Uvavanyo lwe-LDH lunokunceda ugqirha wakho ukuba afune ukuba umdlavuza wakho wesikhumba usasazeke
I-LDH ukuhlolwa kwegazi ekulinganisa inani le-lactate dehydrogenase (LDH), i-enzyme, egazini lakho. I-Chemically, i-LDH isebenza ukuguqula i-pyruvate kunye ne-lactate emzimbeni wakho. Unokuba uqhelana ne-lactate, njengoko yinto eqokelelwa emzimbeni wakho emva kokusebenza nzima kwaye yenza uzive ukhululekile.
Sibanzi
Ngokubanzi, i-LDH ilinganiswa ukukhangela umonakalo wesikhumba kwiindawo ezinjengeentliziyo, isibindi, iinjongo, isisipha somzimba, ubuchopho kunye nemiphunga - zonke ezo, xa zenzakele, ziphakamisa izinga le-LDH egazini lakho.
Ukuba une- melanoma , ugqirha wakho unokusebenzisa olu vavanyo ukukunceda ukuba umhlaza wakho uye wahluthwa okanye wandaza kwizitho ngaphaya kwesikhumba kunye ne- lymph nodes . Iindawo eziqhelekileyo zomhlaza wokuqhuba inkqubela ziqhelekileyo isibindi okanye imiphunga. Nangona i-LDH ayithethi ngqo kwi-melanoma, ingaba luvavanyo oluncedo lokuhlola okanye ukubeka esweni umhlaza wesikhumba emva kokunyangwa kwonyango. I- staging system ye-melanoma nayo isebenzisa iziphumo zolu vavanyo lwe-LDH ukuhlula izigulane ezinegciwane lesigaba se-IV.
U vavanyo lwenziwa njani
Ukumisela amanqanaba akho e-LDH, umniki-nkonzo wakho wezempilo uzakukhipha igazi kwi-vein yakho okanye kwisithende sakho, ngomunwe, inzwane, okanye i-earlobe. Ibhubhoratri iphosa ngokukhawuleza igazi ukuba lihlukanise i-serum, inxalenye yegazi egazini lakho, ukusuka kwiiseli zegazi. Uvavanyo lwe-LDH lwenziwe kwi-serum yakho yegazi.
Ngaphambi kokuba udibene negazi, ugqirha unokucela ukuba uyeke ukuthatha ezinye iziyobisi eziyaziwayo ukuba zichaphazele i-LDH.
Iziyobisi ezinokunyusa i-LDH ziquka utywala, i-anesthetics, i-aspirin, i-clofibrate, i-fluorides, i-mithramycin, i-narcotics kunye ne-procainamide. I-Ascorbic acid, okanye i-vitamin C njengoko iyaziwa ngokuqhelekileyo, inokunciphisa i-LDH yakho.
Ziziphi i ziphumo zovavanyo
Iimpawu eziqhelekileyo ziyahlukahluka ngokuxhomekeke kwiminyaka yakho, ngesondo, kunye nendlela ekhethekileyo esetyenziswe kwibhubhoratri.
Uhlobo oluqhelekileyo lwesithenjwa ngokuqhelekileyo ngu-105 ukuya ku-333 IU / L (iiyunithi zamazwe ngamazwe ngeyure). I-LDH epheleleyo ihlala ihlukaniswe kwiindawo ezinhlanu (ezibizwa ngokuthi i-isoenzymes) - i-LDH-1, i-LDH-2, i-LDH-3, i-LDH-4, ne-LDH-5-ecacileyo kwimimandla ethile yomzimba kwaye iboniswe njengepesenti leleyo.
Inqanaba le-LDH linokuphakanyiswa kwiimeko ezininzi, kungekhona nje nge-melanoma ye-metastatic. Amanqanaba aphakamileyo kunamaxesha aqhelekileyo angabonisa kwakhona:
- ukubetha
- ukuhlaselwa yintliziyo
- iintlobo ezahlukeneyo zegazi
- uxinzelelo lwegazi oluphantsi
- isifo sesibindi (umzekelo, i-hepatitis)
- ukulimala kwemisipha
- i-dystrophic muscular
- pancreatitis
Iziphumo eziphakamileyo zobuxoki zenzeke ukuba i-specimen yegazi iphathwe ngokukhawuleza, igcinwe kumaqondo obushushu, okanye ukuba isampuli yayinzima ukuyiqokelela.
Ziziphi iimpawu zophando
Izifundo eziphambili zibonise ukuba inqanaba eliphezulu le-LDH linokuqikelela ukusinda kwizigulane ezine-melanoma ephezulu. Ngenxa yesi sizathu, i-LDH ifakiwe kwi- system staging 2002 ye-melanoma. Izigulane ezineesigaba se-melanoma kunye ne-LDH ephakamileyo zihlasele kakhulu.
Ngaphandle kokuhlukanisa izigulane ezinegciwane lesigaba se-IV, uvavanyo lwe-LDH aluxeli ngqo okanye lukhuni ngokwaneleyo ukufumana i-melanoma ngaphambi kokuba idibanise i-lymph nodes. Ucwaningo lulandele izigulane ezine-melanoma iminyaka engama-2.5 emva kokuhlinzwa.
Iziphumo zibonisa ukuba izinga le-LDH alingummakishi omhle "kwi-metastasis ye-transit" (isigaba se-IIIC melanoma esasasazeka ngaphaya kwesikhumba sesikhumba kodwa kungekhona kwi-lymph nodes) okanye isasazeka kwii-lymph node zendawo. Kulo vavanyo, uvavanyo lwe-LDH luye lwachonga ngokuchanekileyo i-metastasis ephakathi kwincinci yezigulane. Uvavanyo lwesinye iprotheni yegazi ebizwa ngokuba yi-S-100B ikhulayo njengemakishi engcono kuneLDH kwaye inokubandakanywa kwiistim ezayo.
Ukuba ugqirha wakho ucele uvavanyo lwe-LDH, okanye nokuba ngaba iziphumo zibuya kwaye izinga liphakamileyo, ungakhathazeki. Iqondo eliphezulu le-LDH alithethi ukuba i-melanoma yakho ifumanekile, yinto "yintloko" kuphela ukuba ugqirha wakho uphando malunga nale meko ngakumbi nge- CT, iPET, okanye i-MRI scan okanye i-lymph node biopsy.
Ukuba unemibuzo okanye ixhala malunga nokutolika iziphumo zeemvavanyo ze-LDH, qiniseka ukuba uxoxe nabo nodokotela wakho.
> Imithombo:
> I-Egberts F, i-Hitschler WN, i-Weichenthal M, i-Hauschild A. "Ukubeka iliso kwonyango oluxhamlayo kwiigulane ze-melanoma ezisengozini enkulu: i-lactate dehydrogenase kunye neprotein ze-S-100B njengezibonakaliso zokuphindaphinda" UkuCandwa kweMelanoma 2008.
> Chun YS, Wang Y, Wang DY, et al. Ixabiso leprognostic lama-S100B namanqanaba e-LDH kwizigulane ze-melanoma " J Clin Oncol 2008 26 (Ngomhla wama-20 uMeyi we-Abstr 9002).
> Eggermont AMM. "Ukufikelela kwisiSeko sokuQala kwiNyango yeMelanoma yeMetastoma" J Clin Oncol 2006 24 (29): 4738-45.