Ulwaphulo lweNyango yeChrevercer

by Lynne Eldridge, MD; Ukuphononongwa nguGrant Hughes, MD

Ziziphi iinjongo zoLondolozo lweNyango yeCyrus?

Kusenokwenzeka ukuba uye wakuva malunga nabahlobo kunye nabathandekayo abaye bahlala kwicala lokulondoloza lomhlaza. Nangona kunjalo unyango lokulondoloza umdlavuza wamaphaphu luye lwajongwa nje ngoku kutshanje. Kuphi unyango olusetyenziswayo ngomhlaza wamaphaphu kwaye ziziphi iinjongo zonyango?

Uphi unyango lweSondlo?

Ngaphambi kokuba uqale ukuthetha ngamachiza asetyenziswayo, kunceda ukuchaza ngokuchanekileyo naluphi unyango lokulondoloza.

Ulwaphulo lokulondolozwa luhlobo lonyango olusetyenziswe ngumhlaza wamaphaphu ophezulu - ngokukodwa, umhlaza wesifo somhlaza wamanzi omncinci ongeyomncinci ukuzama ukuphucula ubomi, kodwa "ukunyanga" umhlaza. Oku kuhambelani nonyango oluthile kumanqanaba angaphambili omhlaza womphunga onokunikezwa ngonyango engqondweni.

Ingasetyenziselwa ngamanye amaxesha abantu abanomdlavuza omncinci wamangqamuzana (jonga ngezantsi).

Inkcazo elula yokulondolozwa kweyeza yinkqubo eqhubekayo yokwelapha isisu esingazange siphumelele (emva kokudlulayo) emva kokusuka kwekhemotherapy yokuqala - kude kubekho imiqondiso yokuba umhlaza uye waqhubela phambili. (Ngamanye amazwi, unyango lunikwe Injongo yokugcina isisu esingaqhubeki ngokukhawuleza ekukhangekeni, kungekhona unyango owenzelwe ukunciphisa okanye ukuphilisa isisu.

Iinjongo zoLondolozo lweNyango

Naluphi na unyango lomhlaza ocingayo, kubalulekile ukucinga malunga neenjongo zonyango.

Ngaloo nto ingqondweni, kulula kakhulu ukulinganisela ingozi yonyango malunga nezibonelelo. Ezi zi-4 ziinjongo eziphambili zi:

Ukukhusela
Ulwaphulo
Ukulawulwa kwezifo
I-Palliative

Ulwaphulo lokugcina isetyenziselwa ukulawula izifo. Akukona ukwelashwa, kodwa "yenza okungakumbi" kunokuba unyango olunyanzelisayo kuba luyilwe ukwenza okungakumbi kunokuba luncedo iimpawu zodwa - injongo yalo kukunyusa ubomi kunye nomgangatho wobomi ngexesha lokuphila.

Yisetyenziswe nini?

Ukuchaza unyango lwemiphunga yomdlavuza wamaphaphu ngaphezulu, kukusetyenziswa kwemichiza emva kokuba umntu uphathwe ngemigangatho emine ye -chemotherapy ehamba phambili "yokuqala" (isigaba IIIA kunye nesigaba IV) umhlaza wemiphunga ukuba umhlaza awuzange uphumelele ngeli xesha lokuqala -nkonyango. Nangona ebudlulileyo, abantu abazange baphathwe ngokuqhubekayo kweli nqanaba (kwaye endaweni yoko bekulandelwa lixesha " lokulinda elindile " - oko kukuthi, iimpawu zokubeka esweni kunye neengcali ze-radiology ukubona ukuba umhlaza uza kukhula), unyango lokulondolozwa luyilwe ukunceda ngeempawu zesifo somhlaza, kwaye, sinethemba lokuphucula ixesha lokuphila ngaphaya kwelo libonelelwe nge-chemotherapy yokuqala.

Kukho iingxabano ezinxulumene nokusetyenziswa kwonyango. Njengoko naluphina unyango, iimiphumo zempatho zonyango kufuneka zilinganiswe nayiphi na inzuzo. Kwaye-nakwi-economic actuals-iindleko zikwaqwalaselwa kwakhona. Amachiza awenzelwe "ukugcinwa" angabiza kakhulu. Olunye uphando lubonisa ukuphuculwa kancinci kakhulu ekusindeni (umcimbi weentsuku ukuya kwiiveki kuninzi), kunye neentsapho zihlala zihlala zijongene nokuphucula kakhulu ukunyamekela kunye nomthwalo wemali unyango.

Ziyiphi Imithi Eyasetyenziswa?

Okwangoku, kukho amayeza emibini avunywe yi-FDA yokulungisa unyango lomhlaza wamaphaphu.

Amanye amachiza amaninzi (kunye nokuhlanganiswa kwamachiza) afundwa kwizilingo zeklinikhi . Iziyobisi ezivunyiweyo ziquka:

I-Alimta (pemetrexed) - Ngo-2009, i-FDA ivume ukusetyenziswa kwe-Alimta kwonyango lokulondoloza umdlavuza wamaphaphu.
I-Tarceva (erlotinib) - I-FDA ivumile iTarceva ukuba isebenzise njengonyango lokulondoloza umdlavuza wemiphunga ngo-2010.

Ngubani ozuza kakhulu kunene?

Njengokuba kuninzi unyango lomdlavuza wamaphaphu, kukho abantu abathile abaphendulisa ngakumbi kunokuba abanye baye kunyango.

Izifundo kunye no-Alimta ziye zabonisa ukuba kubonakala kusebenza ngakumbi kubantu abanomphunga adenocarcinoma kunye nomdlavuza omkhulu wamangqamuzana. Kwakhona kubonakala kusebenza ngakumbi kubantu abanokuguqulwa kwe-EGFR .

Izifundo kunye neTarceva zibonisa nokuphila okuphuculweyo ngokuyinhloko kubantu abanomdlavuza ongasetyenzana wesifo samangqamuzana angenayo isifo somhlaza wesifo somhlaza. Kwakhona kubonakala kunceda abantu abane-EGFR ukuguqulwa kwezinga eliphezulu kunezo ezingenalo utshintsho. Inzuzo enkulu yokusindisa unyango kunye neTarceva yafunyanwa ngabasetyhini abangabhiyozeli bezempilo abasemgangathweni ngenye indlela ngexesha labo kunyango.

Iziphumo eziPhakathi kunye neengxaki

Ulwaphulo lweZonyango kwiNcinci yeSifo seLung Cancer Extensive Stage

Nangona i -rapy yokongamela isetyenziselwa kakhulu umhlaza wesifo samangqamuzana omnxeba, iimvavanyo zonyango zangoku zibonisa ukuba kukho inxaxheba kwinqanaba elincinci lomhlaza wesifo somnxeba ngaphantsi komgca, ngesimo sokufikelela ekuphuculeni okubonakalayo kubantu abaphathwa ngokulondolozwa kwelanga kunye neprophylactic cranial i irradiation.

Inkxaso kunye nokuKhekana

Kuthiwayo ukuba enye "yeempembelelo" zonyango lokulondolozwa kukuba abantu abafumani ngoluvo lokuba baphumelele unyango. Ngamanye amagama, abavakalelwa ngathi "basinda." Kunokukunceda ukugcina engqondweni ukuba unyango lwe-hormones olunyango lwebele lwebele lubonwa ngonyango lwonyango ngokunjalo, kwaye uninzi lwabantu abanomdlavuza webele luqhubeka nokuthatha unyango lwe-hormonal, okanye i-tamoxifen okanye i-inhibitor ye-aromatase xa begqibe unyango lomhlaza . Kungasinceda sikhumbuze sonke inkcazo yomhlaza osindileyo: umntu unomdlavuza osesikweni xa befumanisa ukuba banesifo, kunye nobomi babo bonke.

Kungenzeka ukuba unyango lomhlaza wesifo samaphaphu luya kunyuka kubini inani labantu abasebenzisa le nyango kunye nokubaluleka kwayo. Ingqiqo kukuba siqala ukunyanga umdlavuza wamaphaphu ngaphezulu nangakumbi njengesifo esingapheliyo . Asikwazi ukuphilisa abantu abaninzi, kodwa isifo sinethemba lokulawulwa ixesha elide.

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Uphi unyango lweSondlo?

Iinjongo zoLondolozo lweNyango

Yisetyenziswe nini?

Ziyiphi Imithi Eyasetyenziswa?

Ngubani ozuza kakhulu kunene?

Iziphumo eziPhakathi kunye neengxaki

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