I-MS Infrappm Drug, kodwa ikhona Imibuzo emininzi
Nangona kungekho nonyango kwi- multiple sclerosis (MS) , kukho imishanguzo enokukunceda ukuthoba isifo-ezi zonyango zibizwa ngokuthi unyango oluguqula izifo . Ukongezelela, kukho iindlela zokuphucula iimpawu kunye nokuphucula ngokwenene umgangatho wobomi bomntu kunye nokusebenza.
Esinye isifo se-MS-isilumkiso esiluphuculayo mhlawumbi uvile nge-cannabis, eyaziwa nangokuthi i-marijuana.
Masiqwalasele ngokuthe kratya inxaxheba ephambili ye-marijuana e-MS, kunye nokuphikisana okubandakanya le nkunkuma eyaziwayo.
Indima yeManjuana ekuThatheni iSpasticity kwi-MS
I-Marijuana sele isetyenzisiwe kwi-MS ukukhupha ukuxhamla , okuyiyo impawu ebuthathaka kunye neyobuhlungu echaphazelekayo echaphazela i-sibini kwisithathu sabantu abane-MS.
Ukusabalalisa kubhekiselele ekutheni ithoni ye-muscle eyandisiweyo, oku kuthetha ukuba imisipha ethile (ingakumbi leyo kwimilenze) inzima ukuphumla. Ukuxhalabisa kunokuba nzima, kubangele ubuhlungu besisu kunye nokuqina, ukuphazamisa ukuhamba okanye ezinye izinto, kwaye kukhokelela ekuwa.
Ngelishwa, imishanguzo yendabuko esetyenziselwa ukuphatheka kakubi kwi-MS (umzekelo, i-muscle relaxants, i-benzodiazepines, okanye i-anticonvulsants) kaninzi ayisebenzi kakuhle kwaye iphethe imiphumo efana nokulala, okungonakalisa ukukhathala okuhlobene ne-MS-i- double whammy. Ngaphezu koko, njengalezi zonyango, iziyobisi ezingekho iziyobisi zokwelapha ukungcola kwi-MS (umzekelo, unyango lwezonyango kunye nonyango lwe-electromagnetic) nalo lufunyenwe luncedo luncinci.
Yingakho oogqirha be-MS baye baphendukela kwizonyango ezinjenge-marijuana ukwenzela ukuba banike izigulane zabo izibonelelo ezifanelekileyo.
Isifundo esisodwa kwiMarjuana ngokuSasazeka kwi-MS
Olunye uphando kwi- Journal ye-Neurology, i-Neurosurgery kunye ne-Psychiatry ihlolisise abathathi-nxaxheba abangama-300 abane-MS. Abathathi-nxaxheba babe nesifo esizinzileyo phambi kweenyanga ezintandathu kwaye baxela ukunyamezela kokunyamezela nokunyamezela ubuncinane ubuncinane kwiinyanga ezintathu ngaphambi kokubhalisa kwisifundo.
Isiqingatha sabathathi-nxaxheba samkela i-cannabis extract (marijuana) kunye nesinye isiqingatha safumana indawo ye-placebo. Abathathi-nxaxheba kunye nabaphandi babengazibonela ukuba ngubani ofumene inambuzane enobuncwane abafumana i-placebo, njengoko izinto zombini zilawulwa nge-captionle ye-gelatine.
Abathathi-nxaxheba bachaza iimpawu ezahlukahlukeneyo, njengeemfasms ze-muscle, kunye nezinga lokuphuculwa phambi kokuba unyango kwaye emva kweeveki ezilishumi elinesibini emva kokuba unyango (okanye i-placebo) luqale.
Ukuxhaswa kwe-muscle stiff emva emva kweiveki ezilishumi elinambini ziphucuke ngokuphindaphindiweyo kabini kwiqela le-marijuana xa kuthelekiswa neqela le-placebo. Kwakhona kukho ukuphucula okuphawulekayo kwimisipha ye-muscle kunye nokuphazamiseka kokulala kulabo bafumene i-marijuana malunga nalabo bafumana indawo ye-placebo.
Iziphumo ezimbi
Ngokubhekiselele kwokhuseleko, iziphumo ezimbi ziphezulu kwiqela le-cannabis lokukhipha kuneqela le-placebo, kunye nezinga eliphezulu leempembelelo ezibiweyo ezivela ekupheleni kwesigaba sokunyuka kwesantya se-cannabis (esasihamba ngokukhawuleza). Oku kwakhokelela ekubeni izinga eliphezulu lokuhoxiswa kweso sifundo.
Ezinye zeempembelelo ezibonakalayo kumgangatho ophezulu kwiqela le-marijuana versus groupbo zibandakanya:
- Utywala
- Ukukhathala
- Umlomo omile
- Ubuthathaka
Oko kwathiwa, ininzi yemiphumo emibi yayimnene okanye iphakathi kwaye iyancitshiswa kakhulu ekupheleni kwesifundo.
ISifundo sesiBili kwiMarijuana Ukusetyenziswa kwe-Spasticity kwi-MS
Kwesinye isifundo, abantu abane-MS ehamba phambili abangenakuphucula imithi yendabuko baphathwa ngo-Sativex (nabiximol), umlomo oqulethe i-tetrahydrocannabinol (THC) kunye ne-cannabidiol (i-CBD), ngeqondo ngalinye le-Sativex ehambisa i-THC kunye I-CBD kumlinganiselo osondeleyo we-1: 1.
Njengengcambu, i-marijuana ivela kwisityalo se-hemp Cannabis sativa, equle i-cannabinoids engamashumi amathandathu okanye ngaphezulu. Kule mihla yokutya, iimbini ezininzi ziyi-THC kunye ne-CBD, ezo zombini ziyakunceda ukukhulula ukungabi nantlupheko ngokunciphisa intlungu kunye nezihlunu eziphumayo.
Abathathi-nxaxheba baqala ukuvavanywa kweveki ezi-4 ze-spray, kwaye ukuba baphumelele kwipesenti ezingama-20 okanye uphuculo olungakumbi kwi-spasticity yabo, baqhubela isilingo seveki ezili-12. Kulo vavanyo lesibini, abathathi-nxaxheba babenomsebenzi wokufumana i-nabiximol okanye i-placebo.
Iziphumo zophando zibonise ukuba abo bafumene i-nabiximol babenokuphuculwe ngokukhawuleza kwintlupheko (kuchazwe ubuncinane ukuphuculwa kweepesenti ezingama-30 ukusuka kwinqanaba lawo) kunokuba iqela le-placebo. Kwakhona kwakukho ukuphuculwa kwimizila ye-spasm kunye nokuphazamiseka kokulala kwindawo yokwelapha ngokumelene neqela le-placebo.
Iziphumo ezimbi
Kuyafaneleka ukuba uqaphele ukuba ngababathathi-124 abaye bathubela kwi-12 yeveki yokuvavanywa kwaye banikwe i-nabiximol, kwakukho kuphela aba-15 abaye baphuma ekufundeni (ipesenti ephantsi kakhulu kunokwaluhlolisiswa apha ngasentla). Oku kungenxa yokuba i-regimen ye-titration ye-dose (ithetha ukuba ngokukhawuleza i-dose yegunju yanda kangakanani) yayicotha kwaye ilumkile.
Ngokufanayo, kwakukho izinga eliphantsi leempembelelo ezichazwe kulolu cwaningo-enye ibhonasi. Kulabo bathatha i-nabiximol, imiphumo eyingozi kakhulu yile:
- Vertigo
- Ukukhathala
- Iimfucu zamathambo
- Usulelo lwe-Urinary tract
Umyalezo osuka ekhaya ovela kulolu cwaningo kukuba inambuzane (kumntu ofanelekileyo, ngoko "ixesha elivivinywe leveki le-4") libonakala lixhamle, likhuselekile, kwaye linyamezeleke kwixesha elifutshane lokwenza unyango lwe-sclerosis.
Ziziphi iInkonzo zoLuntu ezizithethayo
UMbutho weSizwe we-MS uxhasa amalungelo abantu ukuba basebenze kunye nodokotela wabo we-MS ukuba athole inambuzane enenjongo yokwelapha, "ngokuhambelana nemimiselo esemthethweni kulawo mazwe apho ukusetyenziswa okunjalo kuye kwavunywa." Ukongezelela koko, iNational MS Society isekela uphando oluhlola iingenelo nezingozi zokusebenzisa inambuzane njengonyango lwe-MS.
Oku kuthi, ngelishwa, uphando malunga nokusetyenziswa kwegciwane ku-MS luvame ukuphazamiseka ngenxa yemimiselo karhulumente, njengoko inambuzane isasemthethweni kumgangatho we-federal.
Ngokutsho kwe-National Society of MS, isiseko sokuba isikhundla sabo kwi-marijuana sisuka kwingxelo ka-2014 eyakhululwa yi-American Academy of Neurology (AAN). Isitatimende se-AAN sinikeza iziphakamiso zokusebenzisa iindlela ezahlukeneyo zonyango kunye neyonyango kwi-MS ngokusekelwe kuviwo lophando.
Ngokubhekiselele kumgogodla, i-AAN ibonisa ukuba i-cannabis yomlomo ichithwe kunye ne-tetrahydrocannabinol (THC) eyenziwe ngokufanelekileyo iyakwenza ukuba kuncitshiswe ukungabi nabuhlungu kunye nentlungu.
Le nkcazo iphinda ibhale ukuba umlomo we-Sativex (naxibimol) usebenza ngokuphandle ekuphuculeni ukunyanyisa, intlungu, kunye nexesha lokuvuthwa; nangona i-Sativex ayifumaneki okwamanje e-United States.
Ngakolunye uhlangothi, ngokwe-AAN, akukho ubungqina obunelulwazi obunokwenzululwazi ukuxhasa inzuzo okanye ukhuseleko lwe-cannabis yokubhema ukunyanga iimpawu ze-MS.
Ekugqibeleni, ingozi yesikhathi eside yokusebenzisa i-mariju ekuphatheni iimpawu ezahlukahlukeneyo kwi-MS ayifumanekanga ngeli xesha ngenxa yeenani lezifundo. Enyanisweni, enye yeyona nkxalabo ephezulu malunga nokusetyenziswa kwexesha lokugqibela kwendoda enomsoco inobungozi bokusebenza kwengqondo, njengememori kunye nokusebenza okusebenzayo.
ILizwi
Ngokusemthethweni ukusetyenziswa kwegogwa kwiimeko ezahlukeneyo zonyango kwiindawo ezingamashumi amabini anesithoba kunye neSithili saseColumbia (kwaye mhlawumbi baninzi endleleni yabo), inani labantu abane-MS abasebenzisa inambuzane ekunciphiseni iimpawu zabo ze-MS kuya kuphakama.
Nangona kunjalo, ukubeka ingcinezelo yesikhova kunye nexesha elide kunye nokuxhamla, kunye nokunciphisa imiba, njengokuba ziziphi iimpawu eziphatheka kakuhle nge-cannabis okanye yiphi imilinganiselo okanye indlela yokulawula eyiyo, sifuna ubungqina obuninzi besayensi.
Kuze kube ngoko, ukuba ucinga ingcambu ngenxa yobuncwane bakho, nceda uqinisekise ukuba uyayisebenzisa phantsi kolawulo lwe- MS wakho udokotela . Ngale ndlela, unako ukwandisa inzuzo yayo kwaye unciphise umphumo wayo ombi. Ngokuqhelekileyo, oku kubandakanya ukucwangcisa i-marijuana kunye necebo lokubamba.
> Imithombo:
> Amatya B, Khan F, La Mantia L, Demetrios M, Wade DT. Ukungenelela kwamanyathelo okwenzululwazi okwenyuka kwi-sclerosis. I-Cochrane Database Syst Rev. 2013 Feb 28; (2): CD009974. i-doi: 10.1002 / 14651858.CD009974.pub2.
> I-MS Society Society. I-Marijuana yonyango (i-Cannabis) FAQ.
> Novotna A et al. I-aativex (®), i-Sativex (®), i-Sativex (®), i-Sativex (®), eneengcali ezongezelelekileyo ezibangelwa yi-sclerosis. Eur J Neurol . 2011 Sep; 18 (9): 1122-31. i-doi: 10.1111 / j.1468-1331.2010.03328.x.
> Rudroff T, Honce JM. I-Cannabis kunye ne-multiple sclerosis-Indlela eya phambili. Front Neurol. 2017; 8: 299.
> Zajicek JP, Hobart JC, Slade A, Barnes D, Mattison PG, iQumrhu loPhando lwe-MUSEC. I-Multiple sclerosis kunye ne-extract of cannabis: iziphumo zetyala le-MUSEC. J Neurol Neurosurg Psychiatry. 2012 Nov; 83 (11): 1125-32. i-doi: 10.1136 / jnnp-2012-302468.