I-foot foot foot syndrome ngelixesha lonyango
I-foot-foot syndrome (i-HFS), eyaziwa nangokuthi i-palmar erythrodysesthesia, iyimpembelelo yecermatological side of some chemotherapy kunye neyeza zonyango. Eyona nto ichaphazela iintende zezandla kunye neengcambu zeenyawo. I-HFS iyenzeka xa ixabiso elincinci lonyango livuza ngaphandle kweepillari kwaye kubangela umonakalo kwizicubu ezibonakalayo. Uninzi lwabantu abane-HFS bavelisa iziphumo ezinobunzima, kodwa abanye banokubangelwa yimiphumo emibi, ukwenza imisebenzi yokuphila imihla ngemihla ibe nzima.
I-Chemotherapy kunye neTraticed Therapy Iziyobisi ezinokuthi zenze i-Hand-Foot Syndrome
I-foot foot syndrome ixhaphake ngokuqhelekileyo kunye neziyobisi Xeloda (capecitabine) *. Ezinye iziyobisi eziyaziwayo ukuba zenze i-foot foot syndrome zibandakanya:
- 5-FU (fluorouracil) *
- I-Cytosar-U (cytarabine)
- I-Adriamycin (doxorubicin) - ukunyuswa okuqhubekayo
- FUDR (floxuridine)
- I-Doxil (liposomal doxorubicin)
- Idamycin (idarubicin)
- Nexavar (Sorafenib)
- Sutent (Sunitinib)
Gcina ukhumbule ukuba akubona bonke abantu abathatha le mithi yecansom baya kuphuhlisa i-foot foot foot syndrome.
* I- Dihydroprimidine dehydrogenase (DPD) - ene-enzyme ehlukeneyo yeendlela eziqhelekileyo-iyinto eqhelekileyo ye-HFS echaphazelekayo kunye neyokhawulezileyo eyenzeka ngokusetyenziswa kwezi zi yobisi. Ngokuqhelekileyo ihamba kunye nesifo sohudo. Phantse ama-5% aseMelika analo ukusilela. Ukuvavanya oko akuyinto eqhelekileyo, kodwa ugqirha wakho unokukwenza ukuba ufuna ukuthatha enye yezi yobisi.
Iimpawu zeSondon-Foot Syndrome
Iimpawu eziqhelekileyo ezihamba ne-foot foot foot syndrome ziquka:
- Ukulinganisa okanye ukuphazamiseka
- Ukutsha
- Ubomvu
- Ukuvuvukala
- Ukunyamezela
Kwiimeko ezinzima zesifo seenyawo zesikhumba, isikhumba sinokuqala ukuhlambalaza okanye ukuvelisa izilonda okanye izilonda. Elomileyo, isikhumba esilungileyo esinokuthi okanye esingasayi kuyenza sinokufumaneka. Oku kunokuchaphazela umgangatho wobomi bomntu, ngakumbi ukukwazi ukuhamba nokusebenzisa izandla zakhe.
Kwizilingo zeklinikhi, malunga ne- 5% ukuya kwi-10% ekhulwini labantu bafumana le miphumo yesifo seenyawo.
Ukulahlekelwa kwamaFingerprint kunye neSynder Syndrome
Ukulahleka kwefingerprint kuye kwadibaniswa nokusetyenziswa kweziyobisi zomhlaza ezenza i-foot foot syndrome . Le ngcamango yecala engacacanga icingelwa ukuba iyahambelana nobude bexesha apho kuthathwa khona izidakamizwa. Ukutshatyalaliswa nokuphunga kwesikhumba ngexesha elidlulileyo kungenza ukuba iziprinta zeminwe zisuswe. Isifo seenyawo zonyawo safumana ingqalelo enkulu yemidiya ngo-2009 xa indoda yaseSingapore ivalelwe kwi-Customs yase-US ngokungenayo iminwe yeminwe. Imeko yakhe yayihlobene nokuthatha i-Xeloda (capecitabine) iminyaka emithathu.
Ukukhusela nokuLawula iSyndndrome Syndrome
Ukuthintela ngundoqo kunye neHFS. Ukufudumala nokuxubana yimiba emibini eyona nto ibuhlungu ngakumbi. Emva kweveki emva kokuba unikezelwe imithi ye-IV, okanye lonke ixesha othabatha umhlaza wesibeleko ngomlomo, kukho iindlela ezinokuthintela ukuba uncede ukukhusela nokulawula i-HFS:
Gwema amanzi atshisayo - Ukubonisa isikhumba emanzini atshisayo ixesha elide (ukuthatha iibhati zokuhlamba kunye nemvula, umzekelo), ukuhlanjululwa kokulahlwa, kunye nokuphumla kwi-tub yokutshisa akukhuthazwa. Ukuthatha isitya esilungileyo okanye esifutshane kukubakho kwiiveki emva kokuba uthathe i-IV ingcamango okanye ngexesha lokuthatha imithi yomlomo.
Iiglavu zerubhagi azikhuseli - zitshisa izandla. Ugqirha wakho unokucetyiswa ukuba ungathathi isitya esitshisayo okanye uhlambe iiyure ezingama-24 phambi kokuba unyango.
Gwema Ukuzivocavoca Nomsebenzi Wemiqulu - Ukuzivocavoca okubeka uxinzelelo oluninzi kunye noxinzelelo kwizandla kunye neenyawo, ezifana ne-aerobics, ukuhamba kwexesha elide, ukugijima, kunye nokunciphisa umzimba (kunye neiglavu), kufuneka kugwenywe. Umsebenzi wezandla ezifana nomyezo kunye nomsebenzi weejdi kufuneka ugwenywe.
Ukugqoka iingubo ezifanelekileyo zokugqoka - Izambatho zokugcoba kunye nezicathulo zingabangela ukungqubuzana, oko kukukhokelela ekwenzeni ukuvuza kwama-capillary. Gqoka izicathulo ezipholileyo kunye neengxube ezithintekayo.
Musa ukuhamba ngeenyawo; iisokisi zekotini okanye i-slippers ezithambileyo zilungile.
Musa ukumbathisa izindandatho - Ukunciphisa ukuxubana, thintela ukugqoka amakhonkco kwiminwe yakho. Izindonga ezingasuswa, njengamacenge omtshato, zingaba ngumthombo weebhaktheriya kunye. Iibhaktheriya zingabanjwa phakathi kwendandatho kunye nomnwe. Ukuthintela ukukhuselwa kunye nokulawula kubaluleke kakhulu ngeHFS ngenxa yobubele besikhumba.
Gcina izandla kunye neenyawo ezipholileyo - Kulo lonke usuku, sebenzisa iipakethe ze-ice okanye upholile ukuphoqa izandla kunye neenyawo. Ukuzifaka emanzini amaxesha ambalwa ngosuku kuya kunceda.
Sebenzisa i-Emollients - Iimvolli zi-moisturizers ezikhethekileyo ezicebisa isikhumba esomileyo, esiqhekekileyo kunye nesicasulayo. Uninzi oogqirha bancomela iimveliso ezinjenge-Aveeno kunye ne-lanolin, i-Lubriderm, i-Udder Cream, i-Bag Balm, ne-Aquaphor. Unokufaka izilwanyana eziliqela ngeentsuku, kodwa qiniseka ukuba ungayicubisi ulusu ngonxinzelelo oluninzi. Ukufaka iisokisi kunye neiglavu emva kwesicelo kuya kunceda ukugcina umswakama.
Hlalani Hlazileyo Uhlambulule - Ukudaka amanzi emzimbeni kubangelwa yesikhumba esomileyo, ngoko kubalulekile ukugcina kakuhle amanzi ngamanzi amaninzi. I-caffeine yimbangela eyaziwayo yokudakalisa amanzi kwaye kufuneka igwenywe.
Indlela Ugqirha Wakho Angayisebenzisa Ngayo Indlela Yokulawula I-Foot-Foot Syndrome
Amatyala amancinci ye-HFS angenakufuna ukungenelela kwezonyango, nje ukubeka iliso ngenyameko kuwe kunye nomongikazi wakho kunye nogqirha. Ukuba uqala ukuphawula nayiphina impawu ye-HFS, shayela unesi okanye wakho ugqirha. Ukuba ufumana i-HFS kwaye uqaphele ukuba kubi kakhulu, kubalulekile ukubiza udokotela wakho ngokukhawuleza.
Iimeko ezincinci kwiimeko ezinzima zesifo sezinyawo eziphazamisa imisebenzi yokuphila kwansuku zonke kuthathwa njengengxaki enzulu yonyango, kwaye iphathwa njengolu hlobo. Ukunciphisa unyango okanye ukunciphisa umyinge kunokufuneka. Iimvavanyo zonyango ze-OTC ezifana ne-ibuprofen zinokucetyiswa ukuba zinciphise intlungu. I-oral oralic corticosteroids inokunceda abanye ngokutshabalala. Isigulana esingekho steroidal sokulwa nezidakamizwa I- Celebrex (celecoxib) ibonakala iyasebenza ngokusekelwe ekuphononongweni kwezifundo.
Amanqanaba aphezulu e vithamini B6 ahlala ecetyiswa kubantu abanokuthi bahlakulele i-HFS okanye sele behlupheke kuyo. I-Oncologists ihlala ikhuthaza ukusetyenziswa kwexesha elifutshane le-50 ukuya kwi-150 mg ye-B6, ephakamileyo kakhulu kuneengcebiso zansuku zonke. Uhlalutyo lwama-meta luka-2015 - ukuphononongwa kweengxelo ezipapashwe kuze kube yimini - zahluleka ukufumanisa ukuba i-vitamin B6 inceda ngokwenene ngeenyawo zonyawo, kodwa abantu abayizibalo kunye nokuba abanye abantu banokuphuculwa kweempawu. Njalo qhagamshelana nogqirha wakho ngaphambi kokuthatha i-vitamin B6 ye-HFS. Ezinye izithako ze-vithamine nezamaminerali zinganciphisa ukusebenza kwe-chemotherapy .
Izifundo ezininzi ziqhutyelwa malunga nokuthintela nokulawulwa kwesifo seenyawo. Inendima ye-nicotin patches, i-henna, kunye ne-vitamin E ziphakathi kwezinto ezininzi ezifundiswa ukukhululeka kwe-HFS.
Imithombo:
I-Hoesly, F., Baker, S., Gunawardane, N., noJ. Cotliar. I-capecitabine-induced-foot foot syndrome yinkimbinkimbi yinkqubo yokubamba i-pseudomonal superinfection eyabangela ukuba i-bacterial sepsis nokufa: ingxelo yecala nokuhlaziywa kweencwadi. IiNqoloba zeDermatology . 2011. 147 (12): 1418-23.
Jo, S., Shin, H., Jo, S. et al. Iprophylactic kunye nefuthe lokunyanga kwe-pyridoxine isongezelelo ekulawuleni i-foot-foot syndrome ngelixesha lonyango: i-meta-analysis. I-Dermatology yeCliniki kunye noVavanyo . 2015. 40 (3): 260-70.
IMakedo, uL., uLima, J., dos Santos, uL., no-A. Sasse. Izicwangciso zokuthintela isifo se-hand-footduced-foot syndrome: ukuphononongwa ngendlela echanekileyo kunye nokuhlaziywa kwemeta yezilingo eziza kulandelwa. Unonophelo loNcedo kwiCancer . 2014. 22 (6): 1585-93.
McLellan, B., Ciardiello, F., Lacouture, M. et al. I-Regorafenib-enxulumene nesigxina se-foot foot foot: isiluleko esisebenzayo malunga nokuxilongwa, ukuthintela kunye nokulawula. Amanqaku e-Oncology . 2015. 26 (10: 2017-26.