Ukuba namazinga aphezulu e-LDL ye-cholesterol anokubeka engozini yokuhlakulela isifo senhliziyo. Izikhokelo zincoma ukuba amazinga akho e-LDL afanele abe phantsi kwe-100 mg / dL. Nangona kunjalo, kungekhona nje ukuba kunamazinga aphezulu e-LDL ye-cholesterol ukubeka engozini yesifo senhliziyo, uhlobo lweengqungquthela ze-LDL ezijikelezayo kwigazi lakho nazo zinokwenza umehluko. Iindidi ze-LDL zinokuluhlula phakathi kwezinto ezinkulu kunye nezixhamla ezincinci.
Iincinci ze-LDL ezincinci ziyakwazi ukuba zi-oxidized, ezenza zibe yingozi ngakumbi kwimpilo yakho ye-cardiovascular. I-LDL ene-Oxidised iyakwenza ukutshaya kwiimitha zegazi ezinika igazi kwizitho zakho nakwezinye izicubu, ngaloo ndlela ukukhuthaza i- atherosclerosis kunye nokwandisa umngcipheko wokuba nesifo senhliziyo okanye isifo.
Ifom ye-Oxidized LDL Ifomu?
I-oxidation ye-LDL kucingelwa ukuba iyenzeka xa i-LDL i-cholesterol inxenye yomzimba wakho isabela ngama-radical ezamahala. I-LDL eneenkomo ngokwayo ibuye isetshenziswe ngakumbi kunye nezicubu ezijikelezayo, ezinokuvelisa umonakalo wesisu. Ezinye zezinto ezibonakala ngathi zandisa amazinga e-LDL aneenkcukacha ziquka:
- Ukutya ukutya okuphezulu kumafutha atshintshe
- Ukutshaya
- Ukulawula kakubi isifo sikashukela
- Ukufunyaniswa ukuba unesifo se-metabolic syndrome
Emva kokuba i-LDL iba ne-oxidized, ihamba ngqo ngaphakathi kwimbane yangaphakathi (endothelium) nayiphi na umthambo emzimbeni, kubandakanywa umthambo we-carotid, umzobo we- coronary okanye imirhobho enika imilenze yakho neengalo ngegazi.
Kanye apho, ikhuthaza ukuqokelela kweeseli ezivuthayo, ezifana ne-macrophages, kunye neeplatelet kwisiza sendawo kunye nokukhuthaza ukunamathela kwabo kwindawo ewonakalisiweyo. Ezinye i-macrophages, i-cholesterol kunye nezinye iipilisi ziqala ukuqokelela kwisayithi, zenza i-plaque eqala ukukhula.
Ngokuhamba kwexesha, oku kunganciphisa - okanye ukukhawulela ngokupheleleyo - inani lokuhamba kwegazi eliya kwindawo enye okanye ezininzi zomzimba. Oku kungakhokelela kwiimeko ezahlukeneyo zempilo, kubandakanya izifo zentliziyo ye-coronary, isifo se-vascular peripheral, okanye i-dementia.
Yintoni Ongayenza Ukukhusela I-LDL Oxidized?
Kukho izinto ezininzi ongayenza ukukhusela ukubunjwa kwe-LDL eneenkomo, kwaye ezininzi zazo zibandakanya ukwenza utshintsho oluthile kwimikhwa yakho yansuku zonke ukunciphisa i-cholesterol yakho ye-LDL , njengale:
- Yeka ukutshaya.
- Ungafaki amafutha atshintshe ekudleni kwakho. Ukutya okunokuthi kuqulethe amafutha atywala kuquka i-pastries, ukutya okuthosiweyo, ii-potato chips kunye nezinye ukutya eziphekwe ngesinqumelo.
- Yongeza izithelo kunye nemifuno ekudleni kwakho. Akukhona nje ukuba ziqulethe ezininzi izondlo kwaye ziphantsi kweoli, nazo zinezixhobo ezichasayo ezinokukhusela izityalo ezinokunceda ukunciphisa i-oxidation ye-LDL.
- Ukuba ufumene ukuba unesifo sikashukela okanye isifo se- metabolic syndrome , fumana ezi zimo phantsi kolawulo. Oku kubandakanya ukulahlekelwa ubunzima, ukutya ukutya okunempilo kunye nokusebenzisa. Ukuba utshintsho lwezinto zokuphila alukukuncedisi ukulawula izinga lakho leshukela legazi kunye nobunzima, umboneleli wakho wezempilo unokuthetha nawe ngokuthatha amachiza ukulawula le miqathango.
Kwezinye iimeko, unokudinga unyango ukuze unciphise i-cholesterol yakho. Ezinye zee-anti-cholesterol-downing medications, ezinjengeemimiselo, nazo zinemihlaba echasayo yokunciphisa i-cholesterol kunye nokukhusela ukuvuvukala okunceda ukuseka ukubunjwa kwe-atherosclerosis.
> Imithombo:
Inkcazo yesithathu yeNkqubo yeMfundo yeSizwe ye-Cholesterol (NCEP) Iqela leNzululwazi ekuFundeni, kuVavanyo kunye nokuPhathwa kwe-Blood High Cholesterol kuBantu abadala (PDF), ngoJulayi 2004, iiNational Institutes of Health: iNational Heart, Lung and Blood Institute.
I-Dipiro JT, i-Pharmacotherapy: Indlela yokuPathophysiological., I-9th edition. Imfundo ye-McGraw-Hill 2014.
Trpkovic A, Resanovic, Stanimirovic J et al. I-Oxidized Low-Density Lipoprotein njenge-Biomarker ye-Cardiovascular Disease. Crit Rev Iiklinikhi zeeLebhu Sci 2015; 52: 70-85