Kutheni i-Bevyxxa ibhalwe
I-Bevyxxa, eyaziwa nangokuthi yi-betrixaban, yigazi elincinci elivunyiweyo yi-Food and Drug Administration ekusebenziseni kwizigulane zezonyango ezibhedlele. Ukuthetha ngokusemthethweni, eli liyeza liyi-Factor Xa inhibitor, oku kuthetha ukuba i-Bevyxxa ilibaziseka inkqubo yokuqhawula igazi ukwenzela ukukhusela i-clotting.
Kubalulekile ebomini ukuba igazi lifake iiflothi, mhlawumbi sasiya kufa emva kokuba i-papercut engazange iyeke ukuphuma, okanye ivela kwikhulozi enegazi.
Ukuba igazi alizange linyamezele, asiyi kuphila esona sikhulu kunobungozi, kodwa igazi elivalwe kakuhle linokubangela iingxaki ezinzulu.
Kwizigulane zasezibhedlele, umngcipheko wee-clots zegazi zihlala ziphakamileyo kakhulu kunomngcipheko wokuphuma kwegazi kakhulu. Ngenxa yeso sizathu, amayeza anikezwa "athambisa" igazi kwaye enze igazi lithathe ixesha elide ukuvala. Oku kunokuthintela ukwakheka kwamacwecwe emzimbeni.
I-Bevyxxa Yenzani
Igalelo legazi lisetyenziselwa ukwenza igazi lithathe ixesha elide ukwenza ama-clots, anokunciphisa ingozi yeengxaki ezinzulu kunye nobomi obubangelwa ngamacenge egazi. Ngelixa abantu abaninzi bathatha i-blood thinners imihla ngemihla ngenxa yesimo senhliziyo esaziwa ukuba senze i-clots, i-Bevyxxa iyasetyenziswa ukukhusela uhlobo oluthile lwe-clot edla ngokuqhelekileyo ngexesha lokuhlala esibhedlele ukugula.
La maqhekeza egazi ahlala eqheleka ekupheleni-kakhulu imilenze-imeko eyaziwa njenge- vein thrombosis (DVT) .
Kwezinye iimeko, i-clot eyenziwe emlenzeni okanye ingalo iya kukhulula kwaye iqalise ukuhamba ngegazi, ukuhlala kwimpompo apho ibe yimeko ebungozi yobomi obubizwa ngokuba yi- pulmonary emobolism , okanye i-PE.
Kwizigulane zezibhedlele ezingalindelekanga ukuba zenziwe utyando, i-Bevyxxa iboniswe ukukhusela iifom yegazi zombini esibhedlele nasemva kokukhutshwa.
Ngaphambi kokuvunywa kweBexxxa, kwakukho imithi emibili esetyenziselwa injongo efanayo, i- Heparin neLovenox (enoxaparin). Bobabini la mayeza asetyenziswa esibhedlele, kodwa anikezwa njengamajoni ukwenzela ukuba izigulane kufuneka zitshintshelwe kumayeza ahlukeneyo asetyenziselwa ekhaya.
Ngokungafani neHeparin kunye neLovenox, i-Bevyxxa ingasetyenziselwa esibhedlele kwaye emva kokukhutshwa ukukhusela ama-clots, njengoko unyango lithathwa njengepilisi, kunokuba lube ngumjovo.
Kutheni i-Bevyxxa isetyenzisiwe
I-Bevyxxa ivunyiwe yi-FDA ukuba ikhutshwe ebantwini kwaye iya kubonakala kwizibhedlele kunye nee-pharmacy ukuze zisetyenziswe kubantu abasemngciphekweni wokwenza i-clot yegazi. Izigulane ezibhedlele zifumana ingozi enkulu yokwenza i-blood clot, kwaye isigulane isiguli, ngokuqhelekileyo, siphezulu kwengozi. Ngenxa yoko, amayeza atholakala ukuba athinte ukubunjwa kwegazi.
I-Bevyxxa ihluke njani
Kwiingcaphephe, i-Bevyxxa yayisebenza ngempumelelo ngakumbi kuneenjini zeLovenox (enoxaparin). Ukwahlukana okwenene phakathi kweBexxxa kunye neyeza ngoku kusetyenziswe ukuphindaphindiweyo kwe-dosing kunye nendlela yokulawula.
I-Heparin ilawulwa ngokuphindwe kabini okanye kathathu ngosuku kwaye i-injection. I-Lovenox nayo ijojo kwaye inikwa kanye ngosuku.
Ukongezelela, ii-injections azikwazi ukuqhutyelwa ekhaya kwaye isiguli kufuneka sitshintshelwe kumayeza ahlukeneyo-inkqubo engakhokelela kwizibhedlele ezide kwezinye iimeko-ngoko inzuzo yangempela ku-Bevyxxa kukuba isigulane sinokuyithatha esibhedlele nasekhaya.
Ixabiso lale mayeza lingazange lishicilelwe ngoJulayi 2017, ngoko kuyacaca ukuba ixabiso liyancintisana neziyobisi ezikhuphisanayo kunye noHeparin noLovenox. Akunakwenzeka ukuba le myeza entsha iya kuba yabiza ngaphaya kweCoumadin (warfarin), efumaneka kwi-generic.
Kulindeleke ukuba i-Bexxxa ibe yintengo ekhuphisanayo kunye namanye amachiza amancinci egazini amasha athathwe kwipilisi ngaphandle kwesibhedlele, njengo-Eliquis, Pradaxa noXarelto.
I-Bevyxxa ithathwa njani
I-Bevyxxa ithathwa ngomlomo kwipilisi, mhlawumbi ngokutya, kanye ngosuku. Kukulungele ukuthatha le nyanga ngexesha elifanayo iziphumo ezilungileyo.
Iingozi zeBexxxa
Njengazo zonke i-blood thinners, i-Bevyxxa iya kwandisa amathuba okuphuma kwegazi. Oku kunokuthetha ukuba isilonda esiqhelekileyo, esinjenge-papercut, siya kuphuma ixesha elide kwaye lide kunokuba lingaba nalo ngaphambi kokuba uthathe le nyilisi. Umncinci omncinci xa ukucheba kungabangela igazi elingaphezulu kunelo liqhelekileyo, kwaye kuyafana nokuphuma kwindoda okanye ukulimala. Le ngozi eyaziwayo yokuthatha bonke abagcini begazi kwaye ayilona i-Bevyxxa ngqo.
I-Bevyxxa ayinayo i-agent eguqukayo, nto ithetha ukuba akukho myeza eyaziwayo eyenza umphumo we-Bevyxxa umise ngokukhawuleza xa kwenzeka ukuphuma. Oku kungenza kube nzima ukuyeka ukuphuma kwegazi xa kukho ukulimala okubuhlungu, ukuphuma kwangaphakathi okanye ezinye iintlobo zokuphaphaka. Ukuba ukuphuma kwegazi kunzima okanye ukwesongela ubomi, ukunyuswa kwegazi ukubuyisela ukulahlekelwa kwegazi kuya kuba yonyango olululo.
Ukuqhaqhaza kunokuba kubaluleke kakhulu xa uthatha i-Bevyxxa okanye nayiphina imveliso yegazi elincinci. Ezinye iimpendulo ezingahambelani nokuphuma kwiimvavanyo zamachiza kulo myeza zibandakanya:
- Usulelo lwe-Urinary tract (UTI)
- Ukutyunjwa
- I-potassium ephantsi
- Igazi elonyukayo
- Intloko
- I sizathu
- Uhudo
Nini ukubiza uDokotela wakho
Nangona ukuphuma kwegazi kunokuqhelekileyo kunye nabagcini begazi, akuqhelekanga ukuba ube negazi kwisimo sakho, imeko ebizwa ngokuba yi-melena. Akuqhelekanga ukuba ubone igazi kumchamo wakho, esinye isibonakaliso sokuphuma kwegazi akumele sibe khona. Ngaphandle kwezi zimpawu, ngezantsi ziminye imizekelo xa ufumana ugqirha malunga nokusetyenziswa kwegazi elincinci:
- Inwele embi
- Utywala okanye ukungabi nakuthathaka
- Intlungu engachazwanga, kuquka intlungu edibeneyo
- Iifom
- Ukunyuka kwesisu
Ukuba uthatha i-Bevyxxa kakhulu, biza ugqirha wakho okanye uye kwigumbi eliphuthumayo elisondeleyo.
Ukuba unamava amnyama okanye i-tarry, uhlanza kwaye ubone oko kukhangeleka njengeendawo zekhofi, okanye ube negazi kumchamo wakho (obomvu, obomvu, okanye umchamo obomvu), kufuneka ubizele umnonophelo wakho wezempilo ngokukhawuleza.
Nayiphi na inzakalo yentloko, njengokuwa okuphumela ekubetheni intloko, kufuneka kwakhona kuxelwe. Kulula kakhulu ukuba ne-episode of bleeding on the brain xa uthabatha olu hlobo lonyango, kwaye unyango olukhawulezayo luqaliswa ngcono kwisiphumo sokugqibela.
Ngubani ongafanelanga ukuthatha i-Bevyxxa
- Njengawo onke amachiza amancinci yegazi, i-Bevyxxa akufanele ithathwe ngumntu onokuphuma kwamanzi.
- La mayeza awazange afundwe ukusetyenziswa kwizigulana zezilwanyana.
- I-Bevyxxa ayizange isetyenziswe ekusebenziseni kwabasetyhini abakhulelweyo okanye besetyhini. Ukusetyenziswa kwabasetyhini abakhulelweyo okanye abahlengikazi kufuneka baqwalaselwe kuphela xa iinzuzo zokucuthisa igazi zikhulu kuneengozi zokwenza njalo. Ekubeni i-Bevyxxa ingazange ifundwe kubasetyhini besondlo, kukhuselekile ukukhusela ukutshatisa intsana kumachiza kwaye isebenzise ubisi olongezelelweyo endaweni yoko.
- Izigulane ezinobunzima bokugawula ngegazi akufanele zithathe eli gciwane.
- Izigulane ezineesifo seengtso zingadinga ukuba idosi yemihla ngemihla iyancipha.
- Abantu abanezifo zesibindi akumele basebenzise le mayeza. Isifo sesibindi sinokunciphisa amandla omzimba ukuba aphephe kwaye angakhokelela kwiimeko ezinzima xa uthatha le mayeza.
- Izigulane ezineentsimbi zentliziyo ezingenziwanga zifundwe, ngoko ayaziwa ukuba ngaba le nyeza iphumelela kulabo bantu.
- Izigulane eziseBexxxa kwaye ziya kuba ne- anesthesia yomgudu okanye i-epidural anesthesia zisengozini ephezulu ye-hematoma, iqoqo elikhulu legazi kwindawo yokuqhawula. Ngoxa le nto ingenakuvakala njengembambano ebalulekileyo, kwiimeko ezinzima oku kunokukhokelela kumonakalo wamanqatha okanye mhlawumbi ukukhubazeka.
- Abasetyhini abaneminyaka yokubeletha abantwana kufuneka basebenzise la mayeza ngokulumka njengoko ukuphuma kwindoda kunokubaluleka ngale mayeza. Abasetyhini abanegazi elininzi abanokufumana isifo se-anemia okanye nokuba negazi ngenxa yonyango okanye nayiphi na igazi elincinci. Ukuba uceba ukukhulelwa, xubusha iinqwenela zakho kunye nogqirha wakho.
- Izigulane ezithatha amanye amachiza awaziwayo ukwandisa umngcipheko wegazi, njenge-aspirin, ezinye iilpress, i- ibuprofen kunye ne-naproxen , kunye nabanye abagcini bamagazi basengozini enkulu yokukhathazeka okukhulu kwegazi.
Ukunyuka kweBexxxa
I-dosing ye-Bevyxxa iyona dose yokuqala ye-160 milligram (mg) elandelwa ngumthamo we-80 mg. Amanyathelo kufuneka anciphise kwizigulane ezinezifo ezinzima zesifo. Eli thuba liye lafundiswa ukusetyenziswa kwiiveki ezi-5 ukuya kwe-7, ixesha elide lokusetyenziswa liyakwenzeka, kodwa ulwazi alukafumaneki.
I-Bevyxxa ifumaneka kwi-40mg okanye 80 mg dose amandla. Izigulane ezithatha amachiza aqhelekileyo alandelayo, eziyi-P-glycoprotein inhibitors, ziza kufuna amaqondo amancinci e-Bevyxxa:
- Amiodarone (iCordarone)
- Azythromycin
- Clarithromycin
- Cyclosporine
- Colchicine
- Diltiazem
- Erythromycin
- Felodipine
- Ketoconazole
- Lansoprazole (Prevacid)
- Omeprazole (Prilosec)
- Nifedipine (Procardia)
- I-Paroxetine (Paxil)
- Sertraline (Zoloft)
- Quinidine
- Tamoxifen
- IVerapamil
Ukuba Ulahlekelwa Umthamo we-Bevyxxa
Ukuba ulahlekelwa umthamo weli gulana, kwaye idosi yakho elandelayo ikhefu ezisibhozo okanye ngaphezulu, thabatha idilesi ephosakeleyo. Ngaphandle koko, kufuneka uwebe umthamo kwaye uthathe umthamo wakho olandelayo njengoko uhleliwe.
ILizwi
I-Bevyxxa yile mveliso emitsha yerhwebo evunywe yi-FDA ngoJuni ka-2017 ukuze isebenzise kwizigulane ezingabonanga kwizibhedlele ngexesha lokulaliswa kwezibhedlele kwaye ngexesha lokuphucula. Ngeli xesha lo kubhala, i-Bevyxxa ayifumanekanga kuluntu jikelele. Nangona iziphumo zokuqala ezivela kwizifundo ezenziwe kulo mayeza zithembisa, ulwazi oluninzi malunga nokusetyenziswa kwexesha elide, iziphumo ezibi, iingozi kunye neenzuzo ziya kufumaneka njengoko izigulane ezininzi zisebenzisa iyeza.
Ngeli xesha, uphando lubonisa ukuba le nyilisi inokuthintela izigulane kwizigulane ngexesha lokuhlala kwisibhedlele kwaye kwiiveki zokubuyiselwa ezilandelayo, kwaye zisebenza ngokufanelekileyo okanye ziphumelele kunamanye amayeza afanayo.
> Umthombo:
> Bevyxxa. Iimbali eziphambili zokuLawulwa kolwazi. Ukutya kunye noLawulo lweeMithi. Kufinyelelwe ngoJuni, 2017. https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/208383s000lbl.pdf