa yedwa kwaye ngenxa yokuba iinkqubo ezinjengezonyango zonyango kunye nokuvuselelwa kwandisa ukuphulukisa nokuphucula ukuphulukiswa komzimba kunye nokuqonda.
Ukuba wena okanye othandekayo unomdlavuza, ugqirha wakho unokukunikwa ngonyango oluhlaziyiweyo, okanye ukuthunyelwa kwezilwanyana eziza kuhlaziywa ngokutsha.
> Imithombo:
> I-memantine igxininisa i-cell apoptosis ngokukhupha umzila we-calpain-caspase-3 kwindlela yokulinga ye-stroke ye-ischemic, u-Chen B, u-Wang G, u-Li W, u-Liu W, u-Lin R, u-Tao J, u-Jiang M, u-Chen L, u-Wang Y, u-Exp Cell Res. 2017 Feb 15; 351 (2): 163-172. i-doi: 10.1016 / j.yexcr.2016.12.028. Epub 2017 Jan 6.
> Ukulungelelaniswa kwengqondo kunye ne-memantine kunye nemithintelo-kubangele unyango lwe-aphasia kwi-post-stroke ephasia engapheliyo: Ucwaningo lwe-ERP, iBarchocho MA, i-Berthier ML, i-Navas-Sánchez P, iDávila G, iGreen-Heredia C, i-García-Alberca JM, iRuiz-Cruces R, uLópez-González MV, Dawid-Milner MS, uPulvermüller F, uLara JP, uBong Lang. 2015 Juni-Julayi; 145-146: 1-10. i-doi: 10.1016 / j.bandl.2015.04.003. Epub 2015 Apr 29.