UMichael J. Fox, oneminyaka engama-54, uyaziwa ngezinto ezininzi. Umdlali ophelileyo, uzuze umvuzo wakhe ngomsebenzi wakhe "kwiiNtsapho zentsapho," "iTown City" kunye ne "Umfazi Olungileyo." Nangona kunjalo, ukuphumelela kweFox - iGrammy yakhe, uEmys, kunye neGolds Awards ngaphandle kwayo-ingaba ngumsebenzi wakhe wokuphelisa isifo sikaParkinson. Umdlali wequmrhu eliseMichael J. Fox Foundation loPhando lwe-Parkinson (MJFF) ngo-2000, iminyaka engama-9 emva kokufunyaniswa nesimo.
Ukususela ekudibaniseni ukuxilongwa kwakhe kuluntu ngo-1998, uFox uthetha uphando lwe-cell stem kwaye usebenze ngokukhawuleza ukunyusa imali yophando. I-fox okwamanje isebenza njengomseli wenhlangano kwaye ihleli kwibhodi yabalawuli.
UMasipala waseMichael J. Fox woPhando lweParkinson
Uphando lukaMichael J. Fox loPhando lwe-Parkinson lunikezelwe ukufumana unyango lwesifo sika-Parkinson. Kuza kube namhlanje, isiseko sikhulise ngaphezu kwezigidi ezingama-450 kuphando lukaParkinson. I-MJFF ijolise ekuphuhliseni unyango olungcono kwiimpawu ezibhekiselele phantsi kwesifo-ezifana nokuqhawulwa, iingxaki zokugwinya, ukulawula umgudu, kunye nokuncipha kwengqondo - kunye nemiphumo echaphazelekayo yeengxaki zamachiza e-Parkinson yangoku.
Ziziphi izifo zeParkinson?
Isifo se-Parkinson sichaphazela inkqubo yesistim ehamba phambili eyenza iimpawu eziqhubekayo, eziphazamisayo eziphazamisa indlela umzimba uhamba ngayo.
Uphawu oluphawulekayo lwaloo mimoya, ngakumbi ezandleni. "I-Parkinson" yixesha eliqhelekileyo ubuncinane kwiintlobo ezahlukeneyo zesithintelo, ezininzi zazo zichaphazela abantu abangaphezu kwama-50 ubudala. Phantse isigidi esisodwa saseMerika ngoku sihlala nesifo sikaParkinson.
Phantse ama-30 ekhulwini labantu abane-Parkinson bafunyaniswa phambi kokuba abaneminyaka engama-50 ukuya kuma-20 aba bantu baxilongwa ngaphambi kokuba babe neminyaka engama-40. Xa iParkinson iqala ngaphambi kweminyaka engama-50, iyaziwa ngokuba yi-Parkinson. UMichael J. Fox, owayefunyaniswe xa sele eneminyaka engama-30 ubudala, kulolu hlobo.
Abantu abanesifo sika-Parkinson banokungabikho kwemichiza echaphazela ukunyakaza (okubizwa ngokuba yi-dopamine) kwiibhokhwe zabo. Oku kubangelwa utshintsho kwiiseli ze-substantia nigra, indawo yengqondo evelisa i-dopamine. Ezi zinguqu zenzeke ziyaziwa. Iingcamango zibandakanya ukuguga ngokukhawuleza, ukukhuselwa kwemvelo, kunye nemeko yendalo, phakathi kwabanye. Ininzi isifo sikaPasinson sibangelwa ukudibanisa kwezi zinto.
Ukufumana unyango
Ukunyangwa kwesifo sikaParkinson kuye kwakuba ngamayeza angenziwa kwi-dopamine kwingqondo (Sinemet), okanye ngeziyobisi ezibonakala zichaphazela ukusetyenziswa kwe-dopamine kwingqondo (Symmetrel, Eldepryl). Unyango lunokubandakanya i-dopamine agonists (i-Parlodel, i-Permax, i-Mirapex, i-Requip), eyenza iiseli zengqondo zengqondo ze-dopamine.
Izinketho zokwelapha zonyango ziyafumaneka. Enye yeendlela eziqhelekileyo zokugonywa ngophupho olusisiseko sengqondo (DBS).
I-DBS yaphuhliswa kuma-1990 kwaye ngoku iindlela eziqhelekileyo zokuphatha le meko. Ngoxa i-DBS inokukunceda ukunyanga iimpawu, ayiyiphilisi eso sifo kwaye ayiyi kuyenza ukuba ingaqhubeki. Iinkqubo zeThalamotomy kunye ne-pallidotomy, ezonakalisa "iindiza ezinobangela iingxaki" kwingqondo usebenzisa i-electrode, ziyafumaneka.
Imithombo
Uphando lukaMichael J. Fox loPhando lwe-Parkinson (2016)
I-Parkinson's Disease Foundation (2016)