Uvavanyo lwegazi lokuphonononga lusiza ukuchaza iziphumo zempilo
Ukulinganisa i-CD4 T-cell kubalulekile ekuncediseni oogqirha ukuba banqume isigaba kwaye mhlawumbi isiphumo sosuleleko lwe-HIV. Nangona bengasasetyenziselwa ukujonga ukuba unyango lwe-HIV kufuneka luqaliswe njani-unyango kufuneka luqaliswe ngexesha lokuxilongwa- lingawunikela oogqirha ingcamango ecacileyo yendlela umntu kwaye yintoni enokuyenza ukuze kuphuculwe ixesha lakhe elide impilo.
Ukuqonda iCD4 kunye neCD8 T-Cell
Ukuqala, i-lymphocytes zihlobo lwegazi elimhlophe elenza umzimba uphuzelele isifo. Kukho iintlobo ezimbini ezibalulekileyo ze-lymphocytes: i-B-lymphocytes kunye ne-T-lymphocytes. Kulezi zimbini, kukho iintlobo ezimbini zeeseli ze-T esizijongayo ngexesha losulelo lwe-HIV:
- Ii- CD4 T-cell ezise-T-lymphocyte ezinama-molecule abiza i-CD4 emzimbeni. Baqala ukuphendula ngomzimba ngokusayinisa amanye amaseli omzimba okuzivikela ukuze aphethwe yizilwanyana ezinjenge-bacteria kunye neentsholongwane.
- I-CD8 T-cells ezise- molecule kwi-CD8. Lawa "i-killer" T-lymphocytes ejongene nokutshabalalisa amaseli anesifo kunye nokuvelisa izidakamizwa ezikhuselekileyo ezilwa nezifo ezithathelwanayo.
Ixabiso le-CD4 Count Absolute
Inani le-CD4 elipheleleyo lilingana lingaphi i-CD4 T-cell esebenzayo ejikelezayo egazini lakho. I-low ye-CD4 count, i-weakest response response.
Inani le-CD4 elipheleleyo lilinganiswa novavanyo olulula lwegazi, iziphumo zazo ezichazwe njengenani leCD4 cells nganye ngeyubhijimitha yegazi. Abantu abangenayo i-HIV banamanani amaninzi e-CD4 phakathi kwama-600 no-1200 i-CD4 iseli nganye nge-cubic millimeter. Ngokwahlukileyo, abantu abaxhaswe ngumzimba abane-HIV babala ukuba bangaphantsi kwama-500, ngokuxhomekeke kwinqanaba lokusuleleka, ngelixa abantu abane-HIV ephezulu banakho ama-CD engama-200 okanye angaphantsi kwee-cell T-cell nge-cubic millimeter.
Inani elipheleleyo le-CD4 libhekwa njengethuluzi elifanelekileyo ekufuneka liqikelele ingozi yokuqhubela phambili kwe-HIV.
Oko i-CD4 Percentage isitshela yona
Ipesenti ze-CD4 imele ipesenteji yee-lymphocytes ezipheleleyo zee-CD4 zee-cell kwaye zilinganiswa kusetyenziswa ukuhlolwa kwegazi elifanayo njengokuba kukho i-CD4 count.
Ngokuqhelekileyo, abantu abangenayo i-HIV baya kuba neepesenti ze-CD4 malunga neepesenti ezingama-40, ngelixa i-CD4 yabantu abanesifo se-HIV ingaphantsi kwama-25 ekhulwini okanye ngaphantsi. Ngokucacileyo, iphakamileyo yepesenti, iimpendulo ezikhuselekileyo zomzimba.
Ukuba inani lakho le-CD4 liphantsi kunokuba ulindele, ipesenti ze-CD4 zingayifaka kwimeko engcono ngokuzixelela ukuba ngaba oku kutshintsho okanye ukutshintshela.
I-CD4 / CD8 Ukulinganiswa njengeStapshot of Health Immune
Enye indlela yokufumana ukuqonda okungcono komzimba wesigulane ngumgudu wokuhlola isifo se - CD4 / CD8 yesigulane, esivavanya inani le-CD4 T-iseli ngokuthelekiswa nenani lama-CD8 T-cell. Ngolu vavanyo, sinokubona ukuba eso sifo siphuthuma ngokulandelela ukutshitshiswa kwe "killer" kwiiseli ze-T kwiisampula zegazi.
Ngokuqhelekileyo, ekuphuculeni izifo, njengoko isistim somzimba siphelile , asikwazi ukuvelisa i-T-cell ukuze ikhusele. Ipesenti zeCD4 / CD8 zisinceda sibone oku.
Kwiminyaka yakutshanje, kugxininiswe ngakumbi kwi-CD4 / CD8 enamandla kwi- HIV yabantu abadala . Uphando lwezonyango olutsha luye lwacetyiswa ukuba izigulane kwi-ART esebenzayo, kunye ne-CD4 / CD8 ephantsi, inomngcipheko ophezulu wokungabikho kwe-HIV kunye nokufa.
Kutheni ezi Zivivinyo zibalulekile
Inani elipheleleyo le-CD4 kunye neepesenti ze-CD4 zinika ugqirha wakho umfanekiso wezempilo lomzimba wakho, kunye nokuchazwa kwesifo sakho ngokuya phambili.
Ngendlela elula kakhulu, siyazi ukuba ii-CD4 izibalo ezingaphantsi kwama-200 zibeka umntu onentsholongwane kaGawulayo emngciphekweni wokusuleleka . Ipesenti ze-CD4, okwangoku, ithathelwa ingqalelo inani elipheleleyo le-lymphocytes kwaye yinto engakumbi yokuqikelela kwimeko yempilo yomntu kunye nexesha elide.
Ukuba, ngokomzekelo, inani le-CD4 liphezulu kuphela kuba inani le-lymphocyte liphezulu, siya kuba nesisifo sokukhathazeka ngempilo yesigulane. Ukuba, ngakolunye uhlangothi, i-CD4 iyancipha ngenxa yesibalo se-lymphocyte esezantsi, sinokuyichaza iziphumo ezahlukeneyo.
> Umthombo:
> Gompels, M .; Dunn, D .; Phillips, A .; okqhubekayo. "Ngaba i-Discordance phakathi kwe-CD4 Bala kunye ne-CD4 Ipesenti kubantu abane-HIV abaneempembelelo ezichaphazela iziphumo kwi-Highly Active Antiretroviral Treatment?" J Disfect Dis. 2012; 205 (4): 540-547.
> I-Sauter, R .; Huang, R .; Ledergerber, B; okqhubekayo. Umlinganiselo we-CD4 / CD8 kunye neengxelo ze-CD8 ziqikelela ukuphendula kwe-CD4 kwisifo se-HIV esingenasifo esine-HIV-1 kunye nezigulane kwiCART. " Mayeza. 2016; 95 (42): e5094.