Izinto ezili-8 eziphakamisa i-Platelet Count

Ngokuqhelekileyo, isamba seplatelet ngaphezu kwama-450,000 iseli nganye nge-microliter ithathwa njengophakamileyo; Oku kwaziwa ngokuba yi-thrombocytosis. Kukho izimbangela ezininzi ze-thrombocytosis kwaye ngenhlanhla, uninzi luyingozi kwaye ludlulileyo. Makhe sihlole ezinye zezizathu eziqhelekileyo.

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Iingxaki ze-Myleoproliferative

Izifo ezingapheliyo ze-myleoproliferative (ingxaki apho umongo wethambo wenza amangqamuzana egazi amaninzi) kunokubangela i-thrombocytosis. Ezi ziquka i- polycythemia vera , i-thrombocythemia (ET) ebalulekileyo, kunye ne-myelofibrosis ephambili.

E-ET, umzekelo, umongo wethambo wenza ama-megakaryocyte amaninzi, iiseli ezenza iplatelets, ezibangelwa kukuthinteka kwe-thrombocytosis. Ngale miqathango, inani eligqithisileyo leeplatelets lenza ukuba igazi libe likhulu kwaye liqhubeke ngokuthe ngcembe kwaye lingaba negalelo legazi. Utyando lujoliswe ekunciphiseni inani leplatelet ukunciphisa umngcipheko.

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Sulelo

Kuzo zombini abantwana kunye nabantu abadala, ukusuleleka kubangelwa yizona zizathu eziqhelekileyo zokubala kweplatelet ephakamileyo. Olu phawu lunokuba lukhulu kakhulu, kunye neplatelet lubalwa ngaphezulu kwesigidi seseli nganye nge-microliter.

Uninzi lwabantu abafumana le nto luyinto engabonakaliyo kodwa iqela elincinane lezigulane ezinomnye umngcipheko ungavelisa ama-clots egazi. I-Platelet ibalwa ngokuphindaphindiweyo iya kubuya emva kokusombulula isifo, kodwa oku kungathatha iiveki ezimbalwa. Kwezinye izigulane, i-thrombocytosis inokuba yimpembelelo emva kokuba ne-thrombocytopenia (iiplatelet ezisezantsi) ngexesha losulelo losulelo.

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Ukunqongophala kwe-Iron anemia

Nangona i-hemoglobin ephantsi kunye neeseli ezibomvu zegazi yizona zixabiso eziqhelekileyo zebhoratri ezihambelana nokunqongophala kwe-anemia, ukuphakama kwamanani eplatelet akuqhelekanga. Ngeli xesha, awaziwa ukuba yintoni eyenza le thrombocytosis. Ngokuqhelekileyo, iyakunyamezeleka kwaye iyanquma ngokunyanga okufanelekileyo kwonyango.

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Ukungabi nePleen

Inani elithile lamaplatelets lihlala kwindawo yethu kwiphina. Ukuba ipenki isuswe ngokugqithisileyo (splenectomy) okanye iyeke ukusebenza kakuhle (isebenza njenge-asplenia) njengesifo segciwane lesigane, iziphumo ze-thrombocytosis. Le thrombocytosis idla ngokumnene ukuya ekumodareyithini kunye nokunyamezela.

Ngokukhawuleza emva kwe-splenectomy, i-thrombocytosis ingaba nzima kwaye ingabangela ukubunjwa kwegazi. Le nkxalabo ye-post-splenectomy ivela malunga neepesenti ezingama-5 zezigulane. Ngokuqhelekileyo, umngcipheko ngowona mkhulu emva kwenyanga emva kwe-splenectomy.

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Izimo ezivuthayo

Iimeko kunye nokuvuvukala njengengxaki ye-rheumatologic, izifo zesibindi ezivuthayo, kunye ne-vasculitides zinokuthi zine-thrombocytosis. Inani eliphakamileyo leplatelet lwenzeka ngokuphendula kuma- cytokines (iiprotheni ezincinane ezikhishwe kwiiseli ezibonisa ezinye iiseli ukwenza okuthile). Ngokukodwa, ii-cytokines interleukin-6 kunye ne-thrombopoietin zikhuthaza ukuveliswa kweplatelet.

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Cryoglobulinemia

I-cryoglobulinemia edibeneyo ingabangela ukuphakama kwamanga kwi-platelet count. Kule meko, i-cryoglobulins (iiprotheni) egazini inamathelana xa ibonakaliswe kumaqondo abandayo (njengezandla kunye neenyawo). Ezi ngqungquthela zingabalwa ngokukhohlisa njengeiplatelets ngomshini owenza igazi elipheleleyo . Le meko ihambelana nokusuleleka kwe-hepatitis C, i-systemic lupus erythematosus, kunye ne-rheumatoid arthritis.

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Hemolytic Anemia

Ukuba i-hemolytic anemia (i-anemia yesibini kwinqanaba legazi elibomvu) liphumela ekubunzeni iiseli zegazi ezibomvu kakhulu, la maseli egazi abomvu angabiwa ngokuchanekileyo njengeiplatelets ngomshini owenza inani elipheleleyo legazi. Oku kuya kufunyaniswa ngokuphonononga igazi le-smear ye-peripheral (ididescope slide yegazi). Inani elibonakalayo leeplatelets liza kuba lincinci kunye neeseli ezincinci zegazi ezibomvu zibonwe.

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Malignancy

I-Thrombocytosis ingaba nomphumo wesibini wezinye izigulane (umhlaza). Oku kwaziwa ngokuba yi-paraneoplastic thrombocytosis. Oku kuqhelekileyo kwiiswini ezinjengeomdlavuza wamaphaphu, i-hepatocellular (isibindi) i-carcinoma, umdlavuza we-ovari, kunye nomhlaza omnyama. Inani eliphakamileyo leplatelet linokubonakala kwi- leukemia engapheliyo (i-CML) .