I-Myelofibrosis yimeko apho utywala (fibrosis) ifomula emnzini wethambo. Oku kunzima kwenza kube nzima ukuba umongo wakho wenze amathambo egazi ngokuqhelekileyo.
Iimpawu
I-Myelofibrosis ingabangela ukuba kubekho iimpawu. Nangona kunjalo, inokuthi iqokelelwe kumsebenzi wegazi oqhelekileyo owenziwe ngugqirha wakho. Ezinye iimpawu zihambelana nokunciphisa iiseli zegazi ezibomvu (i- anemia ) kunye neeplatelets ( thrombocypenia ), njenge:
- Ukukhathala okanye ukhathala
- Pallor
- Amachaphazi abomvu kwesikhumba esibizwa ngokuba yi-petechiae
- Ukunyuka kwamanani
- Ukuphuma kwegazi
- Ipeni ekhulisiweyo kunye / okanye isibindi - ungabona ubungqina phantsi kweembambo zakho.
- Bony ubuhlungu
- Umkhuhlane okanye ukusulelwa rhoqo
Ngubani Osemngciphekweni
I-Myelofibrosis ngokuqhelekileyo ivela kubantu abangaphezu kweminyaka engama-50. Iyakwenzeka kubantwana kodwa inqabile kakhulu. Izigulane kunye ne-polycythemia vera okanye i-thrombocythemia ebalulekileyo ingaqhubeka nokuphuhlisa imyelofibrosis.
Kutheni Kutheni Ipenti Yakho Yandisa?
I- pleen iyilungu le-hematopoietic, elithetha ukuba linako ukwenza iiseli zegazi. Kwi-myelofibrosis, apho umongo wethambo unobunzima ukwenza amangqamuzana egazi, i-spleen ikhulisa ukuzama ukuphucula imveliso.
Izizathu
I-myelofibrosis yeprayimari yindlela engabonakaliyo yomhlaza wegazi (inxalenye yeengxaki ezingapheliyo ze-myeloproliferative neoplasms). Oku kubangelwa ukuguquka komzimba. Ngeli xesha asiqinisekanga ukuba yintoni eyenza ukuguqulwa kwenzeke.
I-Myelofibrosis ingabangela ezinye iimeko kwaye kuthiwa yi-myelofibrosis yesibini.
Ezi ziquka:
- Amanye amachiza egazi, ingakumbi i-legemiaid leukemia (i -leukemia ephawulekayo ) okanye i-myelodysplastic syndrome
- I-metastasis yesifo somhlaza
- Izifo ezenza ngokuzenzekelayo njenge-lupus, i-scleroderma
- I-pulmonary hypertension: Kule meko, kukho uxinzelelo lwegazi oluphezulu kwimithambo yegazi emiphakeni.
- I-Hyperparathyroidism edibene ne-vitamin D
- I-grey platelet syndrome
- I-oaleodystrophy ye-Renal: Le yintlupheko ye-mineral and bone metabolism eyenzeka kwizigulane ezinezifo ezingasigxina.
Ukuxilongwa
Ekuqaleni, ukubalwa kwegazi kwehla kuchongiwe kwibala elipheleleyo legazi . Ngokuqhelekileyo, i-anemia kunye / okanye i-thrombocytopenia zikhoyo. Umonakalo kwiiseli zegazi ngokuqhelekileyo kuchongwa kwi-blood smear ye-peripheral, i-microdicope slide ye-drop of blood. Iibomvu zegazi ezibomvu zivame ukuchazwa ngathi zibukeka njenge-teardrop.
Ukuxilongwa kokugqibela kufuna i-bone marrow biopsy, inkqubo apho isalathisi esincinci sisuswa khona. Ngamacwecwe akhethekileyo, iifayile ezinobomvu emnzini wethambo zichongiwe.
Ngexesha loxilongo lokusebenza, ugqirha wakho uza kuzama ukuqonda oko kubangela i-myelofibrosis. Kufakwe kulo msebenzi kuya kuba nokuhlolwa kofuzo lwezitshintsho ezithile ezibizwa ngokuba yiJAK2, MPL kunye neCALR.
Unyango
Unyango luxhomekeke kwisizathu esibalulekileyo. Unyango lwe-myelofibrosis oyintloko uzimisele ngengozi yokuqhubela izifo kunye nokuphila ngokubanzi.
- Ukuqwalaselwa: Ukuba ungekho iimpawu ezibalulekileyo, ukulindela okulindelekileyo kunokukhetha ukhetho olungcono.
- Ukutshintshiswa : I-anemia kunye ne-thrombocytopenia ebonwa kwi-myelofibrosis inokuba nzima yaye ingadinga igazi rhoqo. Ukuphindaphindwa kwegazi kunokugqiba ukuba kufuneka unyango olungakumbi.
- Umnxeba we-Bone (i-stem cell) yokutshintshwa: Isigqibo sokutsalwa kufuneka silinganiswe ngenyameko kwiingozi kunye nezibonelelo.
- I-Ruxolitinib: Eli gciwane liyakhusela i-JAK2 linokusetyenziswa kwizigulane ezine-JAK2 zinguqu ezinempawu eziphawulekayo kwaye azivumelekanga ukutshintshwa komongo we-bone.
- I-Splenectomy : Ukuba ipeni ayinciphanga ngobukhulu bonyango, inokuthi isuswe.
- I-Hydroxyurea: I-Hydroxyurea yimithi ye-chemotherapy yomlomo engasetyenziselwa ukunciphisa ubungakanani be-spleen kunye nezinye iimpawu.
- Amanye amayeza afana ne-androgen kunye ne-thalidomide
- Ulwaphulo lwe-radiation lungasetyenziselwa ukunciphisa ubukhulu bepen
Utyando lwe-myelofibrosis yesibini lujoliswe kwisizathu esiyintloko. Ngoko ukuba i-myelofibrosis ibangelwa ngumhlaza njengomhlaza we-lemonemic acute (AML), uphathwa nge-chemotherapy. Ukuba i-myelofibrosis isibini kwisifo esizimele, unyango lwaloo ngxaki lunokuphucula igazi.
Naluphina unyango, iqela lakho lezokwelapha liya kukuhamba ngawo onke amanyathelo okufuneka uwathathe ukuze abe nokulawula impilo yakho. Unganqikazi ukwabelana ngeengcamango, imibuzo kunye nemizwa yakho.