URanexa (ranolazine) isilwanyana esitsha, esineendlela ezikhethekileyo zenzo, ezisetyenziselwa unyango lwe- angina . U-Ranexa uboniswe ngokuphucula kakhulu inani lexesha lezigulane ezine-angina ezizinzile ziyakwazi ukusebenzisa ngaphambi kokuvelisa iimpawu kwaye zavunywa yi-FDA ngo-2008 njenge-arhente yokuqala ye-angina.
Ekuqaleni kwakukholelwa ukuba uRanexa wabangela ukuba isisu senhliziyo sitshintshe ukususela ekusebenziseni i-acids fat to glucose ukuveliswa kwamandla, okuya kuncitshisa inani le-oksijini intliziyo efunekayo ukuze isebenze.
Kutshanje, nangona kunjalo, kukho ubungqina obubonakalayo obonakalisa umphumo oyintloko kaRanexa kukuvimba into ebizwa ngokuthi "umzila we-sodium ngasekupheleni" kwiintsholongwane zentliziyo, ezijongene ne- ischemia , okanye ukungabikho kwe-oksijeni ehambelana ne- atherosclerosis , kwimibhobho ye-coronary . Ukuthintela lo mzila we-sodium kuphucula i-metabolism kwiinhliziyo ze-ischemic, ukunciphisa umonakalo kwimisipha yentliziyo, kunye nokunciphisa impawu ze-angina.
Yintoni Angina?
U-Angina unentlungu okanye ayikhathazi esifubeni esiphumela kwisifo senhliziyo esicatshulwa ngegazi le-oxygen. Abanye bachaza umvakalelo njengengcinezelo okanye ukucima, kwaye ukuphazamiseka kunokuvalelwa kumagxa, ingalo, intamo, umhlathi okanye umva ngaphezu kwesifuba. Intlungu ye-Angina inokuziva ngathi i-indigestion.
U-Angina uyimpawu kunokuba isifo kunye kwaye. Ngokuqhelekileyo, ibonisa isifo senhliziyo senhliziyo (CHD) ngenxa yokunciphisa enye okanye ngaphezulu kweetriyari ze-coronary, ezaziwa ngokuba yi-ischemia.
I-Ranexa isetyenziselwa ukunyanga i-angina engapheliyo, kodwa kukho nezinye iindidi ezininzi ze-angina, kuquka i-angina ye-microvascular, i-angmine ye-Prinzmetal, i-angina ezinzile, i-angina engaqinisekanga kunye ne-angina eguqukayo.
Ranexa Side Effects
Iziphumo eziqhelekileyo ezibiweyo zecala likaRanexa ziyizintloko, ukuzithemba kunye neengcamango.
Ezinye iziphumo ezibi kakhulu zingabandakanya:
- utywala okanye uvakalelwa
- intloko
- umlomo owomileyo
- ubuthathaka
- ukukhala ezindlebeni
Ukongeza, ngelixa uthabatha uRanexa, kubalulekile ukunyamekela nayiphi na imiphumo emibi elandelayo kwaye ufune ukukhokelwa ngokukhawuleza kumgqirha wakho ukuba kwenzeka ntoni:
- uvakalelwa ngathi ungadlula
- ukuvuvukala ezandleni, ezinqeni okanye ezinyaweni
- ukukhawuleza, ukukhawuleza, okanye ukubetha intliziyo
- ukuthuthumela
- igazi kumchamo
- ukuvuthwa ngokungaphantsi kaninzi okanye kungekhona
- ukuqhawukelwa ngumphefumlo
- ukuqhaqhaqhayisa, ukubetha, ukubetha, ukunyanzelisa, intlungu, okanye ubuthathaka
Ekuqaleni, inkxalabo ebalulekileyo malunga neRanexa yinto yokuba inokulondoloza ixesha "le-QT" kwi-ECG (umlinganiselo womsebenzi wombane entliziyweni). Amanye amachiza anolu hlobo anganyusa umngcipheko wokwakha i-arrhythmias yenhliziyo eyingozi . Nangona kunjalo, uphando olunzulu lubonise ukuba umngcipheko ungancinci okanye awunakho noRanexa. Enyanisweni, uRanexa ngoku uye waboniswa ekunciphiseni umngcipheko wokuphuhlisa ama- arhythmias kunye ne-fibrillation ye-atrial .
Ukongezelela, abantu abane-cirrhosis (ukubhubha) kwesibindi akufanele bathathe uRanexa, kwaye akufuneki ukuba abantu bathathe i-wort St. John kunye namanye amayeza:
- izifo zefungus
- sulelo
- ukuxinezeleka
- HIV
- isifo sofuba (TB)
- ukuxhamla
Imithombo:
Chaitman, BR. I-Ranolazine ekwenzeni unyango olungapheliyo kunye nokusetyenziswa kweminye imimoya yomoya. Uhambo luka-2006; 113: 2462.
UMorrow DA, uScirica BM, Karwatowska-Prokopczuk E, et al. Iimpembelelo zeRanolazine kwiziganeko eziphambanisayo zengqondo kwizigulane ezingenabo-ST-elevation aconon syndromes. I-MERLIN-TIMI 36 ilingo lemiqathango. JAMA 2007; 297: 1775-1783.
Belardinelli L, Shryock JC, uFraser H. Indlela yokwenza isenzo se-ranolazine ukunciphisa i-ischemia-eyenziwa i-diastolic ukungasebenzi. I-Eur Heart J Suppl (ngoFebruwari 2006) 8 (i-suppl A): A10-A13. i-doi: 10.1093 / eurheartj / sui091.