I-allergies kwi-Prilosec, Prevacid, Nexium, Aciphex ne-Protonix
I-Proton Pump Inhibitors (i-PPIs) isetyenziswa kakhulu ngamachiza okonyangwa kwesifo se-reflux ye-gastroesophageal (GERD) , isifo sesilonda se-peptic , kunye nokunyangwa kwezifo. Ii-PPIs zenza iipompo ze-asidi kwisisu, ngaloo ndlela zinciphisa ukuveliswa kwe-asidi, kwaye zisebenza kakuhle ekuphatheni izifo ezahlukeneyo zesisu ezinxulumene ne-asidi.
Kukho inani leproton pump inhibitors elikhoyo kwiimarike, kubandakanya omeprazole (Prilosec), esomeprazole (Nexium), pantoprazole (Protonix), rabeprazole (Aciphex) kunye ne-lansoprazole (Prevacid). Ngokuqhelekileyo, ii-PPI ziyimishanguzo ekhuselekileyo kunye nemiphumo emibini. Oku kungenxa yokuba i-omeprazole kunye ne-lansoprazole zifumaneka kwi-counter-counter-ngaphandle komrhumo (njengokuba umhla wale ngxelo ibhaliwe, esomeprazole, pantoprazole, kunye ne-rabeprazole zifumaneka kuphela ngomyalelo).
Ukuxilongwa kwe-allergies kwi-Proton Pump Inhibitors
Ukuphendulwa kwe-allergen kwi-proton pump inhibitors akukodwa ngokuqhelekileyo kodwa kwenzeka. Zininzi zezi mpendulo ziquka i- urticaria , i-asthma, kunye ne- anaphylaxis . Ngokusoloko kunzima ukuchonga i-PPI njengesisombululo sokuphendula ngenxa yokuba ezinye iyeza, kuquka ii-NSAID kunye ne-antibiotics ezifana ne- penicillin , zihlala zinikwe kunye ne-PPIs ukunceda ukukhusela izilonda zesisu okanye ukunyanga izifo ezibangelwa yi- Helicobacter pylori .
Izifundo ezahlukeneyo zenzelwe abantu abaye bafumana impendulo yokuguquka ngenxa yokuthatha i-proton pump inhibitors. Ukuvavanywa kwesikhumba , kubandakanywa iindlela zokubamba kunye ne-intradermal, zenziwe ngokusebenzisa i-PPIs (kunye neminye imichiza eyenziwa ngumntu) okungenzeka ibangele ukusabela.
Ezi mvavanyo zesikhumba zabonakala zi luncedo ekuboneni imbangela yokuphendula okuthe tye, ngakumbi xa iPPI yimbangela. Imingeni yomlomo usebenzisa i-PPP iphambili ibangele iimpawu zempendulo ekukhuseleni xa ukuvavanywa kwesikhumba kwakulungile. Nangona kunjalo, abantu abaneemvavanyo zesikhumba ezimbi babengenako ukunyamezela i-PPI ngokubhekisele kumngeni ngomlomo.
Umnqamlezo ophakathi kweProtton Pump Inhibitors
Ezi zintlanu ezihlukeneyo zeproton pump inhibitors azibandakanyi isakhiwo samakhemiksi esifanayo, esichaza ukuba xa umntu echasene ne-PPI enye, enye okanye ngaphezulu kwezinye ii-PPI inokunyamezela. Izifundo ezenziwe kwi- cross-reactivity ye-proton pump inhibitors ziye zafumanisa ukuba abantu abaxhamla kwi-omeprazole bahlala behlaselwa kwi-pantoprazole (kunye nango-vice versa), kwaye abantu abaxhamla kwi-lansoprazole bavame ukuhlaselwa kwi-rabeprazole (kunye nenye indlela). Ukubuyiswa kwe-cross-reactivity ngenxa yezakhiwo ezifanayo phakathi kwama-PPI athile; Ukungabikho komsebenzi phakathi kwamanye ama-PPI kunokuvumela umntu ukuba angabi nantoni ethile kwi-PPI ethile ukunyamezela enye i-PPI. Ngokomzekelo, abantu abaxhamla kwi-omeprazole okanye i-pantoprazole bahlala bekwazi ukuthatha i-lansoprazole okanye i-rabeprazole, kwaye abo baqhekeza i-lansoprazole okanye i-rabeprazole badla ngokuthatha i-omeprazole okanye i-pantoprazole.
Kubantu abaye bafumana ukusabela okubangelwa yingozi ngenxa yokuthatha iproton pump inhibitor ethile, ukuvavanywa kwesikhumba kunokuba luncedo ekuqinisekiseni ukuxilongwa. Ukuba ukuvavanywa kwesikhumba ku-PPI kulungile, ukuvavanywa kwesikhumba kwi-PPI engeyiyo yokuphambanisa kungenziwa ngenzame yokufumana i-PPI enokunyamezela umntu. Nangona kunjalo, inselele yomlomo, eyenziwa phantsi kolawulo lwezonyango, kufuneka iqhutywe nge-PPI engeyiyo yokuphambanisa (kunye nokuvavanywa kwesikhumba) ukwenzela ukuba kuqinisekiswe ukuba ixhomekeke ngokukhuselekileyo.
Funda kabanzi malunga nokuxilongwa kunye nokunyangwa kwezidakamizwa .
> Imithombo:
> Bonadonna P, et al. Ukunyaniseka kwe-Proton Pump Inhibitors: Ukuchaneka ngokuchaneka kweeNgxaki zesikhumba xa kuthelekiswa novavanyo lwe-Oral Provocation Test. J Allergy Clin Immunol. 2012; 130 (2): 547-9.
> Chang YS. Ukuphendula kwe-Hypersensitivity kuya kwi-Proton Pump Inhibitors. I-Curr Opin Allergy Clinic Immunol. 2012: 12: 348-53.
> Lobera T, et al. Iziganeko ezithoba ze-Omeprazole Allergy. Umnqamlezo ophakathi kweProtton Pump Inhibitors. J Uphanda i-Allergol Clin Clin Immunol. 2009; 19: 57-60.
> Perez Pimiento AJ, et al. Ukunyanzelisa i-Lansoprazole kunye neRabrazole ngokunyamezela kwezinye i-Proton Pump Inhibitors. 2006; 117 (3): 707-8.