Kutheni Abesifazane Benza Iimeko Zinyameko?
Ukunyuka kwemizi. Ukukhulelwa. Ukunquma kwexesha. Fibromyalgia . Isifo sokunyamezela esingapheliyo . Yintoni abafana ngayo? Bafazi. Ewe, ezintathu zokuqala ziimeko zeemeko kuphela. Kodwa, nangona abantu bebenokuba ne-fibromyalgia (i-FMS) okanye i-chronic fatigue syndrome (i-CFS okanye i- ME / CFS ), abafazi bahlakulela amazinga aphezulu kakhulu.
Kutheni Abafazi Basondele Kakhulu kwi-Fibromyalgia & Syndrome Isifo Sengapheliyo?
Ukufumanisa ukuba kutheni, abaphandi bajonga:
- IHormones
- I-Brain chemistry
- Amasosha omzimba kunye nokuvuvukala
- Genetics
Kwakhona kunokwenzeka ukuba iindibano zesini zesini zidlala indima ekungalingani.
Ulwahlulo lweHormonal
Xa ubheka ukungafani kwesini, kuyacaca ukuba uqale ngamahomoni. I-hormones, efana ne-estrogen kunye ne-testosterone, inokuchaphazela kakhulu inkqubo ye-nervous system, enoxanduva lokubona nokudlulisa intlungu yentlungu, "kusho umchwepheli wolawulo lweentlungu uMark Peckman, WENZA. Ukongeza kwi-FMS kunye ne-ME / CFS, utsho oku kunokukunceda ukucacisa ukuba kutheni abafazi banamathele kwi- osteoarthritis , iintloko kunye nesifo sengqondo segazi .
Uphando lubonisa ukuba i-testosterone, i-hormone yamadoda, inendima ekuthintela ukukhathala kwemisipha. Abaphandi bathi iprotheni ethile isebenza kunye ne testosterone ukulungisa izihlunu emva kokusebenza. Abasetyhini bane-testosterone encinci, ngoko banokuphelelwa kanzima komzimba. Uphononongo luye lwabonisa ukuba amadoda alondolozwe kangcono kwisixhumanisi sezinto eziphilayo phakathi kokukhathala kunye nentlungu.
Olunye uphando lubonise ukungafani kobulili kwi-cortisol yokuxinwa kwe-hormone abaphandi bathi bayaphantsi kwi-FMS kunye ne-ME / CFS. Oko kwenza umzimba ube nomonakalo omkhulu ekukhathazeni, ngokusemzimbeni okanye ngokomzwelo. (Ukuxinzezeleka komzimba kubandakanya ukugula, ukunyamezela, nokuvuka kusasa.)
Kwisifundo se-UCLA esingahambelani ne-FMS kunye ne-ME / CFS, abaphandi bafumanisa ukuba abafazi kwimitshato engonwabileyo bakhululwa ngokukhululeka kwe-cortisol xa kuthelekiswa nabasetyhini abatshatayo. Amanqanaba e-cortisol yamadoda, nangona kunjalo, awanakunxulumene nolwaneliseko lomtshato. Oku kunokukunceda ukuba uchaze ukuba kutheni iimeko ezibonakaliswe yi-cortisol ephantsi ziqhelekileyo kubasetyhini.
I-Gender & Chemistry yobunjineli
Uphando lweSweden luka-2008 luphakamisa ukuba inkqubo yeserotonin yengqondo isebenza ngokuhlukileyo kumadoda nakwabasetyhini. (I-Serotonin yintsholongwane ejongene nentlungu, ukulala, ukuxhalaba kunye nokuxinezeleka, kunye neengcali zithi ziphantsi kwi-FMS ne-ME / CFS.)
Abaphandi babonisa ukuba abafazi ngokwemvelo banama-receptors amaninzi kunye namanqanaba aphantsi eprotheni ehambisa i-serotonin kwiiseli zesisongela ezithumelayo (inkqubo ebizwa ngokuthi iphinda iphindwe).
Zininzi zamachiza eziqhelekileyo ezichazwe kwi-FMS kunye ne-ME / CFS yokunciphisa ukuphindaphinda kwakhona (i-SSRIs kunye ne-SNRIs), kwaye abaphandi bathi oku kunokusinceda siqonde ukuba kutheni amadoda nabasetyhini baphendula ngokungafaniyo nala mayeza. Baphinde bathi iziyobisi kufuneka zivavanywe kwamadoda nabasetyhini ngokwahlukeneyo, kunye nakwabasetyhini kokubili nangemva kokumisa umva.
Uphononongo lubonisa ukungalingani kwenkqubo ye-serotonin phakathi kwabasetyhini abenzayo kwaye abangafumani iimpawu ze-PMS , kungakhathaliseki ukuba yintoni inyanga yenyanga, ebonisa ukuba ubuchopho be-PMS abukhompendulo nakwiimpendulo ze-hormonal.
I-PMS yimeko eqhelekileyo yokuxhatshazwa kunye ne-FMS kunye ne-ME / CFS kwaye ihlala ikhupha iimpawu.
Ucwaningo oluthile lubonisa ukuba amanqanaba ase-serotonin aphantsi achaphazela amadoda kunye nabasetyhini ngokwahlukileyo. Abaphandi bathi bangela ukuba amadoda afuneke ngakumbi kodwa angabangela ukuba ezinye iimeko zitshintshe, ngoxa abafazi babika imiba engakumbi kwaye baqaphela ngakumbi.
I-Immune System, i-Fibromyalgia kunye ne-Chronic Fatigue Syndrome
Abanye besetyhini bafumana iimeko ezikholelwayo, ubuncinane inxalenye, ukubandakanya i-immune system esebenzayo. Ziquka i-FMS, ME / CFS, isifo se-celiac , i-IBS kunye nabanye.
Amaninzi amaninzi e-ME / CFS akholelwa ukuba abangelwa yi-HIV kunye nentsholongwane yomzimba kwisimo esingapheliyo, ngokufana nento wonke umntu ahlangabezana nawo xa umzimba wabo ulwa negciwane.
Ukwahlukana nge ME / CFS, nangona kunjalo, ukuba umzimba awuyeki ukulwa. Abaphandi bathi ezinye iimeko ze-ME / CFS zinokudityaniswa nokusuleleka kwintsholongwane engapheliyo, ngelixa ezinye zibangelwa yi-ntsholongwane eshiya emva kweenguqu zogxininiso kwi-immune system.
"Emva kokuba i-immune system iqhutywe kakhulu, inokuvelisa iikhemikhali ezivuthayo ezenza iintlobo ezininzi zentlungu kunye kunye kunye," kusho uPeckman. Emva koko, ukuvuvukala kunokuchaphazela iimbilini apho zisengozini.
I-Genetics, iGender & Fibromyalgia
Sekudala ukuba iingcali zikholelwa ukuba i- genetic predisposition idlala indima enoba uza kuhlakulela i-FMS okanye i-ME / i-CFS xa ubonakaliswe ngokufanelekileyo (okanye mhlawumbi okungalunganga) kwizinto eziphathekayo, ezinjengokuphazamiseka kokulala, ukusuleleka kwintsholongwane okanye uxinzelelo olubi.
ULaurence Bradley, u-PhD weYunivesithi yase-Alabama eBirmingham ukhangele ukuba ngaba ukuthambekela kofuzo kwi-FMS kukwasekelwe kwisini. Uthi u bungqina bubonisa ukuba ukuphazamiseka kwenzeke ngokuphindaphindiweyo phakathi koodade kunokuba kwenza abazalwana. Ucwaningo lwe-genetics luthatha abazalwana kunye noodade abanempilo yabasetyhini nge-fibromyalgia nokuthelekisa iintlungu zabo kunye neqela lolawulo.
Iqela likaBradley liza kubheka amanqanaba e-serotonin, enethemba lokuqinisekisa ingcamango yokuba abantu abane-FMS banokungaqhelekanga ngokwemizimba elawula ukukhiqizwa kwe-serotonin.
Ukuba ufundiso lukaBradley luqinisekisa ubungqina bokungaqhelekanga, uthi luya kuphucula ukuqonda kwethu kweFMS kwaye lunokunceda ekufumaneni ukuba ngubani osemngciphekweni.
ImiSebenzi yoLuntu ngesini
Ezinye iingcali zicinga ukuba amadoda amaninzi ayesigxina ngeempawu zabo kuba bakholelwa ukuba bathetha ngabo babenza babonakale bebuthathaka. Ngenxa yokuba abaxeleli oogqirha babo ukuba kwenzekani, abanako ukufunyanwa.
Kwakhona, kuba i-FMS kunye ne-ME / CFS idlalwa ngathi "izikhalazo zesibhambathiso," oogqirha abanako ukucinga ngabo ngokufanelekileyo ukufumana izigulane zamadoda.
Imithombo:
2008 I-American Physiological Society. Onke Amalungelo Agciniwe. "Ukhathala komzimba kuqhutyelwa kwindoda kodwa kungekhona i-ASIC3 - / - iigundane"
2008 Elsevier BV Wonke amalungelo agcinwe. "Abasetyhini abaninzi baxinezelekile kwaye amadoda aninzi aphefumulayo kunye nokusebenza kweSerotonin eyanciphisa"
2008 News-Medical.Net. Wonke amalungelo agcinwe. Inkqubo ye-serotonin yeBongo ihluke phakathi kwamadoda nabafazi "
2007 Inkqubo yeMpilo ye-UAB. Onke Amalungelo Agciniwe. "Izifundo eziPhezulu zePain Examination Fibromyalgia"
2008 University of California Regents. Onke Amalungelo Agciniwe. "Kwabesetyhini, ukuxinezeleka komtshato kuthetha ukukhululeka okukhulu ekucindezelekeni"