Nangona kungekho nonyango kwisifo se-Parkinson , kukho inani lamachiza afumanekayo ukunceda ukulawula iimpawu zesi sifo esiqhubekayo.
Isetyenzisiwe yedwa okanye (ngaphezulu) ngokudibeneyo, la machiza avumela umzimba wakho ukuba usebenze kangcono, oko kukunceda wenze izinto ofuna okanye kufuneka uzenze.
Abantu abane-Parkinson banganceda ngokufunda malunga nendlela asebenza ngayo amayeza, ziziphi iingenelo ezinokubanika zona, kwaye ziphi na iziphumo ezibi ezingabangela. Emva koko, xa ugqirha wakho ebonisa utshintsho okanye ukongeza kwizilwanyana ozithathayo, unokwenza isigqibo esinolwazi kunyango lwakho.
I-Dopamine Alternative Therapy
I-Levodopa , okanye i-L-dopa njengoko iyaziwa ngokuqhelekileyo, ithathwa njengesicatshulwa somgangatho wegolide kwisifo se-Parkinson kwaye iyona myeza esetyenziswa ngokuqhelekileyo kwimeko.
Isilwanyana siguqulwa sibe yi-neurotransmitter dopamine ebuchosheni, obuzalisa iimpahla ze-dopamine ezilahlekile njengoko eso sifo siqhubeka. Ngokwenza njalo, uL-dopa uphucula iimpawu zesifo se-Parkinson.
I-Dopa iyasebenza kodwa ingabangela ezinye iziphumo ezintle, kuquka ukunyakaza okungazibandakanyi (okubizwa ngokuba yi-dyskinesias). Ngokuqhelekileyo ibhalwe ngokubambisana nesinye isiyobisi esibizwa ngokuba yi-carbidopa eyanciphisa loo miphumo.
Dopamine Agonists
Iyeza ezimbini ezisetyenziswa kakhulu kwizifo ze-Parkinson ziyizidakamizwa ezibizwa ngokuba yi-dopamine agonists. Endaweni yokutshintsha i-dopamine kwingqondo yakho, ezi ziyobisi zikhohlisa ingqondo yakho ekucingeni ukuba ine-dopamine eyaneleyo. Amachiza akwenza oku ngokubophelela kwizifunyenwe ezibhekiselele kwi-dopamine kwingqondo.
I-dopamine agonists iyanceda ekunciphiseni iimpawu zesifo se-Parkinson. Zingasetyenziselwa zodwa okanye zidibene neL-dopa.
Iziphumo eziqhelekileyo ezichaphazelekayo ze-dopamine i-agonists ziquka ukuncwina, ukuhlanza kunye nokuhla kwegazi. Abanye abantu banokuzihlakulela ukuziphatha okunyanzelisayo, xa bethatha la mayeza, anokunciphisa ukusebenzisa kwabo.
I-MAO-B Inhibitors
I-Monoamine oxidase inhibitors - eyaziwa ngokuba yi-MAO-B inhibitors - yokuqala isetyenziselwa unyango lokudakumba, kodwa iyanceda ekuphatheni isifo sika-Parkinson. Iziyobisi zithintela ukuphazamiseka komzimba wakho we-neurotransmitter dopamine kwingqondo yakho, enceda ukugcina i-dopamine iphakamileyo kunye nokunciphisa iimpawu zakho ze-Parkinson.
Ama-inhibitors ase-MAO-B asetyenziswa rhoqo kwi-Parkinson abandakanya i-Eldepryl ne-Zelapar (selegiline) kunye no-Azilect (rasagiline). Banokumiselwa yodwa okanye nezinye iziyobisi zikaParkinson, kunye nemiphumo engamaphepha ingabandakanya isicupunu, intloko, umlomo owomileyo, utywaba, ukungazinzi nokulahlekelwa ngumdla.
Abaphandi baye bajonga ukuba i-MAO-B inhibitors ngokwenene inganciphisa ukunyuka kwesifo se-Parkinson (kunokuba nje kuphuculwe iimpawu), kodwa kuphelile ukuba akukho bungqina bokuba. Nangona kunjalo, iziyobisi zinceda ukunyanga iimpawu zikaParkinson.
Kaninzi
Amanye amayeza
Kukho amanye amachiza asetshenziswe kwinqaba yokufumana ukulingana okugqibeleleyo kweemveliso zamachiza kunye nemiphumo emibi yecala.
Iqela lemithi ebizwa ngokuba yi-COMT inhibitors, ngokomzekelo, lunokunceda ngakumbi uL-dopa afinyelele ebuchosheni ngokukhusela umzimba ukuba ungayiphuli. I-Comtan (i-entacapone) kunye no-Tasmar (i-tolcapone) yimimiselo emibili ye-COMT inhibitors.
I-Symmetrel (i-amantadine) isebenza ngokunyusa inani le-dopamine eyenziwa ngumzimba wakho nokukhusela umzimba wakho ukuba ungaphuli i-dopamine ekhoyo. Isetyenziswe ekuqaleni kwe-Parkinson ukunyanga iimpawu, kwaye sinokukunceda ekuhambeni okungazibandakanya kwi-L-dopa.
I-Anticholinergics efana neCogentin (benztropine) ayidla ngokuqhelekileyo kodwa inokunceda izigulane zasePasinson ezincinci zilawula ukugubha. Bajolise kwenye i-neurotransmitter kwingqondo-acetylcholine.
Ekugqibeleni, i-Exelon (rivastigmine), isilwanyana se-drug classic cholinesterase inhibitors, ivunyiwe ukunyanga kwengqondo kwi-Parkinson. Inokukunceda ukuphucula imemori yakho kunye nokusebenza kwakho kwansuku zonke.