Ngaba i-Diarrhea kwi-IBS ingaba neengxaki kwi-Bile Acid Malabsorption Problems?
Ekuphandeleni ukuqonda okujongeyo kwezinto ezibangelwa yintsholongwane ekhutshulwayo (IBS), abanye abaphandi baye baqwalasela imeko ebizwa ngokuba yi-idiopathic bile acid malabsorption (I-BAM).
Yintoni i-BAM?
I-bile acids zizinto eziveliswa sisibindi sakho kwaye zigcinwe kwi- gallbladder yakho. I-acid ye-Bile inceda inkqubo yokugaya amafutha, okwenzeka ngaphakathi emathunjini amancinane.
Ngokuqhelekileyo, i-bile acids ibanjwe ngumathumbu omncinci kwaye ibuyele kwisibindi ukuba iphinde iphinde isetyenziswe kwaye isetyenziswe kaninzi ngamaxesha ama-10 ngosuku. Isixa esincinci se-acid acids (iipesenti ezi-5) ngokuqhelekileyo sidlulela kwikoloni, emathunjini amakhulu .
Kodwa ukuba ininzi ye-bile acids yenza indlela yawo emathunjini amakhulu, ivuselela ukufihla kwamanzi, okwenza izikhumba zidibeneyo, amanzi kunye nesifo sohudo. Le meko yaziwa ngokuba yi- bile acid malabsorption (BAM). Ukungabikho kwezifo zesifo esiswini okanye ukulimala, i-malabsorption ibonakaliswa njengohlobo lwe-BAM, okunye okubizwa ngokuba yi-idiopathic okanye i-BAM eyintloko (I-BAM okanye i-P-BAM).
I-BAM ngokuqhelekileyo icinga ukuba yinto engavumelekanga. Nangona kunjalo, uphononongo uphando lubone ukuba malunga neepesenti ezingama-25 ukuya kuma-30 ezigulane ezineempawu ze-IBS-D zivavanywe kakuhle nge-I-BAM isebenzisa i-75SeHCAT yokuhlola.
Njengengxenye yolu hlalutyo, idatha ibonise ukuba izigulane ezinikezelwe ngamachiza ejoliswe kujoliswe kwi-bile acid sequestrants ezimalunga nezinga le-malabsorption njengoko lilinganiswa yinkqubo ye-nuclear nyukliya yabonisa ukuphucula uphawu.
Abaphandi baphetha ngelithi i-I-BAM engaxilwanga ngokungazi kakuhle ngokusasazeka kwayo kunye nokungabikho kokufikelela kwi-scan (ayifumaneki e-US) inokukhokelela kwizigulane ezininzi ze-IBS-D ezingafumani unyango olufanelekileyo kunye .
Enye Imfundiso
Abaphandi baye bazama ukuqhubela phambili ukuqonda ukuba yintoni enokubangela le nkinga ye-acid acid malabsorption.
Enye into eyenzekayo yileyali (intombazana encinci), i-FGF19, enoxanduva lokulawula i-bile acid production. Kungenzeka ukuba amazinga aphantsi ale hormone abangela ukuba i-bile acids ibe yinto egqithisileyo eyenza ukuthungatha emathunjini amakhulu. Uphando luqhubeka ukuqonda kakuhle le ntsebenzo, nethemba lokuba inokukhokelela kumachiza ejolise ngqo kwingxaki.
Ngaphantsi
Njengoko kumangalisa njengoko inani lama-25 ukuya kuma-30 ekhulwini, kubalulekile ukuqaphela ukuba le ndawo yophando ibonakala iqhutyelwa liqela elithile labaphandi. Kwaye, ngelishwa, njengoko i-75SeHCAT iskripthi ayitholakali e-US, akukhona nje ukuba kukho ukuvavanywa kwegazi ngokukhawuleza ukufumanisa ukuba i-IBS-D yakho iyimi-BAM. Nangona kunjalo, ukuba uhlala ukhululekile, izithambiso zamanzi njengenxalenye yesithombe sakho somqondiso, unokufuna ukuthetha nodokotela wakho ukuba ubone ukuba ngaba ngumviwa wokuvavanywa kwamachiza asetyenziswa ukuphatha i-BAM.
Imithombo:
Pattni, S. & Walters, J. "Ukuqhubela phambili kwindlela yokuqonda i-bile acid malabsorption" I- British Medical Bulletin 2009 92: 79-93.
UWalters, J. "Ukuchaza isifo sohudo se-bindi esiliphambili: ukwenza ukuxilongwa nokuqonda ingxaki" Iingxelo zoLwazi 2010 4: 561-567.
Wedlake, L., et.al. Ukuhlaziywa ngokucwangcisiweyo: ukubaluleka kwe-idiopathic bile acid malabsorption njengoko kufunyanwe ngu-SeHCAT ukuskena kwizigulane ezine-diarrhea-ezibangelwa ngumzimba wesifo se-bowel syndrome. "I- Pharmacology kunye ne-Therapeutics 2009: 30: 707-717.
UWalters, J. "Ukuchaza isifo sohudo se-bindi esiliphambili: ukwenza ukuxilongwa nokuqonda ingxaki" Iingxelo zoLwazi 2010 4: 561-567.