Iingxabano zokuQala i-Levodopa kwangaphambili Vs Kamva kwiZifo zePacinson
I-Dopamine i-neurotransmitter efihliweyo esuka kwi-substantia nigra, ummandla omncinci kwi-brainstor ifowuni ephosayo kwisifo sikaParkinson . Njengamazinga e-dopamine yemvelo ebuchosheni aqala ukuwa, iimpawu zesifo se-Parkinson zivela. Ukuba i-dopamine ithathelwe indawo, ezininzi iimpawu ziphucula.
Omnye unokucinga ukuba ke i-dopamine kufuneka inikwe ngokukhawuleza.
Kukho ezinye iindlela, nangona kunjalo. Ukongeza kwi-dopamine ngokuthe ngqo (i-drug called carbidopa-levodopa), izigulane zezifo ze-Parkinson zingazuza kwiklasi yeziyobisi ezibizwa ngokuba yi-dopamine agonists. Ezi zeziyobisi ezingenayo i-dopamine kodwa zineempembelelo ezifanayo kwinkqubo yenzwa. Abanye oogqirha baye baphikisana ukuba i-dopamine agonists kufuneka isetyenziswe ngaphambili kweso sifo kwaye izigulane ezisebekhulile kuphela ezinokukhubazeka ngokulinganayo kufuneka zithole i-levodopa.
Iingxabano ze-Levodopa zakuqala Sebenzisa kwiiNgxaki zePasinson
I-Levodopa yile mveliso ephumelele kakhulu ukunyanga iimpawu zikaParkinson. Oko kwathiwa, akukho miphumo emibi.
Esinye sokwesaba kwe-levodopa kusetyenziswa ukuba kungabangela ukunyakaza okugqithisileyo okubizwa ngokuba yi- dyskinesia . Abantu abane-dyskinesia baneentshukumo zokunyakaza ezingaphandle kolawulo lwabo. Nangona kubonakala kungenakunqweneleka, nangona kunjalo, ininzi kunye ne-dyskinesia iyayithanda ukuba i-parkinsonism, kwaye uphando lubonisa ukuba i-dyskinesia ekugqibeleni ayinaso impembelelo kumgangatho wobomi.
Abanye abaphandi bacebise ukuba i-dopamine inokukhawuleza ukukhawulezisa ikhosi yesifo ngelixa igalela iimpawu. Uphando olungaphezulu aluxhase le ngcamango, nangona kunjalo.
Iimpawu ziyakwazi ukuguqulwa ngelixa i-dopamine, nto leyo ithetha ukuba kukho amaxesha emini apho ukuthuthumela, ukunyaniseka, kunye nokuhamba ngokunyamezelayo kulawulwa kakuhle kunabanye.
Ngakolunye uhlangothi, akucaci ukuba indlela ezo ntshintsho zithintela ngayo umgangatho wobomi. Ukongezelela, abantu bezinye iimachiza ezifana ne-dopamine agonists banokugqithisa.
Ezinye iimbambano zokuxhasa ukusetyenziswa kwangaphambili kwe-levodopa zithi ziya kuphucula umgangatho wobomi kusenokwenzeka kwikhosi yezifo, ukubaluleka kokungakhange kunikwe ingqalelo ngokufanelekileyo. I-Levodopa nayo ingabizi kakhulu kunokuba i-dopamine agonists.
Iinkampani zamachiza azinasakhuthaza ukusetyenziswa kwe-levodopa kuba kukho ezininzi iifom zendalo. Ngamanye amazwi, kukho izikhuthazi zemali kwiinkampani zonyango ukukhuthaza ukusetyenziswa kwamanye amayeza anqabileyo kwixesha elidala kwisifo sika-Parkinson, kunokuba athembele kwi-levodopa yexesha elidala, elizame kunye nenyaniso, kwaye oku kunokuchaphazela ukhetho lokumisela oogqirha.
Iingxabano ezibhekiselele kwi-Levodopa yasekuqaleni Sebenzisa kwiiNgxaki zePasinson
Bambalwa abaza kuxubusha malunga nokuphumelela okuphezulu kwe-levodopa, kwaye zonke izigulane zika-Parkinson ziza kufuneka zigcine zifuna le myeza. Kukho iingxoxo ezikholisayo zokuqala ekuqaleni kwikhosi yesifo, nangona kunjalo.
Amachiza kufuneka afakwe kwi-progression yesifo. Ngamanye amazwi, umntu onesifo esifanelekileyo se-Parkinson oqaliswe kwi-levodopa uya kufuna ukuba imithi ikhule ngokunyuka njengoko isifo sabo siba nzima.
Ngokubanzi, i-dopamine's potency iya kuguga emva kweminyaka emithathu. Xa i-levodopa ephezulu ingasayi kulawula iimpawu, yintoni enye ekhoyo ukubuyela kuyo? Ngaphandle kokukhethwa kwamachiza okunamandla, utyando lungaba yindlela yokuphela. Akukuhle ukugcina "isibhamu esikhulu" kamva, xa iimpawu zinzima kakhulu?
Ukongezelela kwimiphumo emibi ye-levodopa esele ixoxwa ngayo, kukho iingxaki ezinokuthi zongezeleleke ezibandakanya ukusebenza komsebenzi wokuqonda, ukugula kwengqondo kunye nokunciphisa ukulawula umgudu. Enyanisweni ke, ukuba ezinye iyeza ezifana ne-dopamine agonists nazo zineempembelelo, ezifana nokuvuvukala, ukungabikho komzimba kunye nemiphumo yengqondo yengqondo, njengomlutha wokugembula.
Ngamafutshane, kutheni ungasebenzisa "i-gun yakho" ekuqaleni, ngokukodwa xa abaphandi abadlulileyo (nokuba ngaba bephikisiwe okokuqala) baye batyhila ukuba isenza eso sifo sibi nakakhulu? Ingakumbi xa ungasebenzisa imishanguzo enokuthi inganciphisa inkqubo yesifo, ngaphezu kokuncedisa iimpawu?
Ngaba zikhona ezinye iindlela zokwelapha kwii-Parkinson's disease?
Enye inketho yayiza kuba ukuqala unyango olunjenge-monoamine oxidase inhibitor. Umzekelo u-rasagiline, obonakala ubonakala luncedo kakhulu xa uqaliswe ekuqaleni. Ezinye iziphumo ziye zacetyiswa ukuba i-rasagiline inganciphisa ukungonakaliswa kwegazi ngokungezelela kwimpawu zokulawula, ezo zifundo ziphikisana kakhulu. Oku kuhambelani ne-dopamine, apho ezinye izifundo zakuqala zicebise ukuba isifo siphumelele kwisiza.
Sombululo:
Ziza kuxolelaniswa njani ezi mbono zimbini? Ekugqibeleni, akukho nanye imithi yonyango ehambelana nawo wonke umntu. Abantu bahlukileyo kwaye badinga imithi ngamanqaku afanelekileyo. Enye indlela enokuthi inokuthi iqale ukuqala ngamachiza afana ne-rasagiline, ilandelwa ngumthamo ophantsi we-levodopa. Njengoko eso sifo siyaqhubeka, i-dopamine agonist ingongezwa, ilandelwe lizinga eliphezulu levodopa. Kodwa ekugqibeleni, indlela efanelekileyo iyakuthatshintsha kokubili ngokusekelwe kwiimfuno ezikhethekileyo zesigulane kunye nokukhetha kukagqirha malunga neyeza ezahlukeneyo.
Imithombo:
Marras C, Lang A, Krahn M, Tomlinson G, Naglie G; Iqela laseParkinson lokuFunda. Umgangatho wobomi ekuqaleni kwesifo sikaParkinson: impembelelo ye-dyskinesias kunye nokuhamba kweemoto. Disv Disord. 2004 Jan; 19 (1): 22-8.
I-Parkkinen L, u-O'Sullivan SS, i-Kuoppamäki M, uColins C, uKallis C, i-Holton JL, i-Williams DR, i-Revesz T, i-Lees AJ. Ngaba i-levodopa ikhawuleza inkqubo ye pathologic kwisifo sengqondo se-Parkinson? Neurology. Ngo-2011 Oktobha 11; 77 (15): 1420-6.
I-Vlaar A, i-Hovestadt A, i-van Laar T, i-Bloem BR.Unyango lwesifo se-Parkinson sokuqala: i-levodopa ibuyiselwa. Pract Neurol. 2011 Juni; 11 (3): 145-52.