Icandelo 2 le-3
Njengoko sifunde kwinxalenye eyodwa, Yintoni eyenziwa yi-Post-Exertional Malaise, abantu abanesifo esingapheliyo (i- ME / CFS ) babone ukuhlaselwa okuphawulekayo kwiimpawu emva kokusebenza. Oku kuyimpawu ephawulekayo yesifo kwaye enye abaphandi baye bazama ukuyenza iminyaka. Sinezinto ezininzi esinokuzifunda malunga nale mpawu, kodwa siyazi ukuba izinto ezingafaniyo zomzimba zidibaniswa ne-malaise (post-exertional malaise).
Ukungahambi kakuhle kwemvelo
Abaphandi baye bafumanisa ukungaqhelekanga okuhlobene nomzimba kwiinkqubo ezininzi, kubandakanywa nesistim somzimba, isimiso senzwa esisisiseko kunye nesimo senhliziyo. Okwangoku, nangona kunjalo, abazange bakwazi ukugqiba ukuba ezi ziqhelo ziyimbangela (ii) zePEM. Ukuhlaziywa kuka-2014 kwincwadi yezokwelapha echonge izimpendulo zamaninzi ezithintelo lwe-immune kwi-ME / CFS, ezininzi zazo ezazibophelelwe ukusetyenziswa kunye ne-PEM. Ezi ziquka:
- Impendulo echazwe ngakumbi kwi-system supplement (inxalenye yesistim somzimba sokuzivikela esisinceda izifo ezivela emzimbeni wakho)
- Ukunyuka koxinzelelo lwe-oxidative (uhlobo lomonakalo weselula) oludibaniswe nempendulo ephikisayo ye-antioxidant,
- Ukuguqulwa kwiprofayili yesalathisi yesiginjana sejenjini.
Olunye uphando (uMorris 2014) luhlolisise ukungaqhelekanga okumalunga nezinto ezibizwa ngokuba yi-adenosine triphosphate (ATP), eyona hlobo lombane wamandla. I-ME / CFS ikholelwa ukuba inxulumene nekhono elingenakukwazi ukwenza i-ATP kwizinga le-mitochondrial.
(IMitochondria yimizimba kwiiseli zakho eziguqula izondlo kwi-ATP.)
Uvavanyo lwe-2015 usebenzisa uhlobo lwekhomputha yesifo (Lengert) lubhekisele kumazinga aphantsi aphantsi kwe-ATP, ngokuqhelekileyo eya kubangela izinga lokufa kweeseli. I-reaction response ngeqala nge-ATP ephantsi iholele ekutheni i-immunological stress and stress oxidative, ngokwemodeli.
Abaphandi bathi ukunyamezela ngokuphindaphindiweyo kwenza imeko ibe yimbi kakhulu. Ngo-2012, iphepha elihlola umsebenzi we-mitochondrial kunye ne-ME / CFS (i-Morris) lixubushe ngokungaqhelekanga, kuquka:
- Ukuququzelela iindlela zokuzibulala,
- Amanqanaba okwandisa ama- cytokines angama-pro-inflammatory,
- Amanqanaba anyukliya-kB,
- Iibhola kwimisebenzi ye-mitochondrial, kubandakanywa nokuveliswa kwe-ATP.
Abaphandi bafundisa ukuba le miba inokuthi iholele ekuphelelweni kwe-mitochondrial, okungenani inxalenye, oku kuthetha ukuba xa umzimba ufuna amandla (ngendlela ye-ATP), amandla akakho nje.
Olunye uvavanyo luka-2015 lwalusebenzisa uhlobo lokuskena olubizwa nge-infrared-spectroscopy ukujonga ukusetyenziswa kwe-oksijeni ngexesha lokuzivocavoca. Xa kuthelekiswa nabantu abaphilileyo kwiqela elilawulayo, abathathi-nxaxheba nge-ME / CFS bafunyenwe ukuba banokutshintshwa okungavumelekanga kwimo-oxygen ye-hemoglobin (iprotheni elinebomvu zeeseli ezithwala i-oksijini kwiiseli zakho) emva kokusebenza.
Naliphina inhlanganisela yale miba ingenza igalelo elifanelekileyo kwiPEM. Sekunjalo, abaphandi banomsebenzi omkhulu phambi kwabo. Abanye abaphandi bacebise ukuba ezinye izinto ezingaqhelekanga zingasetyenziselwa umqondiso wokuxilongwa nge-ME / CFS ngelixa abanye bakholelwa ukuba i-PEM ingaba yindlela efanelekileyo yokuba oogqirha bakwazi ukulinganisa ubunzima besifo.
Okubaluleke ngakumbi, xa sifunda ngakumbi malunga noko kwenzekayo emzimbeni ngexesha le-PEM, sisondele ngakumbi ukuba siqonde indlela yokunyanga ngayo.
Funda nzulu
Imithombo:
Lengert N, Drossel B. i-chemistry chemistry. 2015 Julayi; 202: 21-31. Ukuhlaziywa kwe-silico yokunyamezela ukungasebenzi kwi-myalgic encephalomyelitis / chronic tiredness syndrome.
Miller RR, et al. Umbhalo weyeza lokuguqulela. 2015 Meyi 20; 13: 159. Ukuvavanya okuvakalayo ukuvavanya kunye ne-infrared-spectroscopy kwi-myalgic encephalomyelitis / engapheliyo yokugulisa izigulane ezinokuqhathaniswa nokulawulwa kwempilo: uphando olulawulwa yimeko.
UMorris G, uMees M. Iingcebiso zezoNyango. 2012 Nov; 79 (5): 607-13. Ukwanda kwe-nyukliya-kB kunye nokulahlekelwa kwe-p53 ziindlela eziphambili kwi-myalgic encephalomyelitis / chronic fatigue syndrome (ME / CFS).
UMorris G, uMees M. Izifo zobuchopho zengqondo. 2014 Mar; 29 (1): 19-36. Izidakamizwa zeMitochondrial kwi-myalgic encephalomyelitis / chronic fatigue syndrome echazwe yindlela eyenziwa yindlela yokugonywa kwamanzi, okuyi-oxidative kunye ne-nitrosative.
Nijs J, Nees A, et al. Ukuphonononga ukuhlolwa kwe-immunology. 2014; 20: 94-116. Ukuphendula kwamagciwane okuthintela ukusetyenziswa kwezigulane ezinesifo esingapheliyo sokugula / i-myalgic encephalomyelitis: uhlalutyo lwencwadi oluchanekileyo.