Imizimba yethu ine-hormones elawula zonke iinkalo ze-metabolism, kwaye iquka ukutya kunye nesisindo somthetho. Kuye kwafunyanwa amahomoni amaninzi achaphazela ukutya kunye nokukhuselwa okanye ukuthintela ukukhuluphala . Kukho ezine ezine-hormone ezinje: i- ghrelin , i-leptin, i-insulin kunye ne-Peptide YY (PYY). Eli nqaku ligxile kwi-leptin.
Iyini iLeptin?
Ngokuthi nje, i-leptin yimi hormone ephazamisa ukutya.
Kuye kuthiwa "yinto ephilileyo" kwesi sizathu. I-Leptin iveliswa ngama-adipose (amanqatha) iiseli. Ngoko izinga lemveliso yalo lilingana namafutha omzimba. Xa amanqanaba omnxeba enyukayo, ngokunjalo ngaba amanqanaba e-leptin, asebenzayo ekunciphiseni isondlo kunye nokwandisa izinga lokunciphisa umzimba. Xa amafutha omzimba ewa, kunjalo na amanqanaba e-leptin, kunye nokuxinwa kwesondlo kususwe, ukubonakalisa emzimbeni ukuba ixesha lokutya kwakhona. Ekuqaleni, oku kwasebenza ngenjongo yokuthintela indlala.
Ngezinye izihlandlo iLeptin ithathwa ngokuba ngumlingani weghrelin ngenxa yokuba i- ghrelin (enye i-hormone elawulayo yondlo, eveliswa yisisu kunye ne-duodenum) ivuselela isantya njengoko amanqanaba ayo ephakama. Ngenxa yokuba i-leptin inokunciphisa ukungenisa ukutya ngokunciphisa ukutya, kunokunyusa ukulahlekelwa kwesisindo; ukuphikisana nalokho, kuba i-ghrelin inokunyusa ukudla ngokunyusa ukutya, inokubangela ukuzuza ubunzima kunye nokukhuluphala.
Ngowe-1994, i-gene evelisa i-leptin, eyaziwa ngokuba ngumfuzo womntu ( OB ), yafumaniswa nguZhang kunye noogxa kwiinkonzo.
I-Leptin ibikwa ukuba inezinto ezininzi ze-biological, ezibandakanya iimpendulo zomzimba kunye nokuvuvukala, indima ekuqaliseni ukukhulelwa komntu, indima ekuvelweni kwethambo, kunye nendima ekuphilisweni kwelinxeba, phakathi kwabanye kunye nangaphezulu kwendima yayo kummiselo wesisindo.
Yintoni echaphazela amazinga eLeptin?
Abaphandi baye bafumanisa ezininzi iindlela zokuziphatha kunye nezinto ezinokunyusa okanye ukunciphisa amanqanaba e-leptin emzimbeni.
Ubungakanani kunye nokudla kwexesha kubonakala kubamba indima ekukhutsheni i-leptin ukusuka kwimizimba ye-adipose. Ukongeza, ukubunjwa kwesidlo kubalulekile. Kwezinye izifundo, umzekelo, ukutya okunamafutha athile kubonakala kubangele amazinga aphezulu okujikeleza i-leptin kunokutya okutyebileyo. Kukho ubungqina bokuba izigulane ezigqithiseleyo ziye zaba yi-leptin-resistant, okanye zichasene nemiphumo ye-leptin, ngoko ke indlela evamile yokulawula i-biological exelela umzimba xa ixesha lokuyeka ukutya liphazamiseke.
Ukulala okuncinci kunokuchaphazela amanqanaba e-leptin, okubangelwa amanqanaba aphantsi kunye nesondlo esikhulu (esebenza kwikhonsathi kunye ne-ghrelin, njengoko kuchaziwe ngasentla). Ukufumana iiyure ezisixhenxe ezithandwayo zobuthongo obungaphazamisekiyo ubusuku bonke kubonakala kunceda ukugcina amazinga e-leptin apho kufuneka abe khona ekuphenduleni ukutya.
Njengoko kunokucatshangelwa, ngenxa yokukwazi ukunyusa ukulahleka kwezinto, uphando olujongene nezindlela ezahlukeneyo zokusebenzisa i-leptin kunye nemisebenzi yalo yezokwelapha i-pharmacologic iye yaqhubeka ixesha elithile kwaye liyingxenye yokufuna ukuqhubela phambili ukuphulukana nokuphulukana nokugqithisileyo.
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