Yintoni Eyabangela Iintlanzi Ezixhambileyo Emva kokusela Utywala?

Kutheni Abanye Abantu Banalo Utywala Baxhatshazela Okwenzekayo Nokuba Yintoni Enokwenziwa Ngayo

Ixesha lobugcisa lokufumana ukutshatyalaliswa kweso sangoko emva kokusela utywala ngotywala.

Ukusetyenziswa kotywala kotywala ngamanye amaxesha kuthiwa yi-Asian flush syndrome, i-Asian flush, okanye ukukhanya kwe-Asia ngenxa ye-36% yama-Asiya aseMpuma (amaJapan, amaTshayina namaKorea) abonakalisa ukutshatyalaliswa kobuso emva kokusela utywala.

Iimpawu ezinxulumene noTywala ziThuthukisa

Iqondo leempawu lihluka ukusuka kumntu ukuya komntu, kodwa ngokubanzi, iimpawu zokutywala kotywala ziquka:

Ukusetyenziswa kotywala kotywala kunokukwenzeka kwi:

Yintoni Eyabangela Ukugqithisa Ubuso Emva kokusebenzisa Utywala?

Emva kokusela utywala, i-enzyme ebizwa ngokuba yi-dehydrogenases (ADH) iguqula utshwala ibe yi-acetaldehyde, i-toxin leyo eyona nto eyenziwa yi-alcoolised alcohol, enye enye i-enzyme ebizwa ngokuthi i-aldehyde dehydrogenase 2 (i-ALDH2) ize ilandele into engabonakaliyo ebizwa ngokuba yi-acetate.

Ukutshatyalaliswa kwesobuso kuthathwa ngendlela eyenzeka kubantu abangenalutho kwi-ALDH2, apho utywala buqulunqwa khona kwaye luqhutywe kumaxesha angama-100 ngokukhawuleza kunomyinge wesintu.

Ukuntuleka kwe-enzyme ye-ALDH2 kuthetha ukuba i-acetaldehyde ikwakhiwa emzimbeni, kubangela ukuhluma kunye nezinye iimpawu ezifana nokunyuka kwentliziyo kunye nesiphithiphithi.

I-ALDH2 iyona-enzyme efanayo ejongene nokucubungula i- histamine- imichiza echaphazelekayo ekuphenduleni-kwaye xa unesiphene kwi-gene ekuncedeni ukuphuza utywala, ufumana utywala obushushu.

Phantse ama-5-7% abantu abane-alcohol reaction reaction bashiywe ngokupheleleyo i-gene.

Ngaba Ukutshatyalaliswa Kwebuso Kubungozi?

Kwiingcaphephe, ukuphendulelwa kotywala kotywala kuye kwadibaniswa nomlinganiselo ongaphantsi kwamazinga okusela utywala (mhlawumbi ngenxa yokubambisana kunye nemiphumo emibi emva kokusela utywala) kunye nama-capillary ehlanjululwayo kunye namahlama atyhidiweyo. Nangona kunjalo, ukusabela ngokutsha kotywala yimeko enxulumene nomngcipheko wokwanda komdlavuza kulabo baselayo.

Abantu abangenalo i-ALDH2 basengozini enkulu yokuphucula umdlavuza we-esophageal (ngokukodwa i-squamous cell carcinoma) ekuphuzeni utywala kunabantu abane-ALDH2 enamandla ngokupheleleyo.

Izindlela zokuLawula ukuqhuma komzimba

Akunakwenzeka ukutshintsha i-enzyme ye-ALDH2, nangona kukho iindawo ezininzi zokusela iimveliso kunye neengxowa-mali ezithi zikuncede ukuba usebenzise i-acetaldehyde. Ukuze unqande ukutshatyalaliswa kotywala kufuneka utshintshe indlela osela ngayo ngeendlela ezimbalwa ezilula:

Umthombo:

Utywala Utywala Amanqaku Ukwanda komngcipheko weCcercer phakathi kwama-Asiya aseMpuma. Ngomhla wama-23 Matshi 2009. Iziko leSizwe lezeMpilo (NIH).