Ukuhamba, ukulinganisela, nezakhono zamandla amaninzi ezichaphazelekayo
I-progress multiple sclerosis (PPMS) ehamba phambili ichaphazela abaninzi abantu abasibhozo abaphila nge-multiple sclerosis. Kuzo iintlobo ezahlukeneyo zesifo , i-PPMS ithathwa njengengxaki.
Indlela iPMS ihluke ngayo kwezinye iifom ze-MS
Ifomu eqhelekileyo, eyaziwa ngokuba yi -MS yokubuyisela kwakhona (RRMS) , ibonakala ngokuhlaselwa ngokukhawuleza okulandelwa ngamaxesha okukhululwa apho isifo esingaqhubekiyo.
Xa iqhuba inkqubela phambili, umntu kuthiwa unentuthuko yesibini (SPMS) .
I-PPMS, ngokuchaseneyo, iqhubela phambili ukusuka ekuqaleni. Umntu ofumene i-PPMS ayinayo iifayile eziqhelekileyo okanye aphinde abuyele kwi-RRMS okanye i-SPMS. Endaweni yoko, iimpawu zivela kancane kwaye aziphenduli.
Nje ngezinye iindlela ze-sclerosis ezininzi, ikhosi ye-PPMS iguquke kakhulu, ichaphazela umntu ngamnye. Abanye banokukhubazeka kwiminyaka embalwa kanti abanye bahlala bezinzile iminyaka emininzi.
Iimpawu ezihambelana noMgca woMgcini
Ngokuphathelele iimpawu, abantu abaxilongwa nge-PPMS baya kudla ukuhamba neengxaki ngenxa ye-atrophy yokuqhubekayo (ukuchithwa nokuguqulwa) kwintambo yomgogodla. Eyaziwa ngokuba yi-myelopathy eqhubekayo, iimpawu zingabandakanya:
- I-gait ethe xaxa ebizwa ngokuba yi-parasisis spastic, apho imilenze iya kuqala ukuqina, kubangele ukukhanya okubonakalayo kunye / okanye isantya
- Ubuthathaka okanye ukungahambi kwelinye icala lomzimba, obizwa ngokuba yi- hemiparesis ye-spastic, enokuchaphazela imilenze, iingalo, okanye izandla
- Ukunyamezela (ukunciphisa amandla okwenza umsebenzi)
- Ukuhlutha kunye nokungabikho kwemisipha yokudibanisa ( ataxia )
Xa intambo yomgudu ichaphazeleka sisifo, inokuphazamisa ngaphezu kokuhamba nje.
Ingabangela ukuphazamiseka komsebenzi wesondo, isisu, kunye nesilonda. Ukukhathala kuqhelekile nakwezinye iindidi ze-sclerosis ezininzi.
Iimpawu ezihambelana neBrain
Nangona intambo yomgudu iyona nto iphambili yokujoliswa kokulimala kwi-PPMS, ingqondo ingasichaphazeleka, ngokuyinxalenye inxalenye eyaziwa ngokuba yi- cerebellum elawula ukulinganisela nokulungelelaniswa. Eyaziwa ngokuba yi-cerebellar syndrome eqhubekayo (i-PCS), ukuphazamiseka kwesifo kuchaphazela omnye wabantu aba-10 abafumana i-PPMS kwaye banokubonakala ngoku:
- Ukuphazamiseka kokunyuka kwesandla esihle ngenxa yesondlo esinamandla
- Ukulahlekelwa kwetoni ye-muscle (hypotonia)
- Ukulahlekelwa kwe-balance (gait ataxia)
- Ukungakwazi ukulungelelanisa ukunyakaza (i-dysmetria) apho umntu engaphezu kwamanzi okanye ngaphaya kweendawo ezifunyenweyo zengalo, umlenze, okanye isandla
- Ukungakwazi ukwenza intshukumo yokutshintsha ngokukhawuleza (i- dysdiadochokinesia ) efana nokukrabhula kwibhebhu
Ukuvuvukala kunye nokuveliswa kwe-neurodegeneration kubonakala ngathi ziindlela eziphambili eziphantsi kwe-cerebellar kunye nokubandakanya intambo yomgudu kumagulane e-PPMS.
Iimpawu ezingavamile ze-PPMS
Ngexesha eliqhelekileyo eliqhelekileyo, i-PPMS inokuchaphazela ezinye iinxalenye zesistim somnyoba ophakathi kwentsholongwane yengqondo (ephakathi kweengqondo kunye nomtya womthambo) kunye ne-cerebrum (umzimba ophezulu wengqondo).
Iimpawu zibonwa kuphela ngeepesenti enye zabantu abanePMS kodwa ingaquka:
- Iingxaki ngokugwinya ( dysphagia )
- Ukuxhamla, ukuhlanza, okanye isicupunu
- Ukukhawuleza, ukunyakaza okungabonakaliyo kwamehlo ( nystagmus )
- Ukukhubazeka kombono okanye ukulahleka
- Umsebenzi onokungaqondi kakuhle , kuquka ukulahleka kweememori, ukujonga ingqalelo, ukuthetha ngomlomo okanye ukucinga
ILizwi
Kuze kube kutshanje, kwakungekho namachiza ekhoyo ukuze aphathe iPMS. Izidakamizwa zokuguqula izifo, njengeRebif kunye neCopaxone, zisebenza kakhulu ngokunciphisa ukuvuvukala ezihambelana neRRMS, kodwa zibonakalise zingasebenzi ekuphatheni uhlobo lokuchithwa kwemigudu ebonakalayo kwi-PPMS.
Ngenhlanhla, izinto zitshintshile. Ngoku sinezizazi ezibizwa ngokuba ngu- Ocrevus (ocrelizumab) ezinokukwazi ukuphathwa kwePPMS kunye nokuphindaphinda iifom zesifo. Ukuvunyelwa yi-US Food and Drug Administration (FDA) ngo-Matshi 2017, i-Ocrevus ithathwa njengenguqu enkulu yemidlalo kwaye iya kuphucula ubomi balabo abaphila nale ndlela engavamile ye-sclerosis.
> Imithombo
> Ohrbach, R .; Zhao, A .; Wang, Y. et al. "Ukuthelekiswa kwezifo ezisebenza kwi-SPMS kunye ne-PPMS kwiNgqungquthela yeziLingo zeeNkliniki zeMalticenter." I- PLoS One 2012. I-DOI 10.1371 / iphephandaba.pone.0045409.
> Ulawulo lweZiko lokuTya kunye neDrug. "I-Ocrevus (ocrelizumab) Inject." Silver Spring, eMaryn; Matshi 28, 2017.