Izinzuzo zezeMpilo, iziSebenzi, nokunye
I-acetylcysteine i-antioxidant ithengiswe kwifom yokuncedisa. Kwakhona kuthiwa yi-N-Acetyl Cysteine (okanye i-NAC), i-N-acetyl-cysteine iguqulwa ngumzimba kwi-amino acid ebizwa nge-cysteine. Kananjalo, i-cysteine inceda ukuvelisa i-glutathione, i-antioxidant edlala indima ephambili ekulawuleni imisebenzi emininzi yamaselula kwaye inceda ukugcina i- immune system ihlole. Abacebisi bathi ukuthabatha i-N-acetylcysteine supplements kungakhusela kwiinkalo ezahlukeneyo zempilo.
Ukusetyenziswa
Ngenye iyeza, i-N-acetylcysteine ithetha ukunceda ngeemeko ezahlukeneyo.
- bronchitis
- ingxaki yokuphefumula engapheliyo ye-pulmonary (COPD)
- i-cirrhosis
- icystic fibrosis
- cholesterol ephezulu
- HIV kunye noGawulayo
- Isifo sikaLou Gehrig
Ukongezelela, abanye abaxhasayo bathi iN-acetylcysteine inokukunceda ukukhusela umhlaza.
Izinzuzo zezeMpilo
Kuze kube ngoku, inkxaso yenzululwazi yeenzuzo ze-N-acetylcysteine ayikhoyo. Nanku ukhangela ezinye iziphumo zophando eziphambili:
1) iBronchitis engapheliyo
I-N-acetylcysteine inokunceda ukugcina i-bronchitis engapheliyo, ngokutsho kwengxelo ka-2000 kwi- Clinical Therapeutics . Ukujonga idatha ukusuka kwizilingo ezisibhozo zonyango, abalobi beengxelo bafumene ukuba ukusetyenziswa kwexesha elide le-N-acetylcysteine kunokukunceda ukukhusela i-bronchitis engapheliyo kunye neendleko zokunakekelwa kwempilo ezantsi.
Okunye: Izilungiso zeNdalo zeBronchitis
2) Isifo sikashukela
U-N-acetylcysteine unokuncedisa ulawulo lwesifo sikashukela, ucacisa uphando olwenziwa ngo-2006 kwi- Journal of Basic and Clinical Physiology kunye ne-Pharmacology .
Ukubandakanya izigulane ezingama-32 ezine-type 2 zesifo sikashukela kunye nolawulo oluphilileyo lwe-15, uphando lubone ukuba iinyanga ezintathu zonyango kunye ne-N-acetylcysteine zancedisa ukulawula ama-glutathione kwizigulane zesifo sikashukela. Ababhali beengcebiso bathi ukulawulwa kwamanqanaba e- glutathione kunokunceda ukukhusela iingxaki zesifo sikashukela ezilethwa ngumonakalo ongenakucala.
Okunye: IziNyango zeNdalo zesifo sikashukela
3) I-Polycystic Ovary Syndrome
I-N-acetylcysteine inokunceda ukuphatha i-polycystic ovary syndrome (i-PCOS), ngokwe-2007 yophando kwi- Acta Obstetricia et Gynecologica Scandinavica . Ngomjikelezo owodwa wesinye isikhathi, izigulane ezingama-573 ze-PCOS zaphathwa nge-clomiphene citrate (isilwanyana esisetyenziswa ngokuqhelekileyo ukunyusa i-ovulation). Emva koko, i-470 yezi zi gulane zathatha inhlanganisela ye-N-acetylcysteine kunye ne-clomiphene citrate enye yomjikelezo wesini. Iziphumo zokufunda zibonise ukuba iirhafu ze-ovulation zaphucuka kakhulu emva kokunyuselwa kwe-N-acetylcysteine.
Qaphela kwakhona: Izilungiso zemvelo ze-PCOS
4) ICystic Fibrosis
I-Acetylcysteine ingaba nefuthe elincinci kumsebenzi wamaphaphu phakathi kwabantu abane-cystic fibrosis, ngokwe-1999 ingxelo kwi- Acta Paediatrica . Ukukhangela idatha ukusuka kwizifundo ezingama-23, ababhali beengxelo baphetha ukuba akukho ubungqina obaneleyo bokuxhasa ukusetyenziswa kwe-N-Acetylcysteine ekunyangeni kwe-cystic fibrosis. Nangona kunjalo, abalobi beengxelo bathi ukusetyenziswa kwexesha elide le-N-acetylcysteine kunokukhokelela ekuphuculeni komsebenzi wamaphaphu wezilwanyana ze-cystic fibrosis.
5) ICOPD
Kwizigulane ezinesigxina, esisisigxina-esiqatha isifo esiyingozi esingasisigxina se-pulmonary disease (COPD), i-N-acetylcysteine inokunceda ekuphuculeni ukusebenza komzimba.
Uphononongo olwenziwa ngo-2009 kwiphepha le- Chest , izigulane ezingama-24 ze-COPD zithatha i-N-acetylcysteine okanye indawo ye-placebo nganye kwiiveki ezintandathu. Emva kokuthatha ikhefu ezimbini (ukuze kupheliswe i-N-acetylcysteine emzimbeni wabathathi-nxaxheba kwiqela lonyango), abathathi-nxaxheba bathatha ishintshi kwezinye iiveki ezintandathu. Iziphumo zophando zibonise ukuba i-N-acetylcysteine yanceda ukuphucula amanqaku amaninzi yempilo yokuphefumula, njengomthamo wamaphaphu nokunyamezela.
Imijelo
Incinci iyaziwa malunga nokukhuselwa kwexesha elide le-N-acetylcysteine.
I-N-acetylcysteine inokubangela inani lemiphumo emibi, kubandakanywa isicupisi, isifo sohudo kunye nokuhlanza.
Ngaphezu koko, i-N-acetylcysteine inokunyusa amanqanaba akho e-homocysteine (i-amino acid ehlanganiswe nesifo senhliziyo). Ukuba uthatha i-N-acetylcysteine, kubalulekile ukuba amazinga akho ase-homocysteine ahlolwe rhoqo.
Ezinye iziganeko ezimbi zivakaliswe kwizifundo zezilwanyana (ngokuqhelekileyo kumaqondo aphezulu), njengengcinezelo yomshumpulane kunye nokuthinjelwa.
Ukongeza, i-N-acetylcysteine inokusebenzisana neziyobisi ezininzi (kuquka imithi ethile yomsinga wegazi, amayeza anokukhusela isistim somzimba, iziyobisi zamachiza, kunye namayeza aphatha intlungu yesifuba).
Izibonelelo azange zivavanywe ukhuseleko kwaye ngenxa yokuba izongezo zokutya zikhululekile kakhulu, umxholo weemveliso ezithile zingahluka kwizinto ezichaziweyo kwilebula yomkhiqizo. Kwakhona ugcine ukhumbule ukuba ukhuseleko lwezongezelelo kwabasetyhini abakhulelweyo, oomama abangabongikazi, abantwana kunye nalabo abanezifo zonyango okanye abo bathabatha imishanguzo ayilwanga. Unokufumana iingcebiso ezongezelelweyo ekusebenziseni izongezo apha .
UkuSebenzisa IzeMpilo
Ngenxa yokungabikho kokuxhasa uphando, kungekudala ukukhuthaza iN-acetylcysteine nayiphi na imeko. Nangona i-N-acetylcysteine inokubonelela ngezibonelelo ezithile zezempilo, ukuzithobela ingxaki engapheliyo kunye ne-N-acetylcysteine isongezelelo kunokuba nemiphumo emibi yempilo. Ukuba ucinga ukuthatha i-N-acetylcysteine, xela ugqirha ngaphambi kokuba uqale irejimen yakho yokuncedisa.
> Imithombo:
> Badawy A, Isizwe O, Abdelgawad S. "I-N-Acetyl Cysteine kunye neComomphhene Citrate yokukhutshwa kwe-Ovulation kwi-Polycystic Ovary Syndrome. I-Acta Obstet Gynecol Scand. 2007; 86 (2): 218-22.
> Duijvestijn YC, i-Brand PL. Uhlolo olusisiseko lwe-N-Acetylcysteine kwiCystic Fibrosis. Acta Paediatr. NgoJan 1999; 88 (1): 38-41.
> Grandjean EM, uBerthet P, uRuffmann R, uLeuenberger P. "Ukusebenza kwexesha elide le-N-Acetylcysteine kwi-Bronchopulmonary Chronic Disease: i-Meta-Analysis ye-Blind Double-Blind, i-Placebo-Controlled Clinical Trials." Clin Ther. 2000 Feb; 22 (2): 209-21.
> I-Memorial Sloan-Kettering Centre. "N-Acetylcysteine". Ja nuwari 2011.
> I-Ozkilic AC, uCengiz M, u-Ozaydin A, uCobanoglu A, uKanigur G. "Indima ye-N-Acetylcysteine Treatment kwi-Anti-Oxidative Status kwizigulane nge Type IiSabetes Mellitus." J Basic Clinic Physiol Pharmacol. 2006; 17 (4): 245-54.
> I-Stav D, uRaz M. "Impembelelo ye-N-Acetylcysteine kwi-Air Trapping kwi-COPD: Isifundo esiLawulayo sePawulo. Esifubeni. 2009 Aug; 136 (2): 381-6.
> IYunivesithi yaseMary Medical Centre. "Cysteine"