I-Lumbrokinase yi-enzyme eyenziwe kwiLumbricus rubellus, uhlobo lweentlobo zomhlaba. Kuthengiswa kwifom yokuncedisa ukutya, kubalwa njenge-enzyme ye-fibrinolytic (into ekhuthaza ukuphulwa kwe-fibrinogen, iprotheni ebandakanyeka ekubunjweni kwegazi lamanzi). Ukuxhaswa nge-lumbrokinase kucingelwa ukuba inikezele ngeenzuzo ezininzi zezempilo, kubandakanya ukuphucula impilo yentliziyo kunye nokuncedisa ekukhuselweni kwesithintelo ngokulwa negazi.
Ukusetyenziswa
Abacebisi bakhombisa ukuba i-lumbrokinase inokunceda ngeemeko zempilo ezilandelayo:
Izinzuzo
Kuze kube ngoku, uphando ngemiphumo yempilo ye-lumbrokinase iyancipha. Sekunjalo, kukho ubungqina bokuba lubonisa isithembiso sokunyangwa kweemeko ezithile. Nanku ukukhangela kwiziphumo ezininzi kwiingeniso ezinokuthi:
1) Impilo Yentliziyo
I-Lumbrokinase inokunceda ekwenzeni unyango lwe-angina, ngokutsho kwiphando lokuqala elipapashwe kwiNcwadi ye-Alternative and Medicine Complementary ngo-2009. Uphando, abaphandi babela abantu abaphakathi kwesibini kunye nesifo sengqondo kunye ne-angina kwinyanga enye yonyango kunye ne-lumbrokinase (ngokungezelela ukunyamekela kwabo). Ngophelo lwesifundo, iimpawu ze-angina zaphuculwe kwizigulane ezilishumi kwezi-10.
Ukongezelela, isifundo sokuqala esashicilelwe kwiphepha leTshayina le- Acta Pharmaceutica Sinica ngo-2006 lafumanisa ukuba i-lumbrokinase inokukhusela impilo yentliziyo.
Kwiimvavanyo kwierats, abalobi beengcali baqaphela ukuba i-lumbrokinase inokukhusela ngokumelene ne-myocardial ischemia (imeko ephawulwe ngokucinywa kweerterotic coronary nokunciphisa ukuhamba kwegazi entliziyweni).
2) Isibetho
Uphando oluphambili lubonisa ukuba i-lumbrokinase inokunceda ukunqanda isifo. Ngophando olwenziwa ngo-2013 kwi- Chinese Medical Journal , umzekelo, abantu abangama-310 bhedlele nge-stroke yesichemiksi (uhlobo lwesifo esiyinto eyenzekayo xa i-artery ebuchoseni ivalwe) yayiphathwa ngonyango oluqhelekileyo okanye unyango oluqhelekileyo kunye neeploneli ze-lumbrokinase enye unyaka.
Ngophelo lwesifundo, iqela elifumana unyango lwe-lumbrokinase lalinemivimbo embalwa yecikemikhi.
Ngophando luka-2008 oluvela kwi- European Journal ye-Pharmacology , iimvavanyo kwiiseli zomntu zithi i-lumbrokinase inokukunceda ukulinda isifo se-cerebral ischemia. (Umqathango ophawulwe ngokungafihleki kwegazi ukuya kwingqondo, i-cerebral ischemia inokunciphisa ingqondo ye-oksijini kwaye ikhokelela ekuphazamiseni.) Uphononongo lufumene ukuba i-lumbrokinase inokulwa ne-cerebral ischemia inxalenye ngokuthintela ukubunjwa kwegazi.
Ukongezelela, isifundo esincinci esikhishwe kwi- Clinical Hemorheology kunye ne-Microcirculation ngo-2000 safumanisa ukuba i-lumbrokinase inokuba luncedo ekunyangeni kwe-infraction (i-stroke ye-ischemic ebangelwa ukwenziwa kwegazi ngaphakathi kwengqondo).
Kuhlolisiso, abantu abangama-31 abane-cerebral infarction baphathwa nge-lumbrokinase, ngelixa ezinye izigulane ezingama-20 zabelwa kwiqela lolawulo. Iziphumo zibonise ukuba i-lumbrokinase inokukunceda ukuphatha i-cerebral infarction ngenxalenye ngokunciphisa i-fibrinogen.
3) Isifo sikashukela
Uphando olusekelwe kwisilwanyana olupapashwe kwiSifo seSifo soTyhubela kunye neCliniki Practice ngo-2013 lubonisa ukuba i-lumbrokinase inokukunceda ukulwa nesifo se-diabetes (isifo sengqondo esibangelwa yinxalenye yokulawulwa kakubi kwesifo sikashukela kunye nengcinezelo yegazi ).
Kwimvavanyo echaphazelekayo neeratstiki, izazinzulu zenza ukuba unyango kunye ne-lumbrokinase luncede ukukhusela isifo se-diabetes (mhlawumbi ngokuchaphazela ezinye i-enzymes ezicinga ukuba zidlala indima ekutshatyalazweni kwentliziyo ehambelana nale meko).
Iimiphumo zangaphandle
Ekubeni izifundo ezimbalwa ziye zavavanya iziphumo ze-lumbrokinase kubantu, ngokukhawuleza ukuxelela ukuba i-lumbrokinase ikhuselekile kwixesha elide okanye eliqhelekileyo lokusetyenziswa. Oomama abakhulelweyo, oomama abanamano, kunye nabantwana akufanele bathathe i-lumbrokinase.
Kwakhona kukho inkxalabo yokuba i-lumbrokinase inokubangela imiphumo emibi, kubandakanywa isicupunu, ukuqhaqha, ukuhanjiswa kwesikhumba, ukukhwabanisa kwesikhumba, kunye nokuphendula.
Ekubeni i-lumbrokinase kuthiwa iphule i-fibrinogen (efunekayo ukwenza i-blood clots), kunokwenzeka ukuba incediso ingaphazamisa inkqubo yokuqhawula ngokuqhelekileyo kwaye iholele ekuphumeni kwegazi.
Abantu abaneemeko ezinxulumene nomngcipheko wokwanda kwegazi kufuneka bangathathi i-lumbrokinase. Akufanele kuthathwe ngaphambi kokuhlinzwa okanye emva kokuhlinzwa. Kwakhona akufanele kuthatyathwe ngamachiza, izongezo zokutya, okanye izityalo ezinefuthe legazi.
Kubalulekile ukugcina engqondweni ukuba izongezelelo azange zivivinywe ukukhusela kunye nezondlo zokutya zikhululekile. Nazi ezinye iingcebiso ekusebenziseni izondlo zokutya ngokukhuselekileyo.
Ngaphantsi
Ngoxa uphando oluphambili lubangel 'umdla, kukho ukungabikho kwezilingo ezinzulu zonyango-uhlobo lophando ofuna ukulufumana ukubeka isisitye esigcwele kwonyango-eqinisekisa le miphumo. Ukuba usacinga ukuwusebenzisa, kubalulekile ukuba udibane nodokotela wakho ukuba axoxe ukuba kulungile kwaye ukhuselekile kuwe kwaye uqikelele i-pros and cons. I-Lumbrokinase ayifanele isetyenziswe endaweni yonyango oluqhelekileyo kwiimeko ezifana ne-angina okanye isifo.
Ukuze uncede ekunciphiseni ingozi yakho yokubetheka, kubalulekile ukulawula uxinzelelo lwegazi kunye ne-cholesterol, landela ukutya okunokulinganisela, usebenzise rhoqo, kwaye ugweme ukutshaya. Ezinye iingcamango zibonisa ukuba abantu abadla itiye eluhlaza, itiye elimnyama, kunye ne-omega-3 fatty acids banokuba nomngcipheko wokuncintwa.
Imithombo:
> Cao YJ, Zhang X, Wang WH, et al. I-agent ye-fibrinogen-depleting agent ye-lumbrokinase yokukhusela i-ischemic stroke: iziphumo ezivela kwimizamo yeklinikhi ehlukeneyo, elandeleleneyo, efana neyodwa. I-Chin Med J (Engl). 2013 Nov; 126 (21): 4060-5.
> Ji H, Wang L, Bi H, et al. Iinkqubo ze-lumbrokinase ekukhuseleni i-cerebral ischemia. Eur J Pharmacol. 2008 uAgasti 20; 590 (1-3): 281-9.
Jin L, Jin H, Zhang G, Xu G. Utshintsho kwi-coagulation kunye nomzimba we-plasminogen activator emva kokunyanga kwe-cerebral infarction ne-lumbrokinase. Clinic Hemorheol Microcirc. 2000; 23 (2-4): 213-8.
I-Kasim M, i-Kiat AA, i-Rohman MS, i-Hanifah Y, i-Kiat H. Ukuphuculwa kwe-myocardial perfusion kwi-angina pectoris ngokusemthethweni nge-lumbrokinase yomlomo: isifundo somqhubi. J Altern Complement Med. 2009 ngoMeyi; 15 (5): 539-44.
Sun H, Ge N, Shao M, Cheng X, Li Y, Li S, uShen J. Lumbrokinase unqanda ukungafihlisi kwesifo sikashukela ngokulawula ukuchithwa kwematrix e-extracellular kwii-rats zesifo sikashukela se-Streptozotocin. Isifo sikashukela Res Clin Pract. Ngo-2013 ngoMeyi; 100 (1): 85-95.
Ukuziphendulela: Ulwazi oluqulethwe kule ndawo lujoliswe kwiinjongo zemfundo kuphela kwaye alithathi indawo yeengcebiso, ukuxilongwa okanye unyango ngumgqirha onelayisenisi. Akunakuthetha ukukhusela zonke iindlela zokulondoloza, ukusebenzisana kwezidakamizwa, iimeko kunye nemiphumo emibi. Kufuneka uncede unyango lwangonyango ngokukhawuleza kuyo nayiphi na imiba yempilo uze ubonane nodokotela wakho ngaphambi kokusebenzisa elinye iyeza okanye wenze utshintsho kwi-regimen yakho.